Vanadium complexes of hydroxamic acids: Synthesis, characterisation and cytotoxicity investigation / Amalina Mohd Tajuddin

Vanadium complexes of hydroxamic acids: Synthesis, characterisation and cytotoxicity investigation / Amalina Mohd Tajuddin

Two hydroxamic acid ligands, benzohydroxamic acid (BHA) and salicylhydroxamic acid (SHA) which are commercially available are reacted with vanadyl sulphate to obtain new hydroxamic acid complexes, [VO(BHA)2(H2O)] and [VO(SHA)2(H2O)]. The ratio of benzohydroxamic acid and salicylhydroxamic acid with...

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Main Author: Amalina, Mohd Tajuddin
Format: Student Project
Language:English
Published: Faculty of Applied Sciences 2009
Subjects:
Salts
Online Access:http://ir.uitm.edu.my/id/eprint/745/
http://ir.uitm.edu.my/id/eprint/745/1/PPb_AMALINA%20MOHD%20TAJUDDIN%20AS%2009_5.pdf
id uitm-745
recordtype eprints
spelling uitm-7452017-04-19T08:13:56Z http://ir.uitm.edu.my/id/eprint/745/ Vanadium complexes of hydroxamic acids: Synthesis, characterisation and cytotoxicity investigation / Amalina Mohd Tajuddin Amalina, Mohd Tajuddin Salts Two hydroxamic acid ligands, benzohydroxamic acid (BHA) and salicylhydroxamic acid (SHA) which are commercially available are reacted with vanadyl sulphate to obtain new hydroxamic acid complexes, [VO(BHA)2(H2O)] and [VO(SHA)2(H2O)]. The ratio of benzohydroxamic acid and salicylhydroxamic acid with vanadyl sulphate is 2:1 (BHA:VOSO4 and SHA:VOSO4). The hydroxamic acid ligands and complexes are characterised by various techniques which are elemental analysis, IR spectroscopy, 1H NMR, magnetic susceptibility measurements and melting point determination. The results suggest that the hydroxamic acid ligands coordinate to the metal ion as singly deprotonated hydroxamato via the oxygen of the carbonyl group and hydroxyl group in bidentate manner and one molecule of water. The cytotoxicity of the ligands and their vanadyl complexes are evaluated in-vitro using Chang liver cell culture. The ligands and [VO(SHA)2(H2O)] are found to be non-toxic whereas [VO(BHA)2(H2O)] is very mildly toxic with the lowest cell viability of 54.9% at 100 μM after 72 h of exposure Faculty of Applied Sciences 2009 Student Project NonPeerReviewed text en http://ir.uitm.edu.my/id/eprint/745/1/PPb_AMALINA%20MOHD%20TAJUDDIN%20AS%2009_5.pdf Amalina, Mohd Tajuddin (2009) Vanadium complexes of hydroxamic acids: Synthesis, characterisation and cytotoxicity investigation / Amalina Mohd Tajuddin. [Student Project] (Unpublished)
repository_type Digital Repository
institution_category Local University
institution Universiti Teknologi MARA
building UiTM Institutional Repository
collection Online Access
language English
topic Salts
spellingShingle Salts
Amalina, Mohd Tajuddin
Vanadium complexes of hydroxamic acids: Synthesis, characterisation and cytotoxicity investigation / Amalina Mohd Tajuddin
description Two hydroxamic acid ligands, benzohydroxamic acid (BHA) and salicylhydroxamic acid (SHA) which are commercially available are reacted with vanadyl sulphate to obtain new hydroxamic acid complexes, [VO(BHA)2(H2O)] and [VO(SHA)2(H2O)]. The ratio of benzohydroxamic acid and salicylhydroxamic acid with vanadyl sulphate is 2:1 (BHA:VOSO4 and SHA:VOSO4). The hydroxamic acid ligands and complexes are characterised by various techniques which are elemental analysis, IR spectroscopy, 1H NMR, magnetic susceptibility measurements and melting point determination. The results suggest that the hydroxamic acid ligands coordinate to the metal ion as singly deprotonated hydroxamato via the oxygen of the carbonyl group and hydroxyl group in bidentate manner and one molecule of water. The cytotoxicity of the ligands and their vanadyl complexes are evaluated in-vitro using Chang liver cell culture. The ligands and [VO(SHA)2(H2O)] are found to be non-toxic whereas [VO(BHA)2(H2O)] is very mildly toxic with the lowest cell viability of 54.9% at 100 μM after 72 h of exposure
format Student Project
author Amalina, Mohd Tajuddin
author_facet Amalina, Mohd Tajuddin
author_sort Amalina, Mohd Tajuddin
title Vanadium complexes of hydroxamic acids: Synthesis, characterisation and cytotoxicity investigation / Amalina Mohd Tajuddin
title_short Vanadium complexes of hydroxamic acids: Synthesis, characterisation and cytotoxicity investigation / Amalina Mohd Tajuddin
title_full Vanadium complexes of hydroxamic acids: Synthesis, characterisation and cytotoxicity investigation / Amalina Mohd Tajuddin
title_fullStr Vanadium complexes of hydroxamic acids: Synthesis, characterisation and cytotoxicity investigation / Amalina Mohd Tajuddin
title_full_unstemmed Vanadium complexes of hydroxamic acids: Synthesis, characterisation and cytotoxicity investigation / Amalina Mohd Tajuddin
title_sort vanadium complexes of hydroxamic acids: synthesis, characterisation and cytotoxicity investigation / amalina mohd tajuddin
publisher Faculty of Applied Sciences
publishDate 2009
url http://ir.uitm.edu.my/id/eprint/745/
http://ir.uitm.edu.my/id/eprint/745/1/PPb_AMALINA%20MOHD%20TAJUDDIN%20AS%2009_5.pdf
first_indexed 2023-09-18T22:44:58Z
last_indexed 2023-09-18T22:44:58Z
_version_ 1777417163525586944

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