Oral administration of tocotrienol ameliorates lead-induced toxicity in the rat brain

The occurrence of severe lead (Pb) poisoning has risen in certain countries. There is increasing evidence that chronic lead exposure disturbs the prooxidant: antioxidant balance in the brain tissue and alters brain histology. The present study observed the antioxidant effect of tocotrienol-rich frac...

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Main Authors:	Noor Azliza Wani Aa, Zar, Chi Thent, Mohamad Fairuz Yahaya, Teoh, Seong Lin, Taty Anna K, Azian Abd Latiff
Format:	Article
Language:	English
Published:	Faculty of Medicine, Universiti Kebangsaan Malaysia 2016
Online Access:	http://journalarticle.ukm.my/10846/ http://journalarticle.ukm.my/10846/ http://journalarticle.ukm.my/10846/1/12_noor_et_al_pdf_11204.pdf

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recordtype	eprints
spelling	ukm-108462017-10-12T09:32:26Z http://journalarticle.ukm.my/10846/ Oral administration of tocotrienol ameliorates lead-induced toxicity in the rat brain Noor Azliza Wani Aa, Zar, Chi Thent Mohamad Fairuz Yahaya, Teoh, Seong Lin Taty Anna K, Azian Abd Latiff, The occurrence of severe lead (Pb) poisoning has risen in certain countries. There is increasing evidence that chronic lead exposure disturbs the prooxidant: antioxidant balance in the brain tissue and alters brain histology. The present study observed the antioxidant effect of tocotrienol-rich fraction (TRF) on brain tissues of the experimental rats following lead poisoning. Eighteen (n=18) male Sprague-Dawley rats, 6-weeks old, were randomly divided into control (CTRL) group and experimental groups; fed with 0.2% w/v lead acetate, as PB2 group; and fed with 0.2% w/v lead acetate and daily TRF supplementation (200 mg/kg body weight) as PB2T group. The experiment was conducted for 30 days. At the end of the study, the brain tissues were harvested and histopathological changes of the hippocampal region were observed. Biochemical findings such as brain lead, TRF and malondialdehyde (MDA) levels, and erythrocyte superoxide dismutase (SOD) activity were determined. It was observed that atypical apoptotic-like and disorganized neurons were present in the hippocampal region of the untreated PB2 group compared to PB2T group. Biochemical parameters showed a significant decrease (p < 0.05) in brain lead level in PB2T compared to PB. Even though no significant difference (p > 0.05) was obtained for MDA level, there was a significant increase (p < 0.05) in the erythrocyte SOD activity in PB2T compared to PB2 and CTRL. Supplementation with TRF improved histopathological changes in the brain tissues caused by lead exposure in drinking water by reducing lead accumulation in the brain of experimental rats. Faculty of Medicine, Universiti Kebangsaan Malaysia 2016 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/10846/1/12_noor_et_al_pdf_11204.pdf Noor Azliza Wani Aa, and Zar, Chi Thent and Mohamad Fairuz Yahaya, and Teoh, Seong Lin and Taty Anna K, and Azian Abd Latiff, (2016) Oral administration of tocotrienol ameliorates lead-induced toxicity in the rat brain. Medicine & Health, 11 (2). pp. 232-244. ISSN 1823-2140 http://www.medicineandhealthukm.com/toc/11/2
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	The occurrence of severe lead (Pb) poisoning has risen in certain countries. There is increasing evidence that chronic lead exposure disturbs the prooxidant: antioxidant balance in the brain tissue and alters brain histology. The present study observed the antioxidant effect of tocotrienol-rich fraction (TRF) on brain tissues of the experimental rats following lead poisoning. Eighteen (n=18) male Sprague-Dawley rats, 6-weeks old, were randomly divided into control (CTRL) group and experimental groups; fed with 0.2% w/v lead acetate, as PB2 group; and fed with 0.2% w/v lead acetate and daily TRF supplementation (200 mg/kg body weight) as PB2T group. The experiment was conducted for 30 days. At the end of the study, the brain tissues were harvested and histopathological changes of the hippocampal region were observed. Biochemical findings such as brain lead, TRF and malondialdehyde (MDA) levels, and erythrocyte superoxide dismutase (SOD) activity were determined. It was observed that atypical apoptotic-like and disorganized neurons were present in the hippocampal region of the untreated PB2 group compared to PB2T group. Biochemical parameters showed a significant decrease (p < 0.05) in brain lead level in PB2T compared to PB. Even though no significant difference (p > 0.05) was obtained for MDA level, there was a significant increase (p < 0.05) in the erythrocyte SOD activity in PB2T compared to PB2 and CTRL. Supplementation with TRF improved histopathological changes in the brain tissues caused by lead exposure in drinking water by reducing lead accumulation in the brain of experimental rats.
format	Article
author	Noor Azliza Wani Aa, Zar, Chi Thent Mohamad Fairuz Yahaya, Teoh, Seong Lin Taty Anna K, Azian Abd Latiff,
spellingShingle	Noor Azliza Wani Aa, Zar, Chi Thent Mohamad Fairuz Yahaya, Teoh, Seong Lin Taty Anna K, Azian Abd Latiff, Oral administration of tocotrienol ameliorates lead-induced toxicity in the rat brain
author_facet	Noor Azliza Wani Aa, Zar, Chi Thent Mohamad Fairuz Yahaya, Teoh, Seong Lin Taty Anna K, Azian Abd Latiff,
author_sort	Noor Azliza Wani Aa,
title	Oral administration of tocotrienol ameliorates lead-induced toxicity in the rat brain
title_short	Oral administration of tocotrienol ameliorates lead-induced toxicity in the rat brain
title_full	Oral administration of tocotrienol ameliorates lead-induced toxicity in the rat brain
title_fullStr	Oral administration of tocotrienol ameliorates lead-induced toxicity in the rat brain
title_full_unstemmed	Oral administration of tocotrienol ameliorates lead-induced toxicity in the rat brain
title_sort	oral administration of tocotrienol ameliorates lead-induced toxicity in the rat brain
publisher	Faculty of Medicine, Universiti Kebangsaan Malaysia
publishDate	2016
url	http://journalarticle.ukm.my/10846/ http://journalarticle.ukm.my/10846/ http://journalarticle.ukm.my/10846/1/12_noor_et_al_pdf_11204.pdf
first_indexed	2023-09-18T19:58:39Z
last_indexed	2023-09-18T19:58:39Z
_version_	1777406699529830400

Oral administration of tocotrienol ameliorates lead-induced toxicity in the rat brain

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