Bioassay-guided isolation of antiplasmodial compounds from two Malaysian Kopsia species / Nor Hadiani Ismail, Khalijah Awang and Faridahanim Mohd Jaafar

In our search for antiplasmodial compounds from Malaysian plants, two plants from genus Kopsia (family Annonaceae) that are Kopsia terengganensis and Kopsia teoi were investigated. Based on the traditional use of this plant for treating fever, we had carried out the study on the antiplasmodial effec...

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Main Authors:	Ismail, Nor Hadiani, Awang, Khalijah, Mohd Jaafar, Faridahanim
Format:	Research Reports
Language:	English
Published:	Research Management Institute (RMI) 2010
Subjects:	Medicinal plants (Culture only) Flowers and flower culture. Ornamental plants Wild plants. Wild flowers. Native plants
Online Access:	http://ir.uitm.edu.my/id/eprint/21006/ http://ir.uitm.edu.my/id/eprint/21006/1/LP_NOR%20HADIANI%20ISMAIL%20RMI%2010_5.pdf

id	uitm-21006
recordtype	eprints
spelling	uitm-210062018-10-08T04:06:25Z http://ir.uitm.edu.my/id/eprint/21006/ Bioassay-guided isolation of antiplasmodial compounds from two Malaysian Kopsia species / Nor Hadiani Ismail, Khalijah Awang and Faridahanim Mohd Jaafar Ismail, Nor Hadiani Awang, Khalijah Mohd Jaafar, Faridahanim Medicinal plants (Culture only) Flowers and flower culture. Ornamental plants Wild plants. Wild flowers. Native plants In our search for antiplasmodial compounds from Malaysian plants, two plants from genus Kopsia (family Annonaceae) that are Kopsia terengganensis and Kopsia teoi were investigated. Based on the traditional use of this plant for treating fever, we had carried out the study on the antiplasmodial effect of Kopsia terengganensis. This study was undertaken to investigate the possibility of antimalarial activity of K terengganensis and K teoi. by isolating of the phytochemicals from the extracts and active fractions of K terengganensis and K teoi, identifying the structures of the purified phytochemicals using spectroscopic methods and determining the antiplasmodial activity. Chromatographic separation and isolation procedures on K terenganensis yielded the alkaloids larutensine (1), eburnamine (2), akuammidine (3), eburnaminol (4), rhazidigenine (5), quebrachamine (6), isoeburnamine (7) and eburnamonine (8). From Kopsia teoi, rhazimol (9), kopsinginol (10), kopsigine (11), ebumamenine (12), akuammiline (13), isoeburnamine (7) and kopsinol (14) were obtained. Compounds coded 5011-14 CRYS, 3P2, RJ-18 and 5035 H₂0 showed strong inhibition with IC50 values below 5 μg/mL. The strongest inhibition was shown by compound 5011-14 CRYS with IC₅₀ 0.11 μg/mL. Compounds RAW1 and 5035 H CRYS showed moderate inhibition with IC₅₀ values of 10.09 and 16.72 μg/ml, respectively. Further work on these compounds is being pursued based on the promising activities shown. This data suggests that K terengganensis and K. teoi are potential source of antimalarial agents. Research Management Institute (RMI) 2010 Research Reports NonPeerReviewed text en http://ir.uitm.edu.my/id/eprint/21006/1/LP_NOR%20HADIANI%20ISMAIL%20RMI%2010_5.pdf Ismail, Nor Hadiani and Awang, Khalijah and Mohd Jaafar, Faridahanim (2010) Bioassay-guided isolation of antiplasmodial compounds from two Malaysian Kopsia species / Nor Hadiani Ismail, Khalijah Awang and Faridahanim Mohd Jaafar. [Research Reports] (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Teknologi MARA
building	UiTM Institutional Repository
collection	Online Access
language	English
topic	Medicinal plants (Culture only) Flowers and flower culture. Ornamental plants Wild plants. Wild flowers. Native plants
