Development of hypertensive animal model using ovariectomised rat fed with short-term 2% cholesterol diet

Menopause, a cessation of menstrual bleeding, is directly related to serious illness confined to cardiovascular disease (CVD) such as hypertension and stroke. The oestrogen withdrawal and consumption of high cholesterol diet has a detrimental effect on cardiovascular function and metabolism in menop...

Full description

Bibliographic Details
Main Authors:	Kumeshini S, Nurshazana A, Faizah Othman, Kamsiah Jaarin, Srijit Dass, Zar, Chi Thent
Format:	Article
Language:	English
Published:	Faculty of Medicine, Universiti Kebangsaan Malaysia 2016
Online Access:	http://journalarticle.ukm.my/10840/ http://journalarticle.ukm.my/10840/ http://journalarticle.ukm.my/10840/1/6_kumeshini_et_al_pdf_15539.pdf

id	ukm-10840
recordtype	eprints
spelling	ukm-108402017-10-12T09:21:23Z http://journalarticle.ukm.my/10840/ Development of hypertensive animal model using ovariectomised rat fed with short-term 2% cholesterol diet Kumeshini S, Nurshazana A, Faizah Othman, Kamsiah Jaarin, Srijit Dass, Zar, Chi Thent Menopause, a cessation of menstrual bleeding, is directly related to serious illness confined to cardiovascular disease (CVD) such as hypertension and stroke. The oestrogen withdrawal and consumption of high cholesterol diet has a detrimental effect on cardiovascular function and metabolism in menopausal women. The present study was aimed to develop the hypertensive rat model in the ovariectomised Sprague Dawley rats fed with 2% cholesterol diet following a short term period. Eighteen Sprague-Dawley rats were randomly divided into three groups; Sham control (sham), ovariectomized control fed with normal diet (Ovx +N), ovariectomized rats fed with 2% cholesterol diet (Ovx + Cho) for four weeks. At the end of the study, the food intake and body weight were measured. The systolic, diastolic and mean blood pressure was determined. OVX+Cho showed significant increase in physiological changes such as body weight and food intake compared to Ovx+N group. The significant increase in systolic, diastolic and mean blood pressure was observed in Ovx+Cho group. Based on the above findings, it is believed that feeding cholesterol diet for four weeks (short term) results in significant increase in the blood pressure, food intake and body weight in the ovariectomised rats. Faculty of Medicine, Universiti Kebangsaan Malaysia 2016 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/10840/1/6_kumeshini_et_al_pdf_15539.pdf Kumeshini S, and Nurshazana A, and Faizah Othman, and Kamsiah Jaarin, and Srijit Dass, and Zar, Chi Thent (2016) Development of hypertensive animal model using ovariectomised rat fed with short-term 2% cholesterol diet. Medicine & Health, 11 (2). pp. 171-180. ISSN 1823-2140 http://www.medicineandhealthukm.com/toc/11/2
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Menopause, a cessation of menstrual bleeding, is directly related to serious illness confined to cardiovascular disease (CVD) such as hypertension and stroke. The oestrogen withdrawal and consumption of high cholesterol diet has a detrimental effect on cardiovascular function and metabolism in menopausal women. The present study was aimed to develop the hypertensive rat model in the ovariectomised Sprague Dawley rats fed with 2% cholesterol diet following a short term period. Eighteen Sprague-Dawley rats were randomly divided into three groups; Sham control (sham), ovariectomized control fed with normal diet (Ovx +N), ovariectomized rats fed with 2% cholesterol diet (Ovx + Cho) for four weeks. At the end of the study, the food intake and body weight were measured. The systolic, diastolic and mean blood pressure was determined. OVX+Cho showed significant increase in physiological changes such as body weight and food intake compared to Ovx+N group. The significant increase in systolic, diastolic and mean blood pressure was observed in Ovx+Cho group. Based on the above findings, it is believed that feeding cholesterol diet for four weeks (short term) results in significant increase in the blood pressure, food intake and body weight in the ovariectomised rats.
format	Article
author	Kumeshini S, Nurshazana A, Faizah Othman, Kamsiah Jaarin, Srijit Dass, Zar, Chi Thent
spellingShingle	Kumeshini S, Nurshazana A, Faizah Othman, Kamsiah Jaarin, Srijit Dass, Zar, Chi Thent Development of hypertensive animal model using ovariectomised rat fed with short-term 2% cholesterol diet
author_facet	Kumeshini S, Nurshazana A, Faizah Othman, Kamsiah Jaarin, Srijit Dass, Zar, Chi Thent
author_sort	Kumeshini S,
title	Development of hypertensive animal model using ovariectomised rat fed with short-term 2% cholesterol diet
title_short	Development of hypertensive animal model using ovariectomised rat fed with short-term 2% cholesterol diet
title_full	Development of hypertensive animal model using ovariectomised rat fed with short-term 2% cholesterol diet
title_fullStr	Development of hypertensive animal model using ovariectomised rat fed with short-term 2% cholesterol diet
title_full_unstemmed	Development of hypertensive animal model using ovariectomised rat fed with short-term 2% cholesterol diet
title_sort	development of hypertensive animal model using ovariectomised rat fed with short-term 2% cholesterol diet
publisher	Faculty of Medicine, Universiti Kebangsaan Malaysia
publishDate	2016
url	http://journalarticle.ukm.my/10840/ http://journalarticle.ukm.my/10840/ http://journalarticle.ukm.my/10840/1/6_kumeshini_et_al_pdf_15539.pdf
first_indexed	2023-09-18T19:58:38Z
last_indexed	2023-09-18T19:58:38Z
_version_	1777406698639589376

Development of hypertensive animal model using ovariectomised rat fed with short-term 2% cholesterol diet

Similar Items