Effect of Ficus deltoidea Aqueous Extract on Blood Glucose Level in Normal and Mild Diabetics Rats

Ficus deltoidea, which is locally known as ‘mas cotek’, has been traditionally believed to have hypoglycaemic activity. In this study, hypoglycaemic activity of aqueous extract of Ficus deltoidea in normal and mild diabetic rats (Streptozotocin induced) was evaluated. The extract was administered or...

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Main Authors:	Zainal Adam, Muhajir Hamid, Amin Ismail, Shafii Khamis
Format:	Article
Language:	English
Published:	penerbit ukm 2007
Online Access:	http://journalarticle.ukm.my/1095/ http://journalarticle.ukm.my/1095/1/jurnal75.pdf

id	ukm-1095
recordtype	eprints
spelling	ukm-10952016-12-14T06:28:48Z http://journalarticle.ukm.my/1095/ Effect of Ficus deltoidea Aqueous Extract on Blood Glucose Level in Normal and Mild Diabetics Rats Zainal Adam, Muhajir Hamid, Amin Ismail, Shafii Khamis, Ficus deltoidea, which is locally known as ‘mas cotek’, has been traditionally believed to have hypoglycaemic activity. In this study, hypoglycaemic activity of aqueous extract of Ficus deltoidea in normal and mild diabetic rats (Streptozotocin induced) was evaluated. The extract was administered orally at different doses (100,500 and 1000mg/kg) to both groups in fasting and post prandial state. The result shows that the aqueous extract of Ficus deltoidea did not have any hypoglycaemic activity in normal rats as well as in fasting mild diabetic group. In post prandial mild diabetic rats, aqueous extract of Ficus deltoidea at the dose of 1000 mg/kg show hypoglycaemic activity after 2 (p<0.01), 4 (p<0.05) and 6 (p<0.01) hours extract administration. Metformin, 500 mg/kg also shows hypoglycaemic activity after 2 (p<0.05), 4 (p<0.01) and 6 (p<0.01) hours administration. Therefore, we suggested that mechanism of action of the Ficus deltoidea aqueous extract maybe through enhancement of glucose uptake to muscle tissue and reduce hepatic gluconeogenesis. penerbit ukm 2007 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/1095/1/jurnal75.pdf Zainal Adam, and Muhajir Hamid, and Amin Ismail, and Shafii Khamis, (2007) Effect of Ficus deltoidea Aqueous Extract on Blood Glucose Level in Normal and Mild Diabetics Rats. Jurnal Sains Kesihatan Malaysia, 5 (2). pp. 9-16. ISSN 1675-8161
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Ficus deltoidea, which is locally known as ‘mas cotek’, has been traditionally believed to have hypoglycaemic activity. In this study, hypoglycaemic activity of aqueous extract of Ficus deltoidea in normal and mild diabetic rats (Streptozotocin induced) was evaluated. The extract was administered orally at different doses (100,500 and 1000mg/kg) to both groups in fasting and post prandial state. The result shows that the aqueous extract of Ficus deltoidea did not have any hypoglycaemic activity in normal rats as well as in fasting mild diabetic group. In post prandial mild diabetic rats, aqueous extract of Ficus deltoidea at the dose of 1000 mg/kg show hypoglycaemic activity after 2 (p<0.01), 4 (p<0.05) and 6 (p<0.01) hours extract administration. Metformin, 500 mg/kg also shows hypoglycaemic activity after 2 (p<0.05), 4 (p<0.01) and 6 (p<0.01) hours administration. Therefore, we suggested that mechanism of action of the Ficus deltoidea aqueous extract maybe through enhancement of glucose uptake to muscle tissue and reduce hepatic gluconeogenesis.
format	Article
author	Zainal Adam, Muhajir Hamid, Amin Ismail, Shafii Khamis,
spellingShingle	Zainal Adam, Muhajir Hamid, Amin Ismail, Shafii Khamis, Effect of Ficus deltoidea Aqueous Extract on Blood Glucose Level in Normal and Mild Diabetics Rats
author_facet	Zainal Adam, Muhajir Hamid, Amin Ismail, Shafii Khamis,
author_sort	Zainal Adam,
title	Effect of Ficus deltoidea Aqueous Extract on Blood Glucose Level in Normal and Mild Diabetics Rats
title_short	Effect of Ficus deltoidea Aqueous Extract on Blood Glucose Level in Normal and Mild Diabetics Rats
title_full	Effect of Ficus deltoidea Aqueous Extract on Blood Glucose Level in Normal and Mild Diabetics Rats
title_fullStr	Effect of Ficus deltoidea Aqueous Extract on Blood Glucose Level in Normal and Mild Diabetics Rats
title_full_unstemmed	Effect of Ficus deltoidea Aqueous Extract on Blood Glucose Level in Normal and Mild Diabetics Rats
title_sort	effect of ficus deltoidea aqueous extract on blood glucose level in normal and mild diabetics rats
publisher	penerbit ukm
publishDate	2007
url	http://journalarticle.ukm.my/1095/ http://journalarticle.ukm.my/1095/1/jurnal75.pdf
first_indexed	2023-09-18T19:32:20Z
last_indexed	2023-09-18T19:32:20Z
_version_	1777405044614758400

Effect of Ficus deltoidea Aqueous Extract on Blood Glucose Level in Normal and Mild Diabetics Rats

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