Epstein-barr virus and its association with breast cancer / Prof Madya Dr Hjh Zuridah Hj Hassan and Dr Zeenathul Nazariah Allauddin

Epstein-barr virus (EBV) is widely distributed with 90-95% of adults are seropositive. This virus is spread by intimate contact between susceptible persons and asymptomatic shedders. EBV can be the causative agent of some B and T cell lymphomas, Hodgkin disease, nasopharyngeal carcinoma and also as...

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Main Author:	Hassan, Zuridah
Format:	Research Reports
Language:	English
Published:	Research Management Institute (RMI) 2010
Online Access:	http://ir.uitm.edu.my/id/eprint/18734/ http://ir.uitm.edu.my/id/eprint/18734/1/LP_ZURIDAH%20HASSAN%20RMI%2010_5.pdf

id	uitm-18734
recordtype	eprints
spelling	uitm-187342018-07-05T02:16:19Z http://ir.uitm.edu.my/id/eprint/18734/ Epstein-barr virus and its association with breast cancer / Prof Madya Dr Hjh Zuridah Hj Hassan and Dr Zeenathul Nazariah Allauddin Hassan, Zuridah Epstein-barr virus (EBV) is widely distributed with 90-95% of adults are seropositive. This virus is spread by intimate contact between susceptible persons and asymptomatic shedders. EBV can be the causative agent of some B and T cell lymphomas, Hodgkin disease, nasopharyngeal carcinoma and also as one of the cofactor in the development of many types of carcinomas including breast cancer. The role of Epstein-barr virus (EBV) in breast cancer is not well documented and reports are very controversial. On the other hand, current belief holds that chromosomal deficiency and translocation, deletion, insertion and point mutation in the p53 tumor suppressor gene (p53 gene) which plays an important role in the regulation of cell growth, differentiation and DNA repair can play a role. Abnormal cell proliferation is thought to be induced by p53 gene deficiency. In human carcinogenesis, p53 mutations are reported in esophageal carcinoma with documented changes in protein expression. There is also evidence that mechanisms other than point mutation may result in p53 protein accumulation and inactivation in a subset of breast cancer. Epidemiologic studies have implicated several lifestyle risk factors: tobacco exposure, alcohol consumption, diet, obesity in esophageal carcinoma. However, the clinical significance and potential applications of these observations in breast cancer remains unclear. Research Management Institute (RMI) 2010 Research Reports NonPeerReviewed text en http://ir.uitm.edu.my/id/eprint/18734/1/LP_ZURIDAH%20HASSAN%20RMI%2010_5.pdf Hassan, Zuridah (2010) Epstein-barr virus and its association with breast cancer / Prof Madya Dr Hjh Zuridah Hj Hassan and Dr Zeenathul Nazariah Allauddin. [Research Reports] (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Teknologi MARA
building	UiTM Institutional Repository
collection	Online Access
language	English
description	Epstein-barr virus (EBV) is widely distributed with 90-95% of adults are seropositive. This virus is spread by intimate contact between susceptible persons and asymptomatic shedders. EBV can be the causative agent of some B and T cell lymphomas, Hodgkin disease, nasopharyngeal carcinoma and also as one of the cofactor in the development of many types of carcinomas including breast cancer. The role of Epstein-barr virus (EBV) in breast cancer is not well documented and reports are very controversial. On the other hand, current belief holds that chromosomal deficiency and translocation, deletion, insertion and point mutation in the p53 tumor suppressor gene (p53 gene) which plays an important role in the regulation of cell growth, differentiation and DNA repair can play a role. Abnormal cell proliferation is thought to be induced by p53 gene deficiency. In human carcinogenesis, p53 mutations are reported in esophageal carcinoma with documented changes in protein expression. There is also evidence that mechanisms other than point mutation may result in p53 protein accumulation and inactivation in a subset of breast cancer. Epidemiologic studies have implicated several lifestyle risk factors: tobacco exposure, alcohol consumption, diet, obesity in esophageal carcinoma. However, the clinical significance and potential applications of these observations in breast cancer remains unclear.
format	Research Reports
author	Hassan, Zuridah
spellingShingle	Hassan, Zuridah Epstein-barr virus and its association with breast cancer / Prof Madya Dr Hjh Zuridah Hj Hassan and Dr Zeenathul Nazariah Allauddin
author_facet	Hassan, Zuridah
author_sort	Hassan, Zuridah
title	Epstein-barr virus and its association with breast cancer / Prof Madya Dr Hjh Zuridah Hj Hassan and Dr Zeenathul Nazariah Allauddin
title_short	Epstein-barr virus and its association with breast cancer / Prof Madya Dr Hjh Zuridah Hj Hassan and Dr Zeenathul Nazariah Allauddin
title_full	Epstein-barr virus and its association with breast cancer / Prof Madya Dr Hjh Zuridah Hj Hassan and Dr Zeenathul Nazariah Allauddin
title_fullStr	Epstein-barr virus and its association with breast cancer / Prof Madya Dr Hjh Zuridah Hj Hassan and Dr Zeenathul Nazariah Allauddin
title_full_unstemmed	Epstein-barr virus and its association with breast cancer / Prof Madya Dr Hjh Zuridah Hj Hassan and Dr Zeenathul Nazariah Allauddin
title_sort	epstein-barr virus and its association with breast cancer / prof madya dr hjh zuridah hj hassan and dr zeenathul nazariah allauddin
publisher	Research Management Institute (RMI)
publishDate	2010
url	http://ir.uitm.edu.my/id/eprint/18734/ http://ir.uitm.edu.my/id/eprint/18734/1/LP_ZURIDAH%20HASSAN%20RMI%2010_5.pdf
first_indexed	2023-09-18T23:01:06Z
last_indexed	2023-09-18T23:01:06Z
_version_	1777418179173154816

Epstein-barr virus and its association with breast cancer / Prof Madya Dr Hjh Zuridah Hj Hassan and Dr Zeenathul Nazariah Allauddin

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