Phytochemical studies of Gnetum Microcarpum, Gnetum Cuspidatum, Cynometra cauliflora, Bouea oppositifolia and their biological activities / Nik Fatini Nik Azmin

Phytochemical studies of Gnetum Microcarpum, Gnetum Cuspidatum, Cynometra cauliflora, Bouea oppositifolia and their biological activities / Nik Fatini Nik Azmin

In the present work, phytochemical and pharmacological studies were conducted on four species of plants from three different families. The studied plant samples were the air-dried lianas of two species from Gnetaceae family which are Gnetum microcarpum Blume and Gnetum cuspidatum Blume and the twigs...

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Main Author: Nik Azmin, Nik Fatini
Format: Book Section
Language:English
Published: Institute of Graduate Studies, UiTM 2018
Subjects:
Immunology
Online Access:http://ir.uitm.edu.my/id/eprint/22025/
http://ir.uitm.edu.my/id/eprint/22025/1/ABS_NIK%20FATINI%20NIK%20AZMIN%20TDRA%20VOL%2014%20IGS%2018.pdf
id uitm-22025
recordtype eprints
spelling uitm-220252018-11-12T06:57:56Z http://ir.uitm.edu.my/id/eprint/22025/ Phytochemical studies of Gnetum Microcarpum, Gnetum Cuspidatum, Cynometra cauliflora, Bouea oppositifolia and their biological activities / Nik Fatini Nik Azmin Nik Azmin, Nik Fatini Immunology In the present work, phytochemical and pharmacological studies were conducted on four species of plants from three different families. The studied plant samples were the air-dried lianas of two species from Gnetaceae family which are Gnetum microcarpum Blume and Gnetum cuspidatum Blume and the twigs of Cynometra cauliflora Linn from the family of Fabacaeae and Bouea oppositifolia (Roxb.) Meisn from the family of Anacardiaceae. The aims of this study are to isolate the secondary metabolites from the plants, to propose biogenetic pathway of the new isolated compounds, to determine their DPPH scavenging, PGE2 inhibitory and cytotoxic activities and to study the Structure-Activity Relationship (SAR). The isolation process was done by conventional method of maceration, fractionation, separation and purification using several chromatographic techniques and structural elucidation was based on the spectroscopic data evidences and comparison with reported authentic data. Phytochemicals investigation on the lianas of the two Gnetum species yielded 11 known stilbenoid compounds; resveratrol (1), isorhapontigenin (3), gnetol (10), gnetifolin P (18), gnetofuran C (20), gnetucleistol C (21), cuspidan B (24), e-viniferin (31), parvifolol D (44), gnemonol M (48) and malaysianol D (388), two new compounds from G. microcarpum characterized as malaysianol E (25), malaysianol F (389) and one new compound from G. cuspidatum, namely malaysianol G (399). Phytochemicals investigation on C. cauliflora and B. oppositifolia gave 16 known flavonoid compounds; naringenin (263) and eriodictyol (262) were obtained from both species; flavone apigenin, acacetin, luteolin, luteolin 3',5 dimethyl ether, 3',4',7-trihydroxyflavone, 4',7-dihydroxyflavone (392-397) and 5,7-dihydroxychromone (391) from C. cauliflora; chalcone isoliquiritigenin (398), flavanone liquiritigenin and butin (399-400), flavanol taxifolin (260), fustin, garbanzol (401-402) and aurone sulfuretin (403) from B. oppositifolia… Institute of Graduate Studies, UiTM 2018 Book Section PeerReviewed text en http://ir.uitm.edu.my/id/eprint/22025/1/ABS_NIK%20FATINI%20NIK%20AZMIN%20TDRA%20VOL%2014%20IGS%2018.pdf Nik Azmin, Nik Fatini (2018) Phytochemical studies of Gnetum Microcarpum, Gnetum Cuspidatum, Cynometra cauliflora, Bouea oppositifolia and their biological activities / Nik Fatini Nik Azmin. In: The Doctoral Research Abstracts. IGS Biannual Publication, 14 . Institute of Graduate Studies, UiTM, Shah Alam.
repository_type Digital Repository
institution_category Local University
