Understanding the role of copy number (CNV) in the development of left ventricular hypertrophy in hypertension / Khalid Yusoff and Hoh Boon Peng

Left ventricular hypertrophy (LVH) is an independent risk factor for the development of heart failure, coronary heart disease and stroke. It develops as a result of hemodynamic overload, for instance, hypertension. Blood pressure is an important determinant of LVH, and a significant proportion of pa...

Full description

Bibliographic Details
Main Authors:	Yusoff, Khalid, Hoh, Boon Peng
Format:	Research Reports
Language:	English
Published:	Research Management Institute (RMI) 2012
Online Access:	http://ir.uitm.edu.my/id/eprint/17745/ http://ir.uitm.edu.my/id/eprint/17745/2/LP_KHALID%20YUSOFF%20RMI%2012_5.pdf

id	uitm-17745
recordtype	eprints
spelling	uitm-177452019-03-04T06:49:44Z http://ir.uitm.edu.my/id/eprint/17745/ Understanding the role of copy number (CNV) in the development of left ventricular hypertrophy in hypertension / Khalid Yusoff and Hoh Boon Peng Yusoff, Khalid Hoh, Boon Peng Left ventricular hypertrophy (LVH) is an independent risk factor for the development of heart failure, coronary heart disease and stroke. It develops as a result of hemodynamic overload, for instance, hypertension. Blood pressure is an important determinant of LVH, and a significant proportion of patients with essential hypertension develops this complication. However, this condition varies in a wide range of phenotypes, and studies had shown that patients with LVH may have near-normal blood pressure, suggesting that development of LVH may be due to an independent genetic factor from hypertension. LVH can be reversed with anti-hypertensive (anti-HT) agents. Angiotensinogen receptor blocker like losartan has been shown to improve the reversal effect. However, it is unknown whether using this anti-HT agent alone would be useful in preventing LVH. Hence, identifying HT patients with the risk of LVH may allow this hypothesis to be tested, and if successful, would lead to the prevention, treatment and improvement of prognosis of LVH. We recently carried out a genome-wide scan of copy number variation (CNV) on a group of hyptertensive LVH patients and observed a gain of copy number in AGTRII gene in a group of patients. We attempted to further investigate the role of CNV of this gene in the pathogenesis of LVH. However, we observed no significant contribution of this CNV in the disease complication. Therefore in this study, we attempted to investigate the contributions of rare CNV in the susceptibility of hypertensive LVH, and subsequently to predict the putative molecular pathways in the pathogenesis of LVH. Research Management Institute (RMI) 2012 Research Reports NonPeerReviewed text en http://ir.uitm.edu.my/id/eprint/17745/2/LP_KHALID%20YUSOFF%20RMI%2012_5.pdf Yusoff, Khalid and Hoh, Boon Peng (2012) Understanding the role of copy number (CNV) in the development of left ventricular hypertrophy in hypertension / Khalid Yusoff and Hoh Boon Peng. [Research Reports] (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Teknologi MARA
building	UiTM Institutional Repository
collection	Online Access
language	English
description	Left ventricular hypertrophy (LVH) is an independent risk factor for the development of heart failure, coronary heart disease and stroke. It develops as a result of hemodynamic overload, for instance, hypertension. Blood pressure is an important determinant of LVH, and a significant proportion of patients with essential hypertension develops this complication. However, this condition varies in a wide range of phenotypes, and studies had shown that patients with LVH may have near-normal blood pressure, suggesting that development of LVH may be due to an independent genetic factor from hypertension. LVH can be reversed with anti-hypertensive (anti-HT) agents. Angiotensinogen receptor blocker like losartan has been shown to improve the reversal effect. However, it is unknown whether using this anti-HT agent alone would be useful in preventing LVH. Hence, identifying HT patients with the risk of LVH may allow this hypothesis to be tested, and if successful, would lead to the prevention, treatment and improvement of prognosis of LVH. We recently carried out a genome-wide scan of copy number variation (CNV) on a group of hyptertensive LVH patients and observed a gain of copy number in AGTRII gene in a group of patients. We attempted to further investigate the role of CNV of this gene in the pathogenesis of LVH. However, we observed no significant contribution of this CNV in the disease complication. Therefore in this study, we attempted to investigate the contributions of rare CNV in the susceptibility of hypertensive LVH, and subsequently to predict the putative molecular pathways in the pathogenesis of LVH.
format	Research Reports
author	Yusoff, Khalid Hoh, Boon Peng
spellingShingle	Yusoff, Khalid Hoh, Boon Peng Understanding the role of copy number (CNV) in the development of left ventricular hypertrophy in hypertension / Khalid Yusoff and Hoh Boon Peng
author_facet	Yusoff, Khalid Hoh, Boon Peng
author_sort	Yusoff, Khalid
title	Understanding the role of copy number (CNV) in the development of left ventricular hypertrophy in hypertension / Khalid Yusoff and Hoh Boon Peng
title_short	Understanding the role of copy number (CNV) in the development of left ventricular hypertrophy in hypertension / Khalid Yusoff and Hoh Boon Peng
title_full	Understanding the role of copy number (CNV) in the development of left ventricular hypertrophy in hypertension / Khalid Yusoff and Hoh Boon Peng
title_fullStr	Understanding the role of copy number (CNV) in the development of left ventricular hypertrophy in hypertension / Khalid Yusoff and Hoh Boon Peng
title_full_unstemmed	Understanding the role of copy number (CNV) in the development of left ventricular hypertrophy in hypertension / Khalid Yusoff and Hoh Boon Peng
title_sort	understanding the role of copy number (cnv) in the development of left ventricular hypertrophy in hypertension / khalid yusoff and hoh boon peng
publisher	Research Management Institute (RMI)
publishDate	2012
url	http://ir.uitm.edu.my/id/eprint/17745/ http://ir.uitm.edu.my/id/eprint/17745/2/LP_KHALID%20YUSOFF%20RMI%2012_5.pdf
first_indexed	2023-09-18T22:58:58Z
last_indexed	2023-09-18T22:58:58Z
_version_	1777418044886220800

Understanding the role of copy number (CNV) in the development of left ventricular hypertrophy in hypertension / Khalid Yusoff and Hoh Boon Peng

Similar Items