Antioxidant and anticancer activities of Pseuduvaria macrophylla / Atiqah Ab Aziz

Pseuduvaria macrophylla belongs to the Annonaceae family. This species has never been studied especially on their biological and chemical activities. In this study, antioxidant capacity by DPPH assay and ORAC assayJCso, TPC, compound analysis using mass spectrophotometry and cytotoxicity test agains...

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Main Author:	Ab Aziz, Atiqah
Format:	Thesis
Language:	English
Published:	2016
Online Access:	http://ir.uitm.edu.my/id/eprint/17846/ http://ir.uitm.edu.my/id/eprint/17846/2/TM_ATIQAH%20AB%20AZIZ%20AS%2016_5.pdf

id	uitm-17846
recordtype	eprints
spelling	uitm-178462018-10-10T02:33:23Z http://ir.uitm.edu.my/id/eprint/17846/ Antioxidant and anticancer activities of Pseuduvaria macrophylla / Atiqah Ab Aziz Ab Aziz, Atiqah Pseuduvaria macrophylla belongs to the Annonaceae family. This species has never been studied especially on their biological and chemical activities. In this study, antioxidant capacity by DPPH assay and ORAC assayJCso, TPC, compound analysis using mass spectrophotometry and cytotoxicity test against MCF-7, HT29 and PC-3 cancer cell of P. macrophylla bark and leaf crude extracts in methanol and hexane were evaluated. For antioxidant activity, the most active extract was bark methanolic extract with IC50 value of 31.9±0.1 M-g/mL (p<0.05). The methanolic crude extract of P. macrophylla inhibited the better proliferation of selected three cancer cell lines in the range (111.70 \|ug/ml±0.70 - 290.13 \|ug/ml±6.99) compared to hexane crude extracts. The major detected compounds were a-Cadinol, neophytadiene, palmitic acid, linoleic acid, methyl ester, oleic acid, isopolycerasodoil and isopolycerasodoil methyl ester. Obtained results from antioxidant assays, cytotoxicity test and chemical constituent analysis of P. macrophylla demonstrated promising antioxidant and anti cancer potentials 2016 Thesis NonPeerReviewed text en http://ir.uitm.edu.my/id/eprint/17846/2/TM_ATIQAH%20AB%20AZIZ%20AS%2016_5.pdf Ab Aziz, Atiqah (2016) Antioxidant and anticancer activities of Pseuduvaria macrophylla / Atiqah Ab Aziz. Masters thesis, Universiti Teknologi MARA.
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Teknologi MARA
building	UiTM Institutional Repository
collection	Online Access
language	English
description	Pseuduvaria macrophylla belongs to the Annonaceae family. This species has never been studied especially on their biological and chemical activities. In this study, antioxidant capacity by DPPH assay and ORAC assayJCso, TPC, compound analysis using mass spectrophotometry and cytotoxicity test against MCF-7, HT29 and PC-3 cancer cell of P. macrophylla bark and leaf crude extracts in methanol and hexane were evaluated. For antioxidant activity, the most active extract was bark methanolic extract with IC50 value of 31.9±0.1 M-g/mL (p<0.05). The methanolic crude extract of P. macrophylla inhibited the better proliferation of selected three cancer cell lines in the range (111.70 \|ug/ml±0.70 - 290.13 \|ug/ml±6.99) compared to hexane crude extracts. The major detected compounds were a-Cadinol, neophytadiene, palmitic acid, linoleic acid, methyl ester, oleic acid, isopolycerasodoil and isopolycerasodoil methyl ester. Obtained results from antioxidant assays, cytotoxicity test and chemical constituent analysis of P. macrophylla demonstrated promising antioxidant and anti cancer potentials
format	Thesis
author	Ab Aziz, Atiqah
spellingShingle	Ab Aziz, Atiqah Antioxidant and anticancer activities of Pseuduvaria macrophylla / Atiqah Ab Aziz
author_facet	Ab Aziz, Atiqah
author_sort	Ab Aziz, Atiqah
title	Antioxidant and anticancer activities of Pseuduvaria macrophylla / Atiqah Ab Aziz
title_short	Antioxidant and anticancer activities of Pseuduvaria macrophylla / Atiqah Ab Aziz
title_full	Antioxidant and anticancer activities of Pseuduvaria macrophylla / Atiqah Ab Aziz
title_fullStr	Antioxidant and anticancer activities of Pseuduvaria macrophylla / Atiqah Ab Aziz
title_full_unstemmed	Antioxidant and anticancer activities of Pseuduvaria macrophylla / Atiqah Ab Aziz
title_sort	antioxidant and anticancer activities of pseuduvaria macrophylla / atiqah ab aziz
publishDate	2016
url	http://ir.uitm.edu.my/id/eprint/17846/ http://ir.uitm.edu.my/id/eprint/17846/2/TM_ATIQAH%20AB%20AZIZ%20AS%2016_5.pdf
first_indexed	2023-09-18T22:59:12Z
last_indexed	2023-09-18T22:59:12Z
_version_	1777418058637246464

Antioxidant and anticancer activities of Pseuduvaria macrophylla / Atiqah Ab Aziz

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