Antimicrobial activities and enhancers of DNA gyrase inhibitors from manure compost actinomycetes / Anis Low Muhammad Low

Antimicrobial activities and enhancers of DNA gyrase inhibitors from manure compost actinomycetes / Anis Low Muhammad Low

Actinomycetes are invaluable sources of bioactive microbial compounds and have been the central of novel drug research as they continuously contribute to the pharmaceutical industry. The traditional perception of actinomycetes being soil bound has currently changed with evidence demonstrating their...

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Main Author: Muhammad Low, Anis Low
Format: Book Section
Language:English
Published: Institute of Graduate Studies, UiTM 2016
Subjects:
Malaysia
Online Access:http://ir.uitm.edu.my/id/eprint/19902/
http://ir.uitm.edu.my/id/eprint/19902/1/ABS_ANIS%20LOW%20MUHAMMAD%20LOW%20TDRA%20VOL%2010%20IGS%2016.pdf
id uitm-19902
recordtype eprints
spelling uitm-199022018-06-08T03:53:51Z http://ir.uitm.edu.my/id/eprint/19902/ Antimicrobial activities and enhancers of DNA gyrase inhibitors from manure compost actinomycetes / Anis Low Muhammad Low Muhammad Low, Anis Low Malaysia Actinomycetes are invaluable sources of bioactive microbial compounds and have been the central of novel drug research as they continuously contribute to the pharmaceutical industry. The traditional perception of actinomycetes being soil bound has currently changed with evidence demonstrating their colonization in unique microenvironment. Through evolution and environmental adaptation, development of unusual metabolic activities has resulted in a variety of anti-infective agents from these bacteria. Nevertheless, the discovery of actinomycetes and its bioactive secondary metabolites from manure compost materials remained understudied. This research was therefore undertaken with the aim of isolating and characterizing the diversity of actinomycetes from manure composts, identifying morphologically distinct isolates, screening isolates for potential antimicrobial activities and bioactive compounds which act as enhancers for DNA gyrase inhibitor as well as elucidating compound(s) responsible for these activities. A collection of 191 actinomycete isolates were recovered from five types of manure composts collected around Selangor, Malaysia. The highest recovery was observed on SCNA medium at 30ºC. The combination of micromorphological characteristics and 16S rRNA sequence analysis revealed considerable actinomycete diversity which covers 12 genera within nine families… Institute of Graduate Studies, UiTM 2016 Book Section PeerReviewed text en http://ir.uitm.edu.my/id/eprint/19902/1/ABS_ANIS%20LOW%20MUHAMMAD%20LOW%20TDRA%20VOL%2010%20IGS%2016.pdf Muhammad Low, Anis Low (2016) Antimicrobial activities and enhancers of DNA gyrase inhibitors from manure compost actinomycetes / Anis Low Muhammad Low. In: The Doctoral Research Abstracts. IGS Biannual Publication, 10 (10). Institute of Graduate Studies, UiTM, Shah Alam.
repository_type Digital Repository
institution_category Local University
institution Universiti Teknologi MARA
building UiTM Institutional Repository
collection Online Access
language English
topic Malaysia
spellingShingle Malaysia
Muhammad Low, Anis Low
Antimicrobial activities and enhancers of DNA gyrase inhibitors from manure compost actinomycetes / Anis Low Muhammad Low
description Actinomycetes are invaluable sources of bioactive microbial compounds and have been the central of novel drug research as they continuously contribute to the pharmaceutical industry. The traditional perception of actinomycetes being soil bound has currently changed with evidence demonstrating their colonization in unique microenvironment. Through evolution and environmental adaptation, development of unusual metabolic activities has resulted in a variety of anti-infective agents from these bacteria. Nevertheless, the discovery of actinomycetes and its bioactive secondary metabolites from manure compost materials remained understudied. This research was therefore undertaken with the aim of isolating and characterizing the diversity of actinomycetes from manure composts, identifying morphologically distinct isolates, screening isolates for potential antimicrobial activities and bioactive compounds which act as enhancers for DNA gyrase inhibitor as well as elucidating compound(s) responsible for these activities. A collection of 191 actinomycete isolates were recovered from five types of manure composts collected around Selangor, Malaysia. The highest recovery was observed on SCNA medium at 30ºC. The combination of micromorphological characteristics and 16S rRNA sequence analysis revealed considerable actinomycete diversity which covers 12 genera within nine families…
format Book Section
author Muhammad Low, Anis Low
author_facet Muhammad Low, Anis Low
author_sort Muhammad Low, Anis Low
title Antimicrobial activities and enhancers of DNA gyrase inhibitors from manure compost actinomycetes / Anis Low Muhammad Low
title_short Antimicrobial activities and enhancers of DNA gyrase inhibitors from manure compost actinomycetes / Anis Low Muhammad Low
title_full Antimicrobial activities and enhancers of DNA gyrase inhibitors from manure compost actinomycetes / Anis Low Muhammad Low
title_fullStr Antimicrobial activities and enhancers of DNA gyrase inhibitors from manure compost actinomycetes / Anis Low Muhammad Low
title_full_unstemmed Antimicrobial activities and enhancers of DNA gyrase inhibitors from manure compost actinomycetes / Anis Low Muhammad Low
title_sort antimicrobial activities and enhancers of dna gyrase inhibitors from manure compost actinomycetes / anis low muhammad low
publisher Institute of Graduate Studies, UiTM
publishDate 2016
url http://ir.uitm.edu.my/id/eprint/19902/
http://ir.uitm.edu.my/id/eprint/19902/1/ABS_ANIS%20LOW%20MUHAMMAD%20LOW%20TDRA%20VOL%2010%20IGS%2016.pdf
first_indexed 2023-09-18T23:03:32Z
last_indexed 2023-09-18T23:03:32Z
_version_ 1777418331746205696

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