Bioflavonoids from the leaves of ficus deltoidea jack with a-glucosidase inhibition / Nor Akmal Yati Sulong

The leaves of Ficus deltoidea are used as a traditional medicine by diabetes patients in Malaysia. The objective of the study is to identify and evaluate bioactive constituents with in vivo a-glucosidase inhibition. The partitioned extracts, subfractions and pure bioactive constituents were subjecte...

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Main Author:	Sulong, Nor Akmal Yati
Format:	Thesis
Language:	English
Published:	2014
Subjects:	Medical botany (General) Bioflavonoids. Vitamin P Herbs. Herbal teas
Online Access:	http://ir.uitm.edu.my/id/eprint/14099/ http://ir.uitm.edu.my/id/eprint/14099/1/TM_NOR%20AKMAL%20YATI%20SULONG%20PH%2014_5.pdf

id	uitm-14099
recordtype	eprints
spelling	uitm-140992016-06-21T02:52:45Z http://ir.uitm.edu.my/id/eprint/14099/ Bioflavonoids from the leaves of ficus deltoidea jack with a-glucosidase inhibition / Nor Akmal Yati Sulong Sulong, Nor Akmal Yati Medical botany (General) Bioflavonoids. Vitamin P Herbs. Herbal teas The leaves of Ficus deltoidea are used as a traditional medicine by diabetes patients in Malaysia. The objective of the study is to identify and evaluate bioactive constituents with in vivo a-glucosidase inhibition. The partitioned extracts, subfractions and pure bioactive constituents were subjected to the in vitro and in vivo a-glucosidase inhibition assay. The identified bioactive constituents were administered orally to sucrose loaded normoglycemic mice and induced diabetic rats. The postprandial blood glucose levels were monitored at 30 min interval. Acute toxicity was evaluated in both normoglycemic mice and induced diabetic rats. Bioactivