Fabrication and characterization of flame retardant 4 and polydimethylsiloxane as substrates for a label-free DNA sensor / Irni Hamiza Hamzah, Emilia Noorsal, Mohammad Nizam Ibrahim, Asrulnizam Abd Manaf and Othman Sidek

Fabrication and characterization of flame retardant 4 and polydimethylsiloxane as substrates for a label-free DNA sensor / Irni Hamiza Hamzah, Emilia Noorsal, Mohammad Nizam Ibrahim, Asrulnizam Abd Manaf and Othman Sidek

Silicon, glass, and ceramic are commonly used base substrates for gold (Au) deposition on label-free DNA biosensors. This study aimed to investigate the suitability of applying flame retardant 4 (FR4) as a base substrate and polydimethylsiloxane (PDMS) as a coating substrate. A thermal evaporator wa...

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Main Authors: Noorsal, Emilia, Ibrahim, Mohammad Nizam, Abd Manaf, Asrulnizam
Format: Article
Language:English
Published: Universiti Teknologi MARA, Pulau Pinang & Pusat Penerbitan Universiti (UPENA) 2013
Subjects:
TK Electrical engineering. Electronics. Nuclear engineering
Online Access:http://ir.uitm.edu.my/id/eprint/8898/
http://ir.uitm.edu.my/id/eprint/8898/1/AJ_IRNI%20HAMIZA%20HAMZAH%20EAJ%2013.pdf
id uitm-8898
recordtype eprints
spelling uitm-88982019-03-18T07:20:53Z http://ir.uitm.edu.my/id/eprint/8898/ Fabrication and characterization of flame retardant 4 and polydimethylsiloxane as substrates for a label-free DNA sensor / Irni Hamiza Hamzah, Emilia Noorsal, Mohammad Nizam Ibrahim, Asrulnizam Abd Manaf and Othman Sidek Noorsal, Emilia Ibrahim, Mohammad Nizam Abd Manaf, Asrulnizam TK Electrical engineering. Electronics. Nuclear engineering Silicon, glass, and ceramic are commonly used base substrates for gold (Au) deposition on label-free DNA biosensors. This study aimed to investigate the suitability of applying flame retardant 4 (FR4) as a base substrate and polydimethylsiloxane (PDMS) as a coating substrate. A thermal evaporator was used to fabricate copper/nickel/Au metals and ensure even deposition of Au throughout FR4. UV exposure soft lithography and wet etching were applied to develop a three-electrode pattern on the metals fabricated on FR4. A simple and straightforward technique on PDMS–FR4 bonding was proved to work at the shear strength of 55 kPa. A cyclic voltammetry (CV) method was performed using the fabricated FR4 sensor to analyze bare Au, DNA immobilization and hybridization. The FR4-based Au fabricated with PDMS acted as a coating layer between terminals and sensing electrodes, and can thus be used as a label-free DNA sensor. Universiti Teknologi MARA, Pulau Pinang & Pusat Penerbitan Universiti (UPENA) 2013 Article NonPeerReviewed text en http://ir.uitm.edu.my/id/eprint/8898/1/AJ_IRNI%20HAMIZA%20HAMZAH%20EAJ%2013.pdf Noorsal, Emilia and Ibrahim, Mohammad Nizam and Abd Manaf, Asrulnizam (2013) Fabrication and characterization of flame retardant 4 and polydimethylsiloxane as substrates for a label-free DNA sensor / Irni Hamiza Hamzah, Emilia Noorsal, Mohammad Nizam Ibrahim, Asrulnizam Abd Manaf and Othman Sidek. Esteem Academic Journal, 9 (1). pp. 1-11. ISSN 1675-7939
repository_type Digital Repository
institution_category Local University
institution Universiti Teknologi MARA
building UiTM Institutional Repository
collection Online Access
language English
topic TK Electrical engineering. Electronics. Nuclear engineering
spellingShingle TK Electrical engineering. Electronics. Nuclear engineering
Noorsal, Emilia
Ibrahim, Mohammad Nizam
Abd Manaf, Asrulnizam
Fabrication and characterization of flame retardant 4 and polydimethylsiloxane as substrates for a label-free DNA sensor / Irni Hamiza Hamzah, Emilia Noorsal, Mohammad Nizam Ibrahim, Asrulnizam Abd Manaf and Othman Sidek
description Silicon, glass, and ceramic are commonly used base substrates for gold (Au) deposition on label-free DNA biosensors. This study aimed to investigate the suitability of applying flame retardant 4 (FR4) as a base substrate and polydimethylsiloxane (PDMS) as a coating substrate. A thermal evaporator was used to fabricate copper/nickel/Au metals and ensure even deposition of Au throughout FR4. UV exposure soft lithography and wet etching were applied to develop a three-electrode pattern on the metals fabricated on FR4. A simple and straightforward technique on PDMS–FR4 bonding was proved to work at the shear strength of 55 kPa. A cyclic voltammetry (CV) method was performed using the fabricated FR4 sensor to analyze bare Au, DNA immobilization and hybridization. The FR4-based Au fabricated with PDMS acted as a coating layer between terminals and sensing electrodes, and can thus be used as a label-free DNA sensor.
format Article
author Noorsal, Emilia
Ibrahim, Mohammad Nizam
Abd Manaf, Asrulnizam
author_facet Noorsal, Emilia
Ibrahim, Mohammad Nizam
Abd Manaf, Asrulnizam
author_sort Noorsal, Emilia
title Fabrication and characterization of flame retardant 4 and polydimethylsiloxane as substrates for a label-free DNA sensor / Irni Hamiza Hamzah, Emilia Noorsal, Mohammad Nizam Ibrahim, Asrulnizam Abd Manaf and Othman Sidek
title_short Fabrication and characterization of flame retardant 4 and polydimethylsiloxane as substrates for a label-free DNA sensor / Irni Hamiza Hamzah, Emilia Noorsal, Mohammad Nizam Ibrahim, Asrulnizam Abd Manaf and Othman Sidek
title_full Fabrication and characterization of flame retardant 4 and polydimethylsiloxane as substrates for a label-free DNA sensor / Irni Hamiza Hamzah, Emilia Noorsal, Mohammad Nizam Ibrahim, Asrulnizam Abd Manaf and Othman Sidek
title_fullStr Fabrication and characterization of flame retardant 4 and polydimethylsiloxane as substrates for a label-free DNA sensor / Irni Hamiza Hamzah, Emilia Noorsal, Mohammad Nizam Ibrahim, Asrulnizam Abd Manaf and Othman Sidek
title_full_unstemmed Fabrication and characterization of flame retardant 4 and polydimethylsiloxane as substrates for a label-free DNA sensor / Irni Hamiza Hamzah, Emilia Noorsal, Mohammad Nizam Ibrahim, Asrulnizam Abd Manaf and Othman Sidek
title_sort fabrication and characterization of flame retardant 4 and polydimethylsiloxane as substrates for a label-free dna sensor / irni hamiza hamzah, emilia noorsal, mohammad nizam ibrahim, asrulnizam abd manaf and othman sidek
publisher Universiti Teknologi MARA, Pulau Pinang & Pusat Penerbitan Universiti (UPENA)
publishDate 2013
url http://ir.uitm.edu.my/id/eprint/8898/
http://ir.uitm.edu.my/id/eprint/8898/1/AJ_IRNI%20HAMIZA%20HAMZAH%20EAJ%2013.pdf
first_indexed 2023-09-18T22:47:35Z
last_indexed 2023-09-18T22:47:35Z
_version_ 1777417327900360704

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