pH-sensitive nanoparticles as carriers for oral delivery of a model peptidomimetic drug / Rosa Elizabeth Valente Pereira
Peptide-related drugs are usually unstable in the harsh gastrointestinal environment with poor absorption throughout the gut. The potential of anionic pH-sensitive nanoparticles to act as novel drug carriers for oral administration of such compounds was investigated using a peptidomimetic drug, cefo...
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| Format: | Thesis |
| Language: | English |
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2008
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| Online Access: | http://ir.uitm.edu.my/id/eprint/5480/ http://ir.uitm.edu.my/id/eprint/5480/1/TP_ROSA%20ELIZABETH%20VALENTE%20PEREIRA%20PH%2008_5%201.pdf |
| Summary: | Peptide-related drugs are usually unstable in the harsh gastrointestinal environment with poor absorption throughout the gut. The potential of anionic pH-sensitive nanoparticles to act as novel drug carriers for oral administration of such compounds was investigated using a peptidomimetic drug, cefotaxime sodium. Drug loaded nanoparticles were prepared using a pH-controlled nanoprecipitation method. Three types of nanoparticles were prepared using different grades of Eudragit polymer, namely L100, L100-55 and S100. The drug-loaded nanoparticles have a size of about 100 nm, low polydispersity, encapsulation efficiencies of more than 50%, drug entrapment and drug content between 4-5%. |
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