Design of pectin-chitosan nanoparticles as oral insulin carrier / Syed Mohamad Al-Azi Syed Othman

Polymeric nanoparticles are characterized by high risks of premature drug dissolution and low drug encapsulation efficiency. The latter is aggravated by slow nanoparticle formation from large molecular weight polymers due to their slow diffusion kinetics in the reaction medium. This study investigat...

Full description

Bibliographic Details
Main Author:	Syed Othman, Syed Mohamad Al-Azi
Format:	Thesis
Language:	English
Published:	2015
Subjects:	Nanoparticles
Online Access:	http://ir.uitm.edu.my/id/eprint/15978/ http://ir.uitm.edu.my/id/eprint/15978/1/TM_SYED%20MOHAMAD%20AL-AZI%20SYED%20OTHMAN%20PH%2015_5.pdf

id	uitm-15978
recordtype	eprints
spelling	uitm-159782017-01-24T03:58:39Z http://ir.uitm.edu.my/id/eprint/15978/ Design of pectin-chitosan nanoparticles as oral insulin carrier / Syed Mohamad Al-Azi Syed Othman Syed Othman, Syed Mohamad Al-Azi Nanoparticles Polymeric nanoparticles are characterized by high risks of premature drug dissolution and low drug encapsulation efficiency. The latter is aggravated by slow nanoparticle formation from large molecular weight polymers due to their slow diffusion kinetics in the reaction medium. This study investigated large molecular weight pectin-chitosan coacervate in insulin encapsulation and sustained release. The nanoparticles were prepared through coacervation of pectin-insulin and chitosan with tripolyphosphate anions in pectin-insulin mixture, or calcium cations in chitosan solution. The formed particles were nanospray-dried when required. The size, zeta potential, morphology, drug content, drug association efficiency, drug release, polymer-polymer and drug-polymer interaction in particulate matrix were examined. Both non-crosslinked and crosslinked pectin-chitosan nanoparticles failed to encapsulate insulin substantially, unless nanoparticles were formed with rapid particle aggregation into micromatrices during coacervation. The aggregation level of nanoparticles can be reduced via spray drying and disaggregation of the particle clusters. These nanoparticles demonstrated fast drug release and chitosan dissolution. The chitosan dissolves readily in intestinal medium and can be utilised to increase mucosal permeability of the promptly released insulin in future endeavour. 2015 Thesis NonPeerReviewed text en http://ir.uitm.edu.my/id/eprint/15978/1/TM_SYED%20MOHAMAD%20AL-AZI%20SYED%20OTHMAN%20PH%2015_5.pdf Syed Othman, Syed Mohamad Al-Azi (2015) Design of pectin-chitosan nanoparticles as oral insulin carrier / Syed Mohamad Al-Azi Syed Othman. Masters thesis, Universiti Teknologi MARA.
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Teknologi MARA
building	UiTM Institutional Repository
collection	Online Access
language	English
topic	Nanoparticles
spellingShingle	Nanoparticles Syed Othman, Syed Mohamad Al-Azi Design of pectin-chitosan nanoparticles as oral insulin carrier / Syed Mohamad Al-Azi Syed Othman
description	Polymeric nanoparticles are characterized by high risks of premature drug dissolution and low drug encapsulation efficiency. The latter is aggravated by slow nanoparticle formation from large molecular weight polymers due to their slow diffusion kinetics in the reaction medium. This study investigated large molecular weight pectin-chitosan coacervate in insulin encapsulation and sustained release. The nanoparticles were prepared through coacervation of pectin-insulin and chitosan with tripolyphosphate anions in pectin-insulin mixture, or calcium cations in chitosan solution. The formed particles were nanospray-dried when required. The size, zeta potential, morphology, drug content, drug association efficiency, drug release, polymer-polymer and drug-polymer interaction in particulate matrix were examined. Both non-crosslinked and crosslinked pectin-chitosan nanoparticles failed to encapsulate insulin substantially, unless nanoparticles were formed with rapid particle aggregation into micromatrices during coacervation. The aggregation level of nanoparticles can be reduced via spray drying and disaggregation of the particle clusters. These nanoparticles demonstrated fast drug release and chitosan dissolution. The chitosan dissolves readily in intestinal medium and can be utilised to increase mucosal permeability of the promptly released insulin in future endeavour.
format	Thesis
author	Syed Othman, Syed Mohamad Al-Azi
author_facet	Syed Othman, Syed Mohamad Al-Azi
author_sort	Syed Othman, Syed Mohamad Al-Azi
title	Design of pectin-chitosan nanoparticles as oral insulin carrier / Syed Mohamad Al-Azi Syed Othman
title_short	Design of pectin-chitosan nanoparticles as oral insulin carrier / Syed Mohamad Al-Azi Syed Othman
title_full	Design of pectin-chitosan nanoparticles as oral insulin carrier / Syed Mohamad Al-Azi Syed Othman
title_fullStr	Design of pectin-chitosan nanoparticles as oral insulin carrier / Syed Mohamad Al-Azi Syed Othman
title_full_unstemmed	Design of pectin-chitosan nanoparticles as oral insulin carrier / Syed Mohamad Al-Azi Syed Othman
title_sort	design of pectin-chitosan nanoparticles as oral insulin carrier / syed mohamad al-azi syed othman
publishDate	2015
url	http://ir.uitm.edu.my/id/eprint/15978/ http://ir.uitm.edu.my/id/eprint/15978/1/TM_SYED%20MOHAMAD%20AL-AZI%20SYED%20OTHMAN%20PH%2015_5.pdf
first_indexed	2023-09-18T22:55:05Z
last_indexed	2023-09-18T22:55:05Z
_version_	1777417799892729856

Design of pectin-chitosan nanoparticles as oral insulin carrier / Syed Mohamad Al-Azi Syed Othman

Similar Items