pH-sensitive nanoparticles as carriers for oral delivery of a model peptidomimetic drug / Rosa Elizabeth Valente Pereira
Peptide-related drugs are usually unstable in the harsh gastrointestinal environment with poor absorption throughout the gut. The potential of anionic pH-sensitive nanoparticles to act as novel drug carriers for oral administration of such compounds was investigated using a peptidomimetic drug, cefo...
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2008
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Online Access: | http://ir.uitm.edu.my/id/eprint/5480/ http://ir.uitm.edu.my/id/eprint/5480/1/TP_ROSA%20ELIZABETH%20VALENTE%20PEREIRA%20PH%2008_5%201.pdf |
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uitm-54802016-11-26T06:51:00Z http://ir.uitm.edu.my/id/eprint/5480/ pH-sensitive nanoparticles as carriers for oral delivery of a model peptidomimetic drug / Rosa Elizabeth Valente Pereira Valente Pereira, Rosa Elizabeth Drugs and their actions Pharmaceutical dosage forms Nanoparticles Peptide-related drugs are usually unstable in the harsh gastrointestinal environment with poor absorption throughout the gut. The potential of anionic pH-sensitive nanoparticles to act as novel drug carriers for oral administration of such compounds was investigated using a peptidomimetic drug, cefotaxime sodium. Drug loaded nanoparticles were prepared using a pH-controlled nanoprecipitation method. Three types of nanoparticles were prepared using different grades of Eudragit polymer, namely L100, L100-55 and S100. The drug-loaded nanoparticles have a size of about 100 nm, low polydispersity, encapsulation efficiencies of more than 50%, drug entrapment and drug content between 4-5%. 2008 Thesis NonPeerReviewed text en http://ir.uitm.edu.my/id/eprint/5480/1/TP_ROSA%20ELIZABETH%20VALENTE%20PEREIRA%20PH%2008_5%201.pdf Valente Pereira, Rosa Elizabeth (2008) pH-sensitive nanoparticles as carriers for oral delivery of a model peptidomimetic drug / Rosa Elizabeth Valente Pereira. PhD thesis, Universiti Teknologi MARA. |
repository_type |
Digital Repository |
institution_category |
Local University |
institution |
Universiti Teknologi MARA |
building |
UiTM Institutional Repository |
collection |
Online Access |
language |
English |
topic |
Drugs and their actions Pharmaceutical dosage forms Nanoparticles |
spellingShingle |
Drugs and their actions Pharmaceutical dosage forms Nanoparticles Valente Pereira, Rosa Elizabeth pH-sensitive nanoparticles as carriers for oral delivery of a model peptidomimetic drug / Rosa Elizabeth Valente Pereira |
description |
Peptide-related drugs are usually unstable in the harsh gastrointestinal environment with poor absorption throughout the gut. The potential of anionic pH-sensitive nanoparticles to act as novel drug carriers for oral administration of such compounds was investigated using a peptidomimetic drug, cefotaxime sodium. Drug loaded nanoparticles were prepared using a pH-controlled nanoprecipitation method. Three types of nanoparticles were prepared using different grades of Eudragit polymer, namely L100, L100-55 and S100. The drug-loaded nanoparticles have a size of about 100 nm, low polydispersity, encapsulation efficiencies of more than 50%, drug entrapment and drug content between 4-5%. |
format |
Thesis |
author |
Valente Pereira, Rosa Elizabeth |
author_facet |
Valente Pereira, Rosa Elizabeth |
author_sort |
Valente Pereira, Rosa Elizabeth |
title |
pH-sensitive nanoparticles as carriers for oral delivery of a model peptidomimetic drug / Rosa Elizabeth Valente Pereira |
title_short |
pH-sensitive nanoparticles as carriers for oral delivery of a model peptidomimetic drug / Rosa Elizabeth Valente Pereira |
title_full |
pH-sensitive nanoparticles as carriers for oral delivery of a model peptidomimetic drug / Rosa Elizabeth Valente Pereira |
title_fullStr |
pH-sensitive nanoparticles as carriers for oral delivery of a model peptidomimetic drug / Rosa Elizabeth Valente Pereira |
title_full_unstemmed |
pH-sensitive nanoparticles as carriers for oral delivery of a model peptidomimetic drug / Rosa Elizabeth Valente Pereira |
title_sort |
ph-sensitive nanoparticles as carriers for oral delivery of a model peptidomimetic drug / rosa elizabeth valente pereira |
publishDate |
2008 |
url |
http://ir.uitm.edu.my/id/eprint/5480/ http://ir.uitm.edu.my/id/eprint/5480/1/TP_ROSA%20ELIZABETH%20VALENTE%20PEREIRA%20PH%2008_5%201.pdf |
first_indexed |
2023-09-18T22:47:07Z |
last_indexed |
2023-09-18T22:47:07Z |
_version_ |
1777417299151552512 |