Protective effect of Stevia Rebaudiana leaf extract on hemolytic behaviour of human erythrocyte in hydrogen peroxide-induced oxidative stress / Norhisham Haron … [et al.]

Stevia rebaudiana, a member of Asteraceae family is rich in stevioside and total phenolic compounds. The aim of the present study was to investigate the protective effect of Stevia rebaudiana leaf extract on human erythrocytes against oxidative damage, in vitro. The protective effect of Stevia rebau...

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Main Author:	Haron, Norhisham
Format:	Article
Language:	English
Published:	Universiti Teknologi MARA, Pulau Pinang & Pusat Penerbitan Universiti (UPENA) 2015
Online Access:	http://ir.uitm.edu.my/id/eprint/17019/ http://ir.uitm.edu.my/id/eprint/17019/2/AJ_NORHISHAM%20HARON%20ESTEEM%2015.pdf

id	uitm-17019
recordtype	eprints
spelling	uitm-170192019-08-09T02:10:39Z http://ir.uitm.edu.my/id/eprint/17019/ Protective effect of Stevia Rebaudiana leaf extract on hemolytic behaviour of human erythrocyte in hydrogen peroxide-induced oxidative stress / Norhisham Haron … [et al.] Haron, Norhisham Stevia rebaudiana, a member of Asteraceae family is rich in stevioside and total phenolic compounds. The aim of the present study was to investigate the protective effect of Stevia rebaudiana leaf extract on human erythrocytes against oxidative damage, in vitro. The protective effect of Stevia rebaudiana leaf extract in erythrocytes was studied in terms of resistance to hemolysis, lipid peroxidation and morphological changes. Stevia rebaudiana leaf extract at different concentrations (100, 200 and 300 μg/mL) was tested in 10 mM hydrogen peroxide (H₂O₂) induced oxidative stress on human erythrocytes. The hemolysis of erythrocytes induced by H₂O₂ was inhibited in a dose-dependent manner. The Stevia rebaudiana leaf extract was found to inhibit erythrocyte’s lipid peroxidation caused by H₂O₂. Morphological alterations in erythrocytes induced by H₂O₂ were protected by the leaf extract. In conclusion, the study demonstrated that Stevia rebaudiana leaf extract protected erythrocytes against oxidative damage due to its antioxidant properties. Universiti Teknologi MARA, Pulau Pinang & Pusat Penerbitan Universiti (UPENA) 2015 Article PeerReviewed text en http://ir.uitm.edu.my/id/eprint/17019/2/AJ_NORHISHAM%20HARON%20ESTEEM%2015.pdf Haron, Norhisham (2015) Protective effect of Stevia Rebaudiana leaf extract on hemolytic behaviour of human erythrocyte in hydrogen peroxide-induced oxidative stress / Norhisham Haron … [et al.]. Esteem Academic Journal : Engineering, Science & Technology, 11 (1). pp. 1-13. ISSN 1675-7939
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Teknologi MARA
building	UiTM Institutional Repository
collection	Online Access
language	English
description	Stevia rebaudiana, a member of Asteraceae family is rich in stevioside and total phenolic compounds. The aim of the present study was to investigate the protective effect of Stevia rebaudiana leaf extract on human erythrocytes against oxidative damage, in vitro. The protective effect of Stevia rebaudiana leaf extract in erythrocytes was studied in terms of resistance to hemolysis, lipid peroxidation and morphological changes. Stevia rebaudiana leaf extract at different concentrations (100, 200 and 300 μg/mL) was tested in 10 mM hydrogen peroxide (H₂O₂) induced oxidative stress on human erythrocytes. The hemolysis of erythrocytes induced by H₂O₂ was inhibited in a dose-dependent manner. The Stevia rebaudiana leaf extract was found to inhibit erythrocyte’s lipid peroxidation caused by H₂O₂. Morphological alterations in erythrocytes induced by H₂O₂ were protected by the leaf extract. In conclusion, the study demonstrated that Stevia rebaudiana leaf extract protected erythrocytes against oxidative damage due to its antioxidant properties.
format	Article
author	Haron, Norhisham
spellingShingle	Haron, Norhisham Protective effect of Stevia Rebaudiana leaf extract on hemolytic behaviour of human erythrocyte in hydrogen peroxide-induced oxidative stress / Norhisham Haron … [et al.]
author_facet	Haron, Norhisham
author_sort	Haron, Norhisham
title	Protective effect of Stevia Rebaudiana leaf extract on hemolytic behaviour of human erythrocyte in hydrogen peroxide-induced oxidative stress / Norhisham Haron … [et al.]
title_short	Protective effect of Stevia Rebaudiana leaf extract on hemolytic behaviour of human erythrocyte in hydrogen peroxide-induced oxidative stress / Norhisham Haron … [et al.]
title_full	Protective effect of Stevia Rebaudiana leaf extract on hemolytic behaviour of human erythrocyte in hydrogen peroxide-induced oxidative stress / Norhisham Haron … [et al.]
title_fullStr	Protective effect of Stevia Rebaudiana leaf extract on hemolytic behaviour of human erythrocyte in hydrogen peroxide-induced oxidative stress / Norhisham Haron … [et al.]
title_full_unstemmed	Protective effect of Stevia Rebaudiana leaf extract on hemolytic behaviour of human erythrocyte in hydrogen peroxide-induced oxidative stress / Norhisham Haron … [et al.]
title_sort	protective effect of stevia rebaudiana leaf extract on hemolytic behaviour of human erythrocyte in hydrogen peroxide-induced oxidative stress / norhisham haron … [et al.]
publisher	Universiti Teknologi MARA, Pulau Pinang & Pusat Penerbitan Universiti (UPENA)
publishDate	2015
url	http://ir.uitm.edu.my/id/eprint/17019/ http://ir.uitm.edu.my/id/eprint/17019/2/AJ_NORHISHAM%20HARON%20ESTEEM%2015.pdf
first_indexed	2023-09-18T22:57:22Z
last_indexed	2023-09-18T22:57:22Z
_version_	1777417944255430656

Protective effect of Stevia Rebaudiana leaf extract on hemolytic behaviour of human erythrocyte in hydrogen peroxide-induced oxidative stress / Norhisham Haron … [et al.]

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