p53 protein expression and risk factors in breast cancer – a retrospective study / Rashidah Shahruddin

Numerous studies showed that overexpression of p53 protein may be involved in a variety of human malignancies including breast cancer. In breast cancer patients, a mutated p53 gene that encodes the p53 protein is associated with a higher risk of carcinogenesis and this study examine the potential ro...

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Main Author:	Shahruddin, Rashidah
Format:	Book Section
Language:	English
Published:	Institute of Graduate Studies, UiTM 2017
Subjects:	Malaysia Diseases of the breast
Online Access:	http://ir.uitm.edu.my/id/eprint/19931/ http://ir.uitm.edu.my/id/eprint/19931/1/ABS_RASHIDAH%20SHAHRUDDIN%20TDRA%20VOL%2012%20IGS%2017.pdf

id	uitm-19931
recordtype	eprints
spelling	uitm-199312018-06-11T02:55:01Z http://ir.uitm.edu.my/id/eprint/19931/ p53 protein expression and risk factors in breast cancer – a retrospective study / Rashidah Shahruddin Shahruddin, Rashidah Malaysia Diseases of the breast Numerous studies showed that overexpression of p53 protein may be involved in a variety of human malignancies including breast cancer. In breast cancer patients, a mutated p53 gene that encodes the p53 protein is associated with a higher risk of carcinogenesis and this study examine the potential role of p53 status in breast cancer tissues, specifically its association to established risk factors race, age, age at menarche, hormonal factors and cancer grade. The immunohistochemistry (IHC) technique was used to detect overexpression characteristics of p53 protein and the immunohistochemical results were compared with established risk factors. Analysis conducted on 111 breast tissues showed 40% (44/111) positive p53 (+) protein and 60% (67/111) nonexpression p53 (-) respectively. Malay occupied nearly half the number of respondents for overexpressed and nonexpression of p53 (+,-) protein (n=53, 48%) followed by Chinese (n=30, 27%) and Indian (n=28, 25%) with no significant difference (p> 0.05). Overexpression of p53 (+) protein occurred in 37% (41/111) of the premenopausal age group above 40 years old and 3% (3/111) in the age group less than 40 years old (p> 0.05). The probability of p53 (+) protein being overexpressed in the age group less than 40 years old is 0.66 RR 0.665(CI :0.246- 1.796) times less likely compared to age group above 41 years old. Institute of Graduate Studies, UiTM 2017 Book Section PeerReviewed text en http://ir.uitm.edu.my/id/eprint/19931/1/ABS_RASHIDAH%20SHAHRUDDIN%20TDRA%20VOL%2012%20IGS%2017.pdf Shahruddin, Rashidah (2017) p53 protein expression and risk factors in breast cancer – a retrospective study / Rashidah Shahruddin. In: The Doctoral Research Abstracts. IGS Biannual Publication, 12 (12). Institute of Graduate Studies, UiTM, Shah Alam.
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Teknologi MARA
building	UiTM Institutional Repository
collection	Online Access
language	English
topic	Malaysia Diseases of the breast
spellingShingle	Malaysia Diseases of the breast Shahruddin, Rashidah p53 protein expression and risk factors in breast cancer – a retrospective study / Rashidah Shahruddin
description	Numerous studies showed that overexpression of p53 protein may be involved in a variety of human malignancies including breast cancer. In breast cancer patients, a mutated p53 gene that encodes the p53 protein is associated with a higher risk of carcinogenesis and this study examine the potential role of p53 status in breast cancer tissues, specifically its association to established risk factors race, age, age at menarche, hormonal factors and cancer grade. The immunohistochemistry (IHC) technique was used to detect overexpression characteristics of p53 protein and the immunohistochemical results were compared with established risk factors. Analysis conducted on 111 breast tissues showed 40% (44/111) positive p53 (+) protein and 60% (67/111) nonexpression p53 (-) respectively. Malay occupied nearly half the number of respondents for overexpressed and nonexpression of p53 (+,-) protein (n=53, 48%) followed by Chinese (n=30, 27%) and Indian (n=28, 25%) with no significant difference (p> 0.05). Overexpression of p53 (+) protein occurred in 37% (41/111) of the premenopausal age group above 40 years old and 3% (3/111) in the age group less than 40 years old (p> 0.05). The probability of p53 (+) protein being overexpressed in the age group less than 40 years old is 0.66 RR 0.665(CI :0.246- 1.796) times less likely compared to age group above 41 years old.
format	Book Section
author	Shahruddin, Rashidah
author_facet	Shahruddin, Rashidah
author_sort	Shahruddin, Rashidah
title	p53 protein expression and risk factors in breast cancer – a retrospective study / Rashidah Shahruddin
title_short	p53 protein expression and risk factors in breast cancer – a retrospective study / Rashidah Shahruddin
title_full	p53 protein expression and risk factors in breast cancer – a retrospective study / Rashidah Shahruddin
title_fullStr	p53 protein expression and risk factors in breast cancer – a retrospective study / Rashidah Shahruddin
title_full_unstemmed	p53 protein expression and risk factors in breast cancer – a retrospective study / Rashidah Shahruddin
title_sort	p53 protein expression and risk factors in breast cancer – a retrospective study / rashidah shahruddin
publisher	Institute of Graduate Studies, UiTM
publishDate	2017
url	http://ir.uitm.edu.my/id/eprint/19931/ http://ir.uitm.edu.my/id/eprint/19931/1/ABS_RASHIDAH%20SHAHRUDDIN%20TDRA%20VOL%2012%20IGS%2017.pdf
first_indexed	2023-09-18T23:03:36Z
last_indexed	2023-09-18T23:03:36Z
_version_	1777418335939461120

p53 protein expression and risk factors in breast cancer – a retrospective study / Rashidah Shahruddin

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