Gynura procumbens leaf improves blood glucose level, restores fertility and libido of diabetic-induced male rats

Gynura procumbens (GP) has been widely used in traditional medicine due to its ability in treating various types of diseases. This study was carried out to determine the effects of GP on blood glucose level, fertility and libido of streptozotocin-induced male rats. A total of 42 male rats were rando...

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Main Authors:	Khaidatul Akmar Kamaruzaman, Mahanem Mat Noor
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2017
Online Access:	http://journalarticle.ukm.my/11373/ http://journalarticle.ukm.my/11373/ http://journalarticle.ukm.my/11373/1/16%20Khaidatul%20Akmar.pdf

id	ukm-11373
recordtype	eprints
spelling	ukm-113732018-02-15T05:15:12Z http://journalarticle.ukm.my/11373/ Gynura procumbens leaf improves blood glucose level, restores fertility and libido of diabetic-induced male rats Khaidatul Akmar Kamaruzaman, Mahanem Mat Noor, Gynura procumbens (GP) has been widely used in traditional medicine due to its ability in treating various types of diseases. This study was carried out to determine the effects of GP on blood glucose level, fertility and libido of streptozotocin-induced male rats. A total of 42 male rats were randomly sorted into six groups; normal, negative and positive controls and three treated groups with different dosages of GP aqueous extract (GPAE); 150, 300 and 450 mg/kg. Each group was treated via oral feeding for 14 consecutive days. The rats were sacrificed on day 15 for further analysis. Administration of GPAE significantly lowered the fasting blood glucose (FBG) level and increased the plasma testosterone level of diabetic-induced rats compared to the positive and negative control groups. There was also a significant increase in the sperm quality as well as the fertility of GPAE treated groups compared to the negative and positive control groups. Sexual behaviour analysis demonstrated that GPAE is able to facilitate the expression of sexual behaviour significantly; increased mounting frequency and reduced mounting latency. These lines of evidence suggested that GPAE can act as antihyperglycaemic, profertility and libido agents. However, its mechanism(s) remains unresolved. Penerbit Universiti Kebangsaan Malaysia 2017-09 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/11373/1/16%20Khaidatul%20Akmar.pdf Khaidatul Akmar Kamaruzaman, and Mahanem Mat Noor, (2017) Gynura procumbens leaf improves blood glucose level, restores fertility and libido of diabetic-induced male rats. Sains Malaysiana, 46 (9). pp. 1471-1477. ISSN 0126-6039 http://www.ukm.my/jsm/english_journals/vol46num9_2017/contentsVol46num9_2017.html
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Gynura procumbens (GP) has been widely used in traditional medicine due to its ability in treating various types of diseases. This study was carried out to determine the effects of GP on blood glucose level, fertility and libido of streptozotocin-induced male rats. A total of 42 male rats were randomly sorted into six groups; normal, negative and positive controls and three treated groups with different dosages of GP aqueous extract (GPAE); 150, 300 and 450 mg/kg. Each group was treated via oral feeding for 14 consecutive days. The rats were sacrificed on day 15 for further analysis. Administration of GPAE significantly lowered the fasting blood glucose (FBG) level and increased the plasma testosterone level of diabetic-induced rats compared to the positive and negative control groups. There was also a significant increase in the sperm quality as well as the fertility of GPAE treated groups compared to the negative and positive control groups. Sexual behaviour analysis demonstrated that GPAE is able to facilitate the expression of sexual behaviour significantly; increased mounting frequency and reduced mounting latency. These lines of evidence suggested that GPAE can act as antihyperglycaemic, profertility and libido agents. However, its mechanism(s) remains unresolved.
format	Article
author	Khaidatul Akmar Kamaruzaman, Mahanem Mat Noor,
spellingShingle	Khaidatul Akmar Kamaruzaman, Mahanem Mat Noor, Gynura procumbens leaf improves blood glucose level, restores fertility and libido of diabetic-induced male rats
author_facet	Khaidatul Akmar Kamaruzaman, Mahanem Mat Noor,
author_sort	Khaidatul Akmar Kamaruzaman,
title	Gynura procumbens leaf improves blood glucose level, restores fertility and libido of diabetic-induced male rats
title_short	Gynura procumbens leaf improves blood glucose level, restores fertility and libido of diabetic-induced male rats
title_full	Gynura procumbens leaf improves blood glucose level, restores fertility and libido of diabetic-induced male rats
title_fullStr	Gynura procumbens leaf improves blood glucose level, restores fertility and libido of diabetic-induced male rats
title_full_unstemmed	Gynura procumbens leaf improves blood glucose level, restores fertility and libido of diabetic-induced male rats
title_sort	gynura procumbens leaf improves blood glucose level, restores fertility and libido of diabetic-induced male rats
publisher	Penerbit Universiti Kebangsaan Malaysia
publishDate	2017
url	http://journalarticle.ukm.my/11373/ http://journalarticle.ukm.my/11373/ http://journalarticle.ukm.my/11373/1/16%20Khaidatul%20Akmar.pdf
first_indexed	2023-09-18T20:00:07Z
last_indexed	2023-09-18T20:00:07Z
_version_	1777406791855898624

Gynura procumbens leaf improves blood glucose level, restores fertility and libido of diabetic-induced male rats

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