Pharmacokinetic profiles among obese and non-obese patients on valproate acid in Hospital Tengku Ampuan Rahimah: A retrospective evaluation / Nurul Husna Sodri

Pharmacokinetic profiles among obese and non-obese patients on valproate acid in Hospital Tengku Ampuan Rahimah: A retrospective evaluation / Nurul Husna Sodri

Valproic acid (VPA) is the most commonly used antiepileptic drug (AED) in Malaysia. However, studies on pharmacokinetic profiles of VPA in obese epileptic population are limited. Thus, a retrospective analysis study was conducted to evaluate the pharmacokinetic profiles’ differences between obese an...

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Main Author: Sodri, Nurul Husna
Format: Thesis
Language:English
Published: 2017
Subjects:
Drugs and their actions
Online Access:http://ir.uitm.edu.my/id/eprint/26247/
http://ir.uitm.edu.my/id/eprint/26247/1/TM_NURUL%20HUSNA%20SODRI%20PH%2017_5.pdf
id uitm-26247
recordtype eprints
spelling uitm-262472019-10-25T03:58:07Z http://ir.uitm.edu.my/id/eprint/26247/ Pharmacokinetic profiles among obese and non-obese patients on valproate acid in Hospital Tengku Ampuan Rahimah: A retrospective evaluation / Nurul Husna Sodri Sodri, Nurul Husna Drugs and their actions Valproic acid (VPA) is the most commonly used antiepileptic drug (AED) in Malaysia. However, studies on pharmacokinetic profiles of VPA in obese epileptic population are limited. Thus, a retrospective analysis study was conducted to evaluate the pharmacokinetic profiles’ differences between obese and non-obese adult patients taking VPA monotherapy. The study also evaluated the relationship between the total body weight (TBW) and ideal body weight (IBW) and the VPA clearance (CL). A total of 224 samples from the routinely collected data in Hospital Tengku Ampuan Rahimah Klang a tertiary hospital were analysed, with 109 samples grouped as obese patients and 115 as non-obese. A regression analysis was also performed in order to characterize the patient’s factors which influence VPA CL .The pharmacokinetic profiles of VPA were statistically significant difference between the two groups (p < 0.05). TBW and IBW were found to have the similar strength of relationship in determining the VPA CL and dosing regimen. The regression model for VPA CL in study population included TBW (kg) and daily dose (mg/kg/day) as factors that have significant influence. The final model was as follows: CL (L/hr) = (0.005*TBW) + (0.018*daily dose) – 0.001. In conclusion, this study demonstrated significant differences in VPA pharmacokinetic profiles between obese and non-obese patients. TBW or IBW can be used in determining the dosing regimen and the estimation of VPA CL in obese patients 2017 Thesis NonPeerReviewed text en http://ir.uitm.edu.my/id/eprint/26247/1/TM_NURUL%20HUSNA%20SODRI%20PH%2017_5.pdf Sodri, Nurul Husna (2017) Pharmacokinetic profiles among obese and non-obese patients on valproate acid in Hospital Tengku Ampuan Rahimah: A retrospective evaluation / Nurul Husna Sodri. Masters thesis, Universiti Teknologi MARA.
repository_type Digital Repository
institution_category Local University
institution Universiti Teknologi MARA
building UiTM Institutional Repository
collection Online Access
language English
topic Drugs and their actions
spellingShingle Drugs and their actions
Sodri, Nurul Husna
Pharmacokinetic profiles among obese and non-obese patients on valproate acid in Hospital Tengku Ampuan Rahimah: A retrospective evaluation / Nurul Husna Sodri
description Valproic acid (VPA) is the most commonly used antiepileptic drug (AED) in Malaysia. However, studies on pharmacokinetic profiles of VPA in obese epileptic population are limited. Thus, a retrospective analysis study was conducted to evaluate the pharmacokinetic profiles’ differences between obese and non-obese adult patients taking VPA monotherapy. The study also evaluated the relationship between the total body weight (TBW) and ideal body weight (IBW) and the VPA clearance (CL). A total of 224 samples from the routinely collected data in Hospital Tengku Ampuan Rahimah Klang a tertiary hospital were analysed, with 109 samples grouped as obese patients and 115 as non-obese. A regression analysis was also performed in order to characterize the patient’s factors which influence VPA CL .The pharmacokinetic profiles of VPA were statistically significant difference between the two groups (p < 0.05). TBW and IBW were found to have the similar strength of relationship in determining the VPA CL and dosing regimen. The regression model for VPA CL in study population included TBW (kg) and daily dose (mg/kg/day) as factors that have significant influence. The final model was as follows: CL (L/hr) = (0.005*TBW) + (0.018*daily dose) – 0.001. In conclusion, this study demonstrated significant differences in VPA pharmacokinetic profiles between obese and non-obese patients. TBW or IBW can be used in determining the dosing regimen and the estimation of VPA CL in obese patients
format Thesis
author Sodri, Nurul Husna
author_facet Sodri, Nurul Husna
author_sort Sodri, Nurul Husna
title Pharmacokinetic profiles among obese and non-obese patients on valproate acid in Hospital Tengku Ampuan Rahimah: A retrospective evaluation / Nurul Husna Sodri
title_short Pharmacokinetic profiles among obese and non-obese patients on valproate acid in Hospital Tengku Ampuan Rahimah: A retrospective evaluation / Nurul Husna Sodri
title_full Pharmacokinetic profiles among obese and non-obese patients on valproate acid in Hospital Tengku Ampuan Rahimah: A retrospective evaluation / Nurul Husna Sodri
title_fullStr Pharmacokinetic profiles among obese and non-obese patients on valproate acid in Hospital Tengku Ampuan Rahimah: A retrospective evaluation / Nurul Husna Sodri
title_full_unstemmed Pharmacokinetic profiles among obese and non-obese patients on valproate acid in Hospital Tengku Ampuan Rahimah: A retrospective evaluation / Nurul Husna Sodri
title_sort pharmacokinetic profiles among obese and non-obese patients on valproate acid in hospital tengku ampuan rahimah: a retrospective evaluation / nurul husna sodri
publishDate 2017
url http://ir.uitm.edu.my/id/eprint/26247/
http://ir.uitm.edu.my/id/eprint/26247/1/TM_NURUL%20HUSNA%20SODRI%20PH%2017_5.pdf
first_indexed 2023-09-18T23:16:29Z
last_indexed 2023-09-18T23:16:29Z
_version_ 1777419146834739200

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