Memory enhancement in rats by soybean and tempeh extracts is associated with improved cholinergic and reduced neuroinflammatory activities

The continued progression of neurodegeneration may result in dementia. The present study compared the neuroprotective activities between soybean and tempeh extracts in rats. The extracts were administered orally at 10, 20 and 40 mg/kg for 15 days. Radial arm maze and elevated plus maze served as ext...

Full description

Bibliographic Details
Main Authors:	Alia Hamad, Vasudevan Mani, Kalavathy Ramasamy, Lim, Siong Meng, Abu Bakar Abdul Majeed
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2016
Online Access:	http://journalarticle.ukm.my/10271/ http://journalarticle.ukm.my/10271/ http://journalarticle.ukm.my/10271/1/02%20Alia%20Hamad.pdf

id	ukm-10271
recordtype	eprints
spelling	ukm-102712017-04-06T06:43:35Z http://journalarticle.ukm.my/10271/ Memory enhancement in rats by soybean and tempeh extracts is associated with improved cholinergic and reduced neuroinflammatory activities Alia Hamad, Vasudevan Mani, Kalavathy Ramasamy, Lim, Siong Meng Abu Bakar Abdul Majeed, The continued progression of neurodegeneration may result in dementia. The present study compared the neuroprotective activities between soybean and tempeh extracts in rats. The extracts were administered orally at 10, 20 and 40 mg/kg for 15 days. Radial arm maze and elevated plus maze served as exteroceptive behavioural models for memory measuring. Brain cholinergic activities (acetylcholine and acetylcholinesterase) and neuroinflammatory related cytokines interleukin 1β and interleukin-10 were also tested. Soybean and tempeh extracts significantly improved memory, but overall 40 mg/kg tempeh showed better improvement (p<0.05). The tempeh extracts at 20 and 40 mg/kg exhibited a significant (p<0.05) increase and decrease in the level of acetylcholine and acetylcholinesterase activities, respectively. Tempeh extract (40 mg/kg) resulted in greater reduction (p<0.05) of inflammation than soybean extract. Altogether, tempeh extract may be beneficial in the management and prevention of dementia and Alzheimer’s disease. Penerbit Universiti Kebangsaan Malaysia 2016-09 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/10271/1/02%20Alia%20Hamad.pdf Alia Hamad, and Vasudevan Mani, and Kalavathy Ramasamy, and Lim, Siong Meng and Abu Bakar Abdul Majeed, (2016) Memory enhancement in rats by soybean and tempeh extracts is associated with improved cholinergic and reduced neuroinflammatory activities. Sains Malaysiana, 45 (9). pp. 1299-1310. ISSN 0126-6039 http://www.ukm.my/jsm/english_journals/vol45num9_2016/contentsVol45num9_2016.htm
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	The continued progression of neurodegeneration may result in dementia. The present study compared the neuroprotective activities between soybean and tempeh extracts in rats. The extracts were administered orally at 10, 20 and 40 mg/kg for 15 days. Radial arm maze and elevated plus maze served as exteroceptive behavioural models for memory measuring. Brain cholinergic activities (acetylcholine and acetylcholinesterase) and neuroinflammatory related cytokines interleukin 1β and interleukin-10 were also tested. Soybean and tempeh extracts significantly improved memory, but overall 40 mg/kg tempeh showed better improvement (p<0.05). The tempeh extracts at 20 and 40 mg/kg exhibited a significant (p<0.05) increase and decrease in the level of acetylcholine and acetylcholinesterase activities, respectively. Tempeh extract (40 mg/kg) resulted in greater reduction (p<0.05) of inflammation than soybean extract. Altogether, tempeh extract may be beneficial in the management and prevention of dementia and Alzheimer’s disease.
format	Article
author	Alia Hamad, Vasudevan Mani, Kalavathy Ramasamy, Lim, Siong Meng Abu Bakar Abdul Majeed,
spellingShingle	Alia Hamad, Vasudevan Mani, Kalavathy Ramasamy, Lim, Siong Meng Abu Bakar Abdul Majeed, Memory enhancement in rats by soybean and tempeh extracts is associated with improved cholinergic and reduced neuroinflammatory activities
author_facet	Alia Hamad, Vasudevan Mani, Kalavathy Ramasamy, Lim, Siong Meng Abu Bakar Abdul Majeed,
author_sort	Alia Hamad,
title	Memory enhancement in rats by soybean and tempeh extracts is associated with improved cholinergic and reduced neuroinflammatory activities
title_short	Memory enhancement in rats by soybean and tempeh extracts is associated with improved cholinergic and reduced neuroinflammatory activities
title_full	Memory enhancement in rats by soybean and tempeh extracts is associated with improved cholinergic and reduced neuroinflammatory activities
title_fullStr	Memory enhancement in rats by soybean and tempeh extracts is associated with improved cholinergic and reduced neuroinflammatory activities
title_full_unstemmed	Memory enhancement in rats by soybean and tempeh extracts is associated with improved cholinergic and reduced neuroinflammatory activities
title_sort	memory enhancement in rats by soybean and tempeh extracts is associated with improved cholinergic and reduced neuroinflammatory activities
publisher	Penerbit Universiti Kebangsaan Malaysia
publishDate	2016
url	http://journalarticle.ukm.my/10271/ http://journalarticle.ukm.my/10271/ http://journalarticle.ukm.my/10271/1/02%20Alia%20Hamad.pdf
first_indexed	2023-09-18T19:56:55Z
last_indexed	2023-09-18T19:56:55Z
_version_	1777406591322030080

Memory enhancement in rats by soybean and tempeh extracts is associated with improved cholinergic and reduced neuroinflammatory activities

Similar Items