spellingShingle	Medicinal plants (Culture only) Flowers and flower culture. Ornamental plants Wild plants. Wild flowers. Native plants Ismail, Nor Hadiani Awang, Khalijah Mohd Jaafar, Faridahanim Bioassay-guided isolation of antiplasmodial compounds from two Malaysian Kopsia species / Nor Hadiani Ismail, Khalijah Awang and Faridahanim Mohd Jaafar
description	In our search for antiplasmodial compounds from Malaysian plants, two plants from genus Kopsia (family Annonaceae) that are Kopsia terengganensis and Kopsia teoi were investigated. Based on the traditional use of this plant for treating fever, we had carried out the study on the antiplasmodial effect of Kopsia terengganensis. This study was undertaken to investigate the possibility of antimalarial activity of K terengganensis and K teoi. by isolating of the phytochemicals from the extracts and active fractions of K terengganensis and K teoi, identifying the structures of the purified phytochemicals using spectroscopic methods and determining the antiplasmodial activity. Chromatographic separation and isolation procedures on K terenganensis yielded the alkaloids larutensine (1), eburnamine (2), akuammidine (3), eburnaminol (4), rhazidigenine (5), quebrachamine (6), isoeburnamine (7) and eburnamonine (8). From Kopsia teoi, rhazimol (9), kopsinginol (10), kopsigine (11), ebumamenine (12), akuammiline (13), isoeburnamine (7) and kopsinol (14) were obtained. Compounds coded 5011-14 CRYS, 3P2, RJ-18 and 5035 H₂0 showed strong inhibition with IC50 values below 5 μg/mL. The strongest inhibition was shown by compound 5011-14 CRYS with IC₅₀ 0.11 μg/mL. Compounds RAW1 and 5035 H CRYS showed moderate inhibition with IC₅₀ values of 10.09 and 16.72 μg/ml, respectively. Further work on these compounds is being pursued based on the promising activities shown. This data suggests that K terengganensis and K. teoi are potential source of antimalarial agents.
format	Research Reports
author	Ismail, Nor Hadiani Awang, Khalijah Mohd Jaafar, Faridahanim
author_facet	Ismail, Nor Hadiani Awang, Khalijah Mohd Jaafar, Faridahanim
author_sort	Ismail, Nor Hadiani
title	Bioassay-guided isolation of antiplasmodial compounds from two Malaysian Kopsia species / Nor Hadiani Ismail, Khalijah Awang and Faridahanim Mohd Jaafar
title_short	Bioassay-guided isolation of antiplasmodial compounds from two Malaysian Kopsia species / Nor Hadiani Ismail, Khalijah Awang and Faridahanim Mohd Jaafar
title_full	Bioassay-guided isolation of antiplasmodial compounds from two Malaysian Kopsia species / Nor Hadiani Ismail, Khalijah Awang and Faridahanim Mohd Jaafar
title_fullStr	Bioassay-guided isolation of antiplasmodial compounds from two Malaysian Kopsia species / Nor Hadiani Ismail, Khalijah Awang and Faridahanim Mohd Jaafar
title_full_unstemmed	Bioassay-guided isolation of antiplasmodial compounds from two Malaysian Kopsia species / Nor Hadiani Ismail, Khalijah Awang and Faridahanim Mohd Jaafar
title_sort	bioassay-guided isolation of antiplasmodial compounds from two malaysian kopsia species / nor hadiani ismail, khalijah awang and faridahanim mohd jaafar
publisher	Research Management Institute (RMI)
publishDate	2010
url	http://ir.uitm.edu.my/id/eprint/21006/ http://ir.uitm.edu.my/id/eprint/21006/1/LP_NOR%20HADIANI%20ISMAIL%20RMI%2010_5.pdf
first_indexed	2023-09-18T23:05:37Z
last_indexed	2023-09-18T23:05:37Z
_version_	1777418463273287680

Bioassay-guided isolation of antiplasmodial compounds from two Malaysian Kopsia species / Nor Hadiani Ismail, Khalijah Awang and Faridahanim Mohd Jaafar

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