Herb-in vitro cyp interaction of Cytochrome P1A2 on Malaysian traditional herbs / Nur Amirah Mohd Noor Azami

Many people believe that traditional medicine can be use as alternative to treat many diseases and some of them take both medicines at same time. They do not notice that there have risks of interactions between herbs and drug leading to toxicity or loss of therapeutic efficacy. The purpose of thi...

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Main Author:	Mohd Noor Azami, Nur Amirah
Format:	Thesis
Language:	English
Published:	Faculty of Pharmacy 2010
Subjects:	Medical botany (General) RM Therapeutics. Pharmacology
Online Access:	http://ir.uitm.edu.my/id/eprint/2247/ http://ir.uitm.edu.my/id/eprint/2247/1/TD_NUR%20AMIRAH%20MOHD%20NOOR%20AZAMI%20PH%2010_5.pdf

id	uitm-2247
recordtype	eprints
spelling	uitm-22472017-08-03T04:18:06Z http://ir.uitm.edu.my/id/eprint/2247/ Herb-in vitro cyp interaction of Cytochrome P1A2 on Malaysian traditional herbs / Nur Amirah Mohd Noor Azami Mohd Noor Azami, Nur Amirah Medical botany (General) RM Therapeutics. Pharmacology Many people believe that traditional medicine can be use as alternative to treat many diseases and some of them take both medicines at same time. They do not notice that there have risks of interactions between herbs and drug leading to toxicity or loss of therapeutic efficacy. The purpose of this study is to evaluate the interactions of Malaysian traditional herbs with CYP1A2 enzymes. CYP1A2 is one of the major member of CYP and it constitute about 12-20% of the total CYP content and it mostly a hepatic enzymes. Vivid®CYP450 Screening Kit had been use to study the inhibition activity of Malaysian traditional herbs. α-naphthoflavone is use as positive control that showed 100% inhibition and solvents control which is DMSO showed 0% inhibition or no inhibition. Result showed 27 herb which are Biji kedaung, Bunga mukmin, Cabai pintal, Getah katira, Halba, Kadukai besar, Kadukai kecil, Kacip Fatimah, Kayu angin, Kayu lilit, Ketumbar, Kulit kayu manis, Lada pahit, Lebai samad, Lengkuas, Manjalawi, Mas cotek, Pakawali, Pegaga, Pinang, Pulau waras sari, Selasih, Sembaranthu, Senduduk, Serai wangi, Tenggek burung and Tering pipit show inhibitions at concentration 0.1mg/ml. From 56 Malaysian traditional herbs species, there are 27 herbs shown inhibition on concentration 1 mg/ml which is Kulit kayu manis, Pulau waras sari, Sembaranthu and Senduduk. Other herbs do not show any significant inhibition. Keywords: CYP1A2, Malaysian traditional herb, inhibition Faculty of Pharmacy 2010 Thesis NonPeerReviewed text en http://ir.uitm.edu.my/id/eprint/2247/1/TD_NUR%20AMIRAH%20MOHD%20NOOR%20AZAMI%20PH%2010_5.pdf Mohd Noor Azami, Nur Amirah (2010) Herb-in vitro cyp interaction of Cytochrome P1A2 on Malaysian traditional herbs / Nur Amirah Mohd Noor Azami. Degree thesis, Universiti Teknologi MARA.
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Teknologi MARA
building	UiTM Institutional Repository
collection	Online Access
language	English
topic	Medical botany (General) RM Therapeutics. Pharmacology
spellingShingle	Medical botany (General) RM Therapeutics. Pharmacology Mohd Noor Azami, Nur Amirah Herb-in vitro cyp interaction of Cytochrome P1A2 on Malaysian traditional herbs / Nur Amirah Mohd Noor Azami
description	Many people believe that traditional medicine can be use as alternative to treat many diseases and some of them take both medicines at same time. They do not notice that there have risks of interactions between herbs and drug leading to toxicity or loss of therapeutic efficacy. The purpose of this study is to evaluate the interactions of Malaysian traditional herbs with CYP1A2 enzymes. CYP1A2 is one of the major member of CYP and it constitute about 12-20% of the total CYP content and it mostly a hepatic enzymes. Vivid®CYP450 Screening Kit had been use to study the inhibition activity of Malaysian traditional herbs. α-naphthoflavone is use as positive control that showed 100% inhibition and solvents control which is DMSO showed 0% inhibition or no inhibition. Result showed 27 herb which are Biji kedaung, Bunga mukmin, Cabai pintal, Getah katira, Halba, Kadukai besar, Kadukai kecil, Kacip Fatimah, Kayu angin, Kayu lilit, Ketumbar, Kulit kayu manis, Lada pahit, Lebai samad, Lengkuas, Manjalawi, Mas cotek, Pakawali, Pegaga, Pinang, Pulau waras sari, Selasih, Sembaranthu, Senduduk, Serai wangi, Tenggek burung and Tering pipit show inhibitions at concentration 0.1mg/ml. From 56 Malaysian traditional herbs species, there are 27 herbs shown inhibition on concentration 1 mg/ml which is Kulit kayu manis, Pulau waras sari, Sembaranthu and Senduduk. Other herbs do not show any significant inhibition. Keywords: CYP1A2, Malaysian traditional herb, inhibition
format	Thesis
author	Mohd Noor Azami, Nur Amirah
author_facet	Mohd Noor Azami, Nur Amirah
author_sort	Mohd Noor Azami, Nur Amirah
title	Herb-in vitro cyp interaction of Cytochrome P1A2 on Malaysian traditional herbs / Nur Amirah Mohd Noor Azami
title_short	Herb-in vitro cyp interaction of Cytochrome P1A2 on Malaysian traditional herbs / Nur Amirah Mohd Noor Azami
title_full	Herb-in vitro cyp interaction of Cytochrome P1A2 on Malaysian traditional herbs / Nur Amirah Mohd Noor Azami
title_fullStr	Herb-in vitro cyp interaction of Cytochrome P1A2 on Malaysian traditional herbs / Nur Amirah Mohd Noor Azami
title_full_unstemmed	Herb-in vitro cyp interaction of Cytochrome P1A2 on Malaysian traditional herbs / Nur Amirah Mohd Noor Azami
title_sort	herb-in vitro cyp interaction of cytochrome p1a2 on malaysian traditional herbs / nur amirah mohd noor azami
publisher	Faculty of Pharmacy
publishDate	2010
url	http://ir.uitm.edu.my/id/eprint/2247/ http://ir.uitm.edu.my/id/eprint/2247/1/TD_NUR%20AMIRAH%20MOHD%20NOOR%20AZAMI%20PH%2010_5.pdf
first_indexed	2023-09-18T22:46:27Z
last_indexed	2023-09-18T22:46:27Z
_version_	1777417256775450624

Herb-in vitro cyp interaction of Cytochrome P1A2 on Malaysian traditional herbs / Nur Amirah Mohd Noor Azami

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