Design of controlled-release chitosan spheroids prepared by extrusion-spheronization technique using microwave / Zabliza Zakaria

The interplay effects of matrix formulations with microwave on drug release were investigated using an agglomerate system. Chitosan spheroids were formulated with stearic acid and/or sodium chloride by extrusion-spheronization technique, and chlorpheniramine maleate as water-soluble model drug. The...

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Main Author:	Zakaria, Zabliza
Format:	Thesis
Language:	English
Published:	2010
Subjects:	Materia medica
Online Access:	http://ir.uitm.edu.my/id/eprint/27661/ http://ir.uitm.edu.my/id/eprint/27661/1/TM_ZABLIZA%20ZAKARIA%20PH%2010_5.pdf

id	uitm-27661
recordtype	eprints
spelling	uitm-276612020-01-23T09:01:47Z http://ir.uitm.edu.my/id/eprint/27661/ Design of controlled-release chitosan spheroids prepared by extrusion-spheronization technique using microwave / Zabliza Zakaria Zakaria, Zabliza Materia medica The interplay effects of matrix formulations with microwave on drug release were investigated using an agglomerate system. Chitosan spheroids were formulated with stearic acid and/or sodium chloride by extrusion-spheronization technique, and chlorpheniramine maleate as water-soluble model drug. The spheroids were treated by microwave at 80 W for 5 to 40 min. The profiles of drug dissolution, drug content, drug-polymer interaction, polymer-polymer interaction, sodium leaching, matrix morphology and integrity were determined. Unlike chitosan matrix prepared by ionotropic gelation method, the retardation of drug release from chitosan spheroids by microwave required a more complex formulation containing both stearic acid and sodium chloride unless a high stearic acid fraction was used. These spheroids demonstrated a high resistance to disintegration during dissolution owing to salt-induced bridging by sodium chloride. In response to microwave, sodium chloride aided stearic acid spread and effected domain interaction via C=O moiety over a matrix with reduced specific surface area thereby reducing drug dissolution. The drug release of spheroids can be retarded by microwave through promoting the layering of hydrophobic stearic acid in a matrix structure sustained by sodium chloride. 2010 Thesis NonPeerReviewed text en http://ir.uitm.edu.my/id/eprint/27661/1/TM_ZABLIZA%20ZAKARIA%20PH%2010_5.pdf Zakaria, Zabliza (2010) Design of controlled-release chitosan spheroids prepared by extrusion-spheronization technique using microwave / Zabliza Zakaria. Masters thesis, Universiti Teknologi MARA.
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Teknologi MARA
building	UiTM Institutional Repository
collection	Online Access
language	English
topic	Materia medica
spellingShingle	Materia medica Zakaria, Zabliza Design of controlled-release chitosan spheroids prepared by extrusion-spheronization technique using microwave / Zabliza Zakaria
description	The interplay effects of matrix formulations with microwave on drug release were investigated using an agglomerate system. Chitosan spheroids were formulated with stearic acid and/or sodium chloride by extrusion-spheronization technique, and chlorpheniramine maleate as water-soluble model drug. The spheroids were treated by microwave at 80 W for 5 to 40 min. The profiles of drug dissolution, drug content, drug-polymer interaction, polymer-polymer interaction, sodium leaching, matrix morphology and integrity were determined. Unlike chitosan matrix prepared by ionotropic gelation method, the retardation of drug release from chitosan spheroids by microwave required a more complex formulation containing both stearic acid and sodium chloride unless a high stearic acid fraction was used. These spheroids demonstrated a high resistance to disintegration during dissolution owing to salt-induced bridging by sodium chloride. In response to microwave, sodium chloride aided stearic acid spread and effected domain interaction via C=O moiety over a matrix with reduced specific surface area thereby reducing drug dissolution. The drug release of spheroids can be retarded by microwave through promoting the layering of hydrophobic stearic acid in a matrix structure sustained by sodium chloride.
format	Thesis
author	Zakaria, Zabliza
author_facet	Zakaria, Zabliza
author_sort	Zakaria, Zabliza
title	Design of controlled-release chitosan spheroids prepared by extrusion-spheronization technique using microwave / Zabliza Zakaria
title_short	Design of controlled-release chitosan spheroids prepared by extrusion-spheronization technique using microwave / Zabliza Zakaria
title_full	Design of controlled-release chitosan spheroids prepared by extrusion-spheronization technique using microwave / Zabliza Zakaria
title_fullStr	Design of controlled-release chitosan spheroids prepared by extrusion-spheronization technique using microwave / Zabliza Zakaria
title_full_unstemmed	Design of controlled-release chitosan spheroids prepared by extrusion-spheronization technique using microwave / Zabliza Zakaria
title_sort	design of controlled-release chitosan spheroids prepared by extrusion-spheronization technique using microwave / zabliza zakaria
publishDate	2010
url	http://ir.uitm.edu.my/id/eprint/27661/ http://ir.uitm.edu.my/id/eprint/27661/1/TM_ZABLIZA%20ZAKARIA%20PH%2010_5.pdf
first_indexed	2023-09-18T23:18:46Z
last_indexed	2023-09-18T23:18:46Z
_version_	1777419290141523968

Design of controlled-release chitosan spheroids prepared by extrusion-spheronization technique using microwave / Zabliza Zakaria

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