Apoptosis pathway of Gelam (Melaleuca cajupati) honey on human colorectal carcinoma (HCT116) / Dr. Wan Iryani Wan Ismail and Dr. Mizaton Hazizul Hassan

Honey has been used for medical purposes since a long time ago. It had antimicrobial, antiviral and antiparasitic activities, and showed anti-inflammatory, antioxidant and antimutagenic effects. Previous studies demonstrated that honey may have potential as an anticancer agent as well. However, stud...

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Main Authors:	Wan Ismail, Wan Iryani, Hazizul Hassan, Mizaton
Format:	Research Reports
Language:	English
Published:	Research Management Institute (RMI) 2013
Subjects:	Research. Experimentation
Online Access:	http://ir.uitm.edu.my/id/eprint/18668/ http://ir.uitm.edu.my/id/eprint/18668/1/LP_WAN%20IRYANI%20WAN%20ISMAIL%20RMI%2013_5.pdf

id	uitm-18668
recordtype	eprints
spelling	uitm-186682018-07-05T06:09:09Z http://ir.uitm.edu.my/id/eprint/18668/ Apoptosis pathway of Gelam (Melaleuca cajupati) honey on human colorectal carcinoma (HCT116) / Dr. Wan Iryani Wan Ismail and Dr. Mizaton Hazizul Hassan Wan Ismail, Wan Iryani Hazizul Hassan, Mizaton Research. Experimentation Honey has been used for medical purposes since a long time ago. It had antimicrobial, antiviral and antiparasitic activities, and showed anti-inflammatory, antioxidant and antimutagenic effects. Previous studies demonstrated that honey may have potential as an anticancer agent as well. However, study of honey as anticancer agent is still at infancy level particularly in Malaysia. Several type of Malaysian honey such as Gelam, Pineapple and Coconut honey may have potential as an anticancer agent. Gelam honey showed better antimicrobial, antioxidant and wound healing activities, and therapeutic value than other honey and natural products. This was due to the difference in their phenolic contents which has a direct correlation to the antioxidant activity of honey. Antioxidant activity prevents oxidation reactions of free radical such as hydroxyl radical in cancer cell lines. High activity of antioxidant may provide a better anticancer agent. Thus, the honey will be chosen for the first time to analyse the possible mechanism pathway, in particular apoptosis pathway of human breast cancer (MCF7) using Western blot analysis. Understanding the molecular basis of Gelam honey to act against the cancer cell lines may shed new light on these honeys as a new anticancer agent in the future. Research Management Institute (RMI) 2013 Research Reports NonPeerReviewed text en http://ir.uitm.edu.my/id/eprint/18668/1/LP_WAN%20IRYANI%20WAN%20ISMAIL%20RMI%2013_5.pdf Wan Ismail, Wan Iryani and Hazizul Hassan, Mizaton (2013) Apoptosis pathway of Gelam (Melaleuca cajupati) honey on human colorectal carcinoma (HCT116) / Dr. Wan Iryani Wan Ismail and Dr. Mizaton Hazizul Hassan. [Research Reports] (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Teknologi MARA
building	UiTM Institutional Repository
collection	Online Access
language	English
topic	Research. Experimentation
spellingShingle	Research. Experimentation Wan Ismail, Wan Iryani Hazizul Hassan, Mizaton Apoptosis pathway of Gelam (Melaleuca cajupati) honey on human colorectal carcinoma (HCT116) / Dr. Wan Iryani Wan Ismail and Dr. Mizaton Hazizul Hassan
description	Honey has been used for medical purposes since a long time ago. It had antimicrobial, antiviral and antiparasitic activities, and showed anti-inflammatory, antioxidant and antimutagenic effects. Previous studies demonstrated that honey may have potential as an anticancer agent as well. However, study of honey as anticancer agent is still at infancy level particularly in Malaysia. Several type of Malaysian honey such as Gelam, Pineapple and Coconut honey may have potential as an anticancer agent. Gelam honey showed better antimicrobial, antioxidant and wound healing activities, and therapeutic value than other honey and natural products. This was due to the difference in their phenolic contents which has a direct correlation to the antioxidant activity of honey. Antioxidant activity prevents oxidation reactions of free radical such as hydroxyl radical in cancer cell lines. High activity of antioxidant may provide a better anticancer agent. Thus, the honey will be chosen for the first time to analyse the possible mechanism pathway, in particular apoptosis pathway of human breast cancer (MCF7) using Western blot analysis. Understanding the molecular basis of Gelam honey to act against the cancer cell lines may shed new light on these honeys as a new anticancer agent in the future.
format	Research Reports
author	Wan Ismail, Wan Iryani Hazizul Hassan, Mizaton
author_facet	Wan Ismail, Wan Iryani Hazizul Hassan, Mizaton
author_sort	Wan Ismail, Wan Iryani
title	Apoptosis pathway of Gelam (Melaleuca cajupati) honey on human colorectal carcinoma (HCT116) / Dr. Wan Iryani Wan Ismail and Dr. Mizaton Hazizul Hassan
title_short	Apoptosis pathway of Gelam (Melaleuca cajupati) honey on human colorectal carcinoma (HCT116) / Dr. Wan Iryani Wan Ismail and Dr. Mizaton Hazizul Hassan
title_full	Apoptosis pathway of Gelam (Melaleuca cajupati) honey on human colorectal carcinoma (HCT116) / Dr. Wan Iryani Wan Ismail and Dr. Mizaton Hazizul Hassan
title_fullStr	Apoptosis pathway of Gelam (Melaleuca cajupati) honey on human colorectal carcinoma (HCT116) / Dr. Wan Iryani Wan Ismail and Dr. Mizaton Hazizul Hassan
title_full_unstemmed	Apoptosis pathway of Gelam (Melaleuca cajupati) honey on human colorectal carcinoma (HCT116) / Dr. Wan Iryani Wan Ismail and Dr. Mizaton Hazizul Hassan
title_sort	apoptosis pathway of gelam (melaleuca cajupati) honey on human colorectal carcinoma (hct116) / dr. wan iryani wan ismail and dr. mizaton hazizul hassan
publisher	Research Management Institute (RMI)
publishDate	2013
url	http://ir.uitm.edu.my/id/eprint/18668/ http://ir.uitm.edu.my/id/eprint/18668/1/LP_WAN%20IRYANI%20WAN%20ISMAIL%20RMI%2013_5.pdf
first_indexed	2023-09-18T23:01:03Z
last_indexed	2023-09-18T23:01:03Z
_version_	1777418175433932800

Apoptosis pathway of Gelam (Melaleuca cajupati) honey on human colorectal carcinoma (HCT116) / Dr. Wan Iryani Wan Ismail and Dr. Mizaton Hazizul Hassan

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