Effect on paternal supplementation of palm oil (Tocotrienol Rich Fraction) on male fertility / Noor Arshikin Talib

Tocotrienol Rich fraction (TRF) is composed of tocotrienol isomer that is part of Vitamin E family. This study was performed to investigate the fertility potential and toxicity effects of TRF on male rats. Fifteen (15) adult male Wistar rats were randomly divided into 5 groups (n=3). Control negativ...

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Main Author:	Talib, Noor Arshikin
Format:	Thesis
Language:	English
Published:	2015
Subjects:	Genetics Reproduction
Online Access:	http://ir.uitm.edu.my/id/eprint/28019/ http://ir.uitm.edu.my/id/eprint/28019/1/TD_NOOR%20ARSHIKIN%20TALIB%20HS%2015_5.pdf

id	uitm-28019
recordtype	eprints
spelling	uitm-280192020-02-07T01:33:21Z http://ir.uitm.edu.my/id/eprint/28019/ Effect on paternal supplementation of palm oil (Tocotrienol Rich Fraction) on male fertility / Noor Arshikin Talib Talib, Noor Arshikin Genetics Reproduction Tocotrienol Rich fraction (TRF) is composed of tocotrienol isomer that is part of Vitamin E family. This study was performed to investigate the fertility potential and toxicity effects of TRF on male rats. Fifteen (15) adult male Wistar rats were randomly divided into 5 groups (n=3). Control negative groups was administered orally with distilled water (F), control positive group (G) groups were administered orally with tocopherol stripped com oil and TRF supplementation at dose of 30 mg/kg (H), 60 mg/kg(I) and 90 mg/kg(J). After 7 days of treatment, blood collection was performed by retro orbital sinus for biochemical analysis while sperm were collected from cauda epididymis for sperm analysis. 60 mg/kg showed the highest level of sperm count among TRF treatment group even though the positive control showed the highest sperm count among all groups. The results also showed normal sperm morphology were significantly increased in treated group (H-J) compared to negative/positive group. Hepatotoxicity assessment revealed significant decreased in ALP group in 30 mg/kg and 60 mg/kg of TRF treated group with control groups but no significant difference in AST, and ALT were found. Renal profile for nephrotoxicity of creatinine and urea level also showed no significant different. Reproductive hormone profile of FSH and LH showed significant difference however testosterone showed no significant different. Nevertheless, histological finding has revealed the improvement of spermatogenesis activity in 30 mg/kg and 60 mg/kg of TRF. This study was suggested that TRF have potential in improving fertility without significant hepatotoxicity and nephrotoxicity effect 2015 Thesis NonPeerReviewed text en http://ir.uitm.edu.my/id/eprint/28019/1/TD_NOOR%20ARSHIKIN%20TALIB%20HS%2015_5.pdf Talib, Noor Arshikin (2015) Effect on paternal supplementation of palm oil (Tocotrienol Rich Fraction) on male fertility / Noor Arshikin Talib. Degree thesis, Universiti Teknologi MARA.
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Teknologi MARA
building	UiTM Institutional Repository
collection	Online Access
language	English
topic	Genetics Reproduction
spellingShingle	Genetics Reproduction Talib, Noor Arshikin Effect on paternal supplementation of palm oil (Tocotrienol Rich Fraction) on male fertility / Noor Arshikin Talib
description	Tocotrienol Rich fraction (TRF) is composed of tocotrienol isomer that is part of Vitamin E family. This study was performed to investigate the fertility potential and toxicity effects of TRF on male rats. Fifteen (15) adult male Wistar rats were randomly divided into 5 groups (n=3). Control negative groups was administered orally with distilled water (F), control positive group (G) groups were administered orally with tocopherol stripped com oil and TRF supplementation at dose of 30 mg/kg (H), 60 mg/kg(I) and 90 mg/kg(J). After 7 days of treatment, blood collection was performed by retro orbital sinus for biochemical analysis while sperm were collected from cauda epididymis for sperm analysis. 60 mg/kg showed the highest level of sperm count among TRF treatment group even though the positive control showed the highest sperm count among all groups. The results also showed normal sperm morphology were significantly increased in treated group (H-J) compared to negative/positive group. Hepatotoxicity assessment revealed significant decreased in ALP group in 30 mg/kg and 60 mg/kg of TRF treated group with control groups but no significant difference in AST, and ALT were found. Renal profile for nephrotoxicity of creatinine and urea level also showed no significant different. Reproductive hormone profile of FSH and LH showed significant difference however testosterone showed no significant different. Nevertheless, histological finding has revealed the improvement of spermatogenesis activity in 30 mg/kg and 60 mg/kg of TRF. This study was suggested that TRF have potential in improving fertility without significant hepatotoxicity and nephrotoxicity effect
format	Thesis
author	Talib, Noor Arshikin
author_facet	Talib, Noor Arshikin
author_sort	Talib, Noor Arshikin
title	Effect on paternal supplementation of palm oil (Tocotrienol Rich Fraction) on male fertility / Noor Arshikin Talib
title_short	Effect on paternal supplementation of palm oil (Tocotrienol Rich Fraction) on male fertility / Noor Arshikin Talib
title_full	Effect on paternal supplementation of palm oil (Tocotrienol Rich Fraction) on male fertility / Noor Arshikin Talib
title_fullStr	Effect on paternal supplementation of palm oil (Tocotrienol Rich Fraction) on male fertility / Noor Arshikin Talib
title_full_unstemmed	Effect on paternal supplementation of palm oil (Tocotrienol Rich Fraction) on male fertility / Noor Arshikin Talib
title_sort	effect on paternal supplementation of palm oil (tocotrienol rich fraction) on male fertility / noor arshikin talib
publishDate	2015
url	http://ir.uitm.edu.my/id/eprint/28019/ http://ir.uitm.edu.my/id/eprint/28019/1/TD_NOOR%20ARSHIKIN%20TALIB%20HS%2015_5.pdf
first_indexed	2023-09-18T23:19:26Z
last_indexed	2023-09-18T23:19:26Z
_version_	1777419331685056512

Effect on paternal supplementation of palm oil (Tocotrienol Rich Fraction) on male fertility / Noor Arshikin Talib

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