institution Universiti Teknologi MARA
building UiTM Institutional Repository
collection Online Access
language English
topic Immunology
spellingShingle Immunology
Nik Azmin, Nik Fatini
Phytochemical studies of Gnetum Microcarpum, Gnetum Cuspidatum, Cynometra cauliflora, Bouea oppositifolia and their biological activities / Nik Fatini Nik Azmin
description In the present work, phytochemical and pharmacological studies were conducted on four species of plants from three different families. The studied plant samples were the air-dried lianas of two species from Gnetaceae family which are Gnetum microcarpum Blume and Gnetum cuspidatum Blume and the twigs of Cynometra cauliflora Linn from the family of Fabacaeae and Bouea oppositifolia (Roxb.) Meisn from the family of Anacardiaceae. The aims of this study are to isolate the secondary metabolites from the plants, to propose biogenetic pathway of the new isolated compounds, to determine their DPPH scavenging, PGE2 inhibitory and cytotoxic activities and to study the Structure-Activity Relationship (SAR). The isolation process was done by conventional method of maceration, fractionation, separation and purification using several chromatographic techniques and structural elucidation was based on the spectroscopic data evidences and comparison with reported authentic data. Phytochemicals investigation on the lianas of the two Gnetum species yielded 11 known stilbenoid compounds; resveratrol (1), isorhapontigenin (3), gnetol (10), gnetifolin P (18), gnetofuran C (20), gnetucleistol C (21), cuspidan B (24), e-viniferin (31), parvifolol D (44), gnemonol M (48) and malaysianol D (388), two new compounds from G. microcarpum characterized as malaysianol E (25), malaysianol F (389) and one new compound from G. cuspidatum, namely malaysianol G (399). Phytochemicals investigation on C. cauliflora and B. oppositifolia gave 16 known flavonoid compounds; naringenin (263) and eriodictyol (262) were obtained from both species; flavone apigenin, acacetin, luteolin, luteolin 3',5 dimethyl ether, 3',4',7-trihydroxyflavone, 4',7-dihydroxyflavone (392-397) and 5,7-dihydroxychromone (391) from C. cauliflora; chalcone isoliquiritigenin (398), flavanone liquiritigenin and butin (399-400), flavanol taxifolin (260), fustin, garbanzol (401-402) and aurone sulfuretin (403) from B. oppositifolia…
format Book Section
author Nik Azmin, Nik Fatini
author_facet Nik Azmin, Nik Fatini
author_sort Nik Azmin, Nik Fatini
title Phytochemical studies of Gnetum Microcarpum, Gnetum Cuspidatum, Cynometra cauliflora, Bouea oppositifolia and their biological activities / Nik Fatini Nik Azmin
title_short Phytochemical studies of Gnetum Microcarpum, Gnetum Cuspidatum, Cynometra cauliflora, Bouea oppositifolia and their biological activities / Nik Fatini Nik Azmin
title_full Phytochemical studies of Gnetum Microcarpum, Gnetum Cuspidatum, Cynometra cauliflora, Bouea oppositifolia and their biological activities / Nik Fatini Nik Azmin
title_fullStr Phytochemical studies of Gnetum Microcarpum, Gnetum Cuspidatum, Cynometra cauliflora, Bouea oppositifolia and their biological activities / Nik Fatini Nik Azmin
title_full_unstemmed Phytochemical studies of Gnetum Microcarpum, Gnetum Cuspidatum, Cynometra cauliflora, Bouea oppositifolia and their biological activities / Nik Fatini Nik Azmin
title_sort phytochemical studies of gnetum microcarpum, gnetum cuspidatum, cynometra cauliflora, bouea oppositifolia and their biological activities / nik fatini nik azmin
publisher Institute of Graduate Studies, UiTM
publishDate 2018
url http://ir.uitm.edu.my/id/eprint/22025/
http://ir.uitm.edu.my/id/eprint/22025/1/ABS_NIK%20FATINI%20NIK%20AZMIN%20TDRA%20VOL%2014%20IGS%2018.pdf
first_indexed 2023-09-18T23:07:45Z
last_indexed 2023-09-18T23:07:45Z
_version_ 1777418597152325632

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