The clinical outcomes of amoxicillin/clavulanate plus doxycycline versus amoxicillin/clavulanate plus azithromycin for community acquired pneumonia in cardiovascular disease patients / Norhidayah Kasiman @ Kamisan

Objective: This study was conducted to compare the clinical outcomes between amoxicillin/clavulanate plus doxycycline (AC-D) and amoxicillin/clavulanate plus azithromycin (AC-A) in cardiovascular disease patients. Methods: This was a retrospective medical review study of 282 patients with mild to mo...

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Bibliographic Details
Main Author:	Kasiman @ Kamisan, Norhidayah
Format:	Thesis
Language:	English
Published:	2016
Subjects:	RF Otorhinolaryngology Pharmaceutical dosage forms
Online Access:	http://ir.uitm.edu.my/id/eprint/26119/ http://ir.uitm.edu.my/id/eprint/26119/1/TM_NORHIDAYAH%20KASIMAN%20%40%20KAMISAN%20PH%2016_5.pdf

id	uitm-26119
recordtype	eprints
spelling	uitm-261192019-11-18T03:46:43Z http://ir.uitm.edu.my/id/eprint/26119/ The clinical outcomes of amoxicillin/clavulanate plus doxycycline versus amoxicillin/clavulanate plus azithromycin for community acquired pneumonia in cardiovascular disease patients / Norhidayah Kasiman @ Kamisan Kasiman @ Kamisan, Norhidayah RF Otorhinolaryngology Pharmaceutical dosage forms Objective: This study was conducted to compare the clinical outcomes between amoxicillin/clavulanate plus doxycycline (AC-D) and amoxicillin/clavulanate plus azithromycin (AC-A) in cardiovascular disease patients. Methods: This was a retrospective medical review study of 282 patients with mild to moderate community acquired pneumonia (CAP) admitted in general medical wards, Hospital Sultanah Nora Ismail (HSNI) from January 2014 until August 2015. Patients were divided equally into two groups based on antibiotics received within the first 48 hours of ward admission. Patient demographics, initial laboratory findings, antibiotic therapy, daily vital signs and relevant clinical outcomes were extracted from medical records. Clinical outcomes were compared between two groups of antibiotics by using appropriate statistical tests. Results: Compared to the patients treated with AC-A, those treated with AC-D had similar in time to reach clinical stability (2.32 vs. 2.12 days, p = 0.24), time to switch therapy (3.04 vs. 2.80 days, p = 0.20), hospital LOS (3.15 vs. 2.88 days, p = 0.23), rate of treatment failure (1.4% vs. 2.1%, p = 1.00), number of patients who developed QT prolongation (0% vs. 0.7%, p = 1.00) and early achievement in overall clinical outcomes (64.5% vs. 67.6%, p = 0.58). Conclusions: The use of AC-D in cardiovascular disease patients is non-inferior to AC-A. Based on these findings, the clinical effectiveness of AC-D should be evaluated prospectively. 2016 Thesis NonPeerReviewed text en http://ir.uitm.edu.my/id/eprint/26119/1/TM_NORHIDAYAH%20KASIMAN%20%40%20KAMISAN%20PH%2016_5.pdf Kasiman @ Kamisan, Norhidayah (2016) The clinical outcomes of amoxicillin/clavulanate plus doxycycline versus amoxicillin/clavulanate plus azithromycin for community acquired pneumonia in cardiovascular disease patients / Norhidayah Kasiman @ Kamisan. Masters thesis, Universiti Teknologi MARA.
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Teknologi MARA
building	UiTM Institutional Repository
collection	Online Access
language	English
topic	RF Otorhinolaryngology Pharmaceutical dosage forms
spellingShingle	RF Otorhinolaryngology Pharmaceutical dosage forms Kasiman @ Kamisan, Norhidayah The clinical outcomes of amoxicillin/clavulanate plus doxycycline versus amoxicillin/clavulanate plus azithromycin for community acquired pneumonia in cardiovascular disease patients / Norhidayah Kasiman @ Kamisan
description	Objective: This study was conducted to compare the clinical outcomes between amoxicillin/clavulanate plus doxycycline (AC-D) and amoxicillin/clavulanate plus azithromycin (AC-A) in cardiovascular disease patients. Methods: This was a retrospective medical review study of 282 patients with mild to moderate community acquired pneumonia (CAP) admitted in general medical wards, Hospital Sultanah Nora Ismail (HSNI) from January 2014 until August 2015. Patients were divided equally into two groups based on antibiotics received within the first 48 hours of ward admission. Patient demographics, initial laboratory findings, antibiotic therapy, daily vital signs and relevant clinical outcomes were extracted from medical records. Clinical outcomes were compared between two groups of antibiotics by using appropriate statistical tests. Results: Compared to the patients treated with AC-A, those treated with AC-D had similar in time to reach clinical stability (2.32 vs. 2.12 days, p = 0.24), time to switch therapy (3.04 vs. 2.80 days, p = 0.20), hospital LOS (3.15 vs. 2.88 days, p = 0.23), rate of treatment failure (1.4% vs. 2.1%, p = 1.00), number of patients who developed QT prolongation (0% vs. 0.7%, p = 1.00) and early achievement in overall clinical outcomes (64.5% vs. 67.6%, p = 0.58). Conclusions: The use of AC-D in cardiovascular disease patients is non-inferior to AC-A. Based on these findings, the clinical effectiveness of AC-D should be evaluated prospectively.
format	Thesis
author	Kasiman @ Kamisan, Norhidayah
author_facet	Kasiman @ Kamisan, Norhidayah
author_sort	Kasiman @ Kamisan, Norhidayah
title	The clinical outcomes of amoxicillin/clavulanate plus doxycycline versus amoxicillin/clavulanate plus azithromycin for community acquired pneumonia in cardiovascular disease patients / Norhidayah Kasiman @ Kamisan
title_short	The clinical outcomes of amoxicillin/clavulanate plus doxycycline versus amoxicillin/clavulanate plus azithromycin for community acquired pneumonia in cardiovascular disease patients / Norhidayah Kasiman @ Kamisan
title_full	The clinical outcomes of amoxicillin/clavulanate plus doxycycline versus amoxicillin/clavulanate plus azithromycin for community acquired pneumonia in cardiovascular disease patients / Norhidayah Kasiman @ Kamisan
title_fullStr	The clinical outcomes of amoxicillin/clavulanate plus doxycycline versus amoxicillin/clavulanate plus azithromycin for community acquired pneumonia in cardiovascular disease patients / Norhidayah Kasiman @ Kamisan
title_full_unstemmed	The clinical outcomes of amoxicillin/clavulanate plus doxycycline versus amoxicillin/clavulanate plus azithromycin for community acquired pneumonia in cardiovascular disease patients / Norhidayah Kasiman @ Kamisan
title_sort	clinical outcomes of amoxicillin/clavulanate plus doxycycline versus amoxicillin/clavulanate plus azithromycin for community acquired pneumonia in cardiovascular disease patients / norhidayah kasiman @ kamisan
publishDate	2016
url	http://ir.uitm.edu.my/id/eprint/26119/ http://ir.uitm.edu.my/id/eprint/26119/1/TM_NORHIDAYAH%20KASIMAN%20%40%20KAMISAN%20PH%2016_5.pdf
first_indexed	2023-09-18T23:16:13Z
last_indexed	2023-09-18T23:16:13Z
_version_	1777419129499680768

The clinical outcomes of amoxicillin/clavulanate plus doxycycline versus amoxicillin/clavulanate plus azithromycin for community acquired pneumonia in cardiovascular disease patients / Norhidayah Kasiman @ Kamisan

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