Cytological and molecular analysis of anti-tumour bioactivities of Urgines maritima (L.) baker aqueous extract on human malignant neuroblastoma with its neuroprotection ability / Maati Musbah Saleh Elghuol

This study was conducted with the hypothesis that the phytochemical closely related to Libyan medicinal herb, Urginea maritima (L.) Baker constituents within water-based extract would own appropriately powerful properties that contribute to intrinsic regulation specific antitumour activities in...

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Main Author: Saleh Elghuol, Maati Musbah
Format: Book Section
Language:English
Published: Institute of Graduate Studies 2017
Subjects:
Online Access:http://ir.uitm.edu.my/id/eprint/18922/
http://ir.uitm.edu.my/id/eprint/18922/1/ABS_MAATI%20MUSBAH%20SALEH%20ELGHUOL%20TDRA%20VOL%2012%20IGS%2017.pdf
id uitm-18922
recordtype eprints
spelling uitm-189222018-01-25T08:58:11Z http://ir.uitm.edu.my/id/eprint/18922/ Cytological and molecular analysis of anti-tumour bioactivities of Urgines maritima (L.) baker aqueous extract on human malignant neuroblastoma with its neuroprotection ability / Maati Musbah Saleh Elghuol Saleh Elghuol, Maati Musbah QM Human anatomy Cancer This study was conducted with the hypothesis that the phytochemical closely related to Libyan medicinal herb, Urginea maritima (L.) Baker constituents within water-based extract would own appropriately powerful properties that contribute to intrinsic regulation specific antitumour activities in human malignant SH-SY5Y neuroblastoma cells. The purpose of the present study was to explore the characterisation and identification of the major phytochemical of the U. maritima aqueous extract. Additionally, the study also aimed to evaluate their effectiveness on the cellular and molecular mechanism associated with the main anti-tumour criteria. Through utilising several in-vitro techniques on both the experimental cell line models involving (2× 104 to 1× 106 cells/ml) with the quality of ≥ 90% viability of SH-SY5Y neuroblastoma and RA differentiated (neuronmodel) cells. Evaluation of the impact of the active extract ingredients was conducted based on morphological observation, biochemical, cellular function and gene expression profile, and the analysis was carried out for its estimation within different concentrations and durations. Neuroblastoma is a well-known extra-cranial solid tumour and one of the most deadly malignancies in childhood. Institute of Graduate Studies 2017 Book Section PeerReviewed text en http://ir.uitm.edu.my/id/eprint/18922/1/ABS_MAATI%20MUSBAH%20SALEH%20ELGHUOL%20TDRA%20VOL%2012%20IGS%2017.pdf Saleh Elghuol, Maati Musbah (2017) Cytological and molecular analysis of anti-tumour bioactivities of Urgines maritima (L.) baker aqueous extract on human malignant neuroblastoma with its neuroprotection ability / Maati Musbah Saleh Elghuol. In: The Doctoral Research Abstracts. IGS Biannual Publication, 12 (12). Institute of Graduate Studies, Shah Alam.
repository_type Digital Repository
institution_category Local University
institution Universiti Teknologi MARA
building UiTM Institutional Repository
collection Online Access
language English
topic QM Human anatomy
Cancer
spellingShingle QM Human anatomy
Cancer
Saleh Elghuol, Maati Musbah
Cytological and molecular analysis of anti-tumour bioactivities of Urgines maritima (L.) baker aqueous extract on human malignant neuroblastoma with its neuroprotection ability / Maati Musbah Saleh Elghuol
description This study was conducted with the hypothesis that the phytochemical closely related to Libyan medicinal herb, Urginea maritima (L.) Baker constituents within water-based extract would own appropriately powerful properties that contribute to intrinsic regulation specific antitumour activities in human malignant SH-SY5Y neuroblastoma cells. The purpose of the present study was to explore the characterisation and identification of the major phytochemical of the U. maritima aqueous extract. Additionally, the study also aimed to evaluate their effectiveness on the cellular and molecular mechanism associated with the main anti-tumour criteria. Through utilising several in-vitro techniques on both the experimental cell line models involving (2× 104 to 1× 106 cells/ml) with the quality of ≥ 90% viability of SH-SY5Y neuroblastoma and RA differentiated (neuronmodel) cells. Evaluation of the impact of the active extract ingredients was conducted based on morphological observation, biochemical, cellular function and gene expression profile, and the analysis was carried out for its estimation within different concentrations and durations. Neuroblastoma is a well-known extra-cranial solid tumour and one of the most deadly malignancies in childhood.
format Book Section
author Saleh Elghuol, Maati Musbah
author_facet Saleh Elghuol, Maati Musbah
author_sort Saleh Elghuol, Maati Musbah
title Cytological and molecular analysis of anti-tumour bioactivities of Urgines maritima (L.) baker aqueous extract on human malignant neuroblastoma with its neuroprotection ability / Maati Musbah Saleh Elghuol
title_short Cytological and molecular analysis of anti-tumour bioactivities of Urgines maritima (L.) baker aqueous extract on human malignant neuroblastoma with its neuroprotection ability / Maati Musbah Saleh Elghuol
title_full Cytological and molecular analysis of anti-tumour bioactivities of Urgines maritima (L.) baker aqueous extract on human malignant neuroblastoma with its neuroprotection ability / Maati Musbah Saleh Elghuol
title_fullStr Cytological and molecular analysis of anti-tumour bioactivities of Urgines maritima (L.) baker aqueous extract on human malignant neuroblastoma with its neuroprotection ability / Maati Musbah Saleh Elghuol
title_full_unstemmed Cytological and molecular analysis of anti-tumour bioactivities of Urgines maritima (L.) baker aqueous extract on human malignant neuroblastoma with its neuroprotection ability / Maati Musbah Saleh Elghuol
title_sort cytological and molecular analysis of anti-tumour bioactivities of urgines maritima (l.) baker aqueous extract on human malignant neuroblastoma with its neuroprotection ability / maati musbah saleh elghuol
publisher Institute of Graduate Studies
publishDate 2017
url http://ir.uitm.edu.my/id/eprint/18922/
http://ir.uitm.edu.my/id/eprint/18922/1/ABS_MAATI%20MUSBAH%20SALEH%20ELGHUOL%20TDRA%20VOL%2012%20IGS%2017.pdf
first_indexed 2023-09-18T23:01:29Z
last_indexed 2023-09-18T23:01:29Z
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