Interpatient variability in tamoxifen respone among breast cancer patient: the use of pharmacogenetics and metabolomics in closing the gaps in clinical practice / Nor Izwani Mohamed

Tamoxifen has been widely used as the standard adjuvant therapy for breast cancer patients with oestrogen receptor-positive status, especially in the highrisk pre- and postmenopausal women. However, 30 to 50% of ER-positive breast cancer patients do not respond to tamoxifen therapy. Major challenges...

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Main Author:	Mohamed, Nor Izwani
Format:	Book Section
Language:	English
Published:	Institute of Graduate Studies, UiTM 2017
Subjects:	Malaysia Research. Experimentation
Online Access:	http://ir.uitm.edu.my/id/eprint/19903/ http://ir.uitm.edu.my/id/eprint/19903/1/ABS_NOR%20IZWANI%20MOHAMED%20TDRA%20VOL%2012%20IGS%2017.pdf

id	uitm-19903
recordtype	eprints
spelling	uitm-199032018-06-08T03:55:10Z http://ir.uitm.edu.my/id/eprint/19903/ Interpatient variability in tamoxifen respone among breast cancer patient: the use of pharmacogenetics and metabolomics in closing the gaps in clinical practice / Nor Izwani Mohamed Mohamed, Nor Izwani Malaysia Research. Experimentation Tamoxifen has been widely used as the standard adjuvant therapy for breast cancer patients with oestrogen receptor-positive status, especially in the highrisk pre- and postmenopausal women. However, 30 to 50% of ER-positive breast cancer patients do not respond to tamoxifen therapy. Major challenges to effective tamoxifen therapy include drug resistance, and adverse events. Thus, this study aims to investigate the impact of pharmacogenomics and metabolomics in monitoring the efficacy of tamoxifen treatment in BRCA patients. A total of 95 tamoxifen-treated patients, and 11 untreated breast cancer patients from three major Malaysian ethnic groups (Malay, Chinese and Indian) were recruited. However, only 84 tamoxifen-treated patients with completed clinical data were included for clinical association analysis. Institute of Graduate Studies, UiTM 2017 Book Section PeerReviewed text en http://ir.uitm.edu.my/id/eprint/19903/1/ABS_NOR%20IZWANI%20MOHAMED%20TDRA%20VOL%2012%20IGS%2017.pdf Mohamed, Nor Izwani (2017) Interpatient variability in tamoxifen respone among breast cancer patient: the use of pharmacogenetics and metabolomics in closing the gaps in clinical practice / Nor Izwani Mohamed. In: The Doctoral Research Abstracts. IGS Biannual Publication, 12 (12). Institute of Graduate Studies, UiTM, Shah Alam.
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Teknologi MARA
building	UiTM Institutional Repository
collection	Online Access
language	English
topic	Malaysia Research. Experimentation
spellingShingle	Malaysia Research. Experimentation Mohamed, Nor Izwani Interpatient variability in tamoxifen respone among breast cancer patient: the use of pharmacogenetics and metabolomics in closing the gaps in clinical practice / Nor Izwani Mohamed
description	Tamoxifen has been widely used as the standard adjuvant therapy for breast cancer patients with oestrogen receptor-positive status, especially in the highrisk pre- and postmenopausal women. However, 30 to 50% of ER-positive breast cancer patients do not respond to tamoxifen therapy. Major challenges to effective tamoxifen therapy include drug resistance, and adverse events. Thus, this study aims to investigate the impact of pharmacogenomics and metabolomics in monitoring the efficacy of tamoxifen treatment in BRCA patients. A total of 95 tamoxifen-treated patients, and 11 untreated breast cancer patients from three major Malaysian ethnic groups (Malay, Chinese and Indian) were recruited. However, only 84 tamoxifen-treated patients with completed clinical data were included for clinical association analysis.
format	Book Section
author	Mohamed, Nor Izwani
author_facet	Mohamed, Nor Izwani
author_sort	Mohamed, Nor Izwani
title	Interpatient variability in tamoxifen respone among breast cancer patient: the use of pharmacogenetics and metabolomics in closing the gaps in clinical practice / Nor Izwani Mohamed
title_short	Interpatient variability in tamoxifen respone among breast cancer patient: the use of pharmacogenetics and metabolomics in closing the gaps in clinical practice / Nor Izwani Mohamed
title_full	Interpatient variability in tamoxifen respone among breast cancer patient: the use of pharmacogenetics and metabolomics in closing the gaps in clinical practice / Nor Izwani Mohamed
title_fullStr	Interpatient variability in tamoxifen respone among breast cancer patient: the use of pharmacogenetics and metabolomics in closing the gaps in clinical practice / Nor Izwani Mohamed
title_full_unstemmed	Interpatient variability in tamoxifen respone among breast cancer patient: the use of pharmacogenetics and metabolomics in closing the gaps in clinical practice / Nor Izwani Mohamed
title_sort	interpatient variability in tamoxifen respone among breast cancer patient: the use of pharmacogenetics and metabolomics in closing the gaps in clinical practice / nor izwani mohamed
publisher	Institute of Graduate Studies, UiTM
publishDate	2017
url	http://ir.uitm.edu.my/id/eprint/19903/ http://ir.uitm.edu.my/id/eprint/19903/1/ABS_NOR%20IZWANI%20MOHAMED%20TDRA%20VOL%2012%20IGS%2017.pdf
first_indexed	2023-09-18T23:03:32Z
last_indexed	2023-09-18T23:03:32Z
_version_	1777418331884617728

Interpatient variability in tamoxifen respone among breast cancer patient: the use of pharmacogenetics and metabolomics in closing the gaps in clinical practice / Nor Izwani Mohamed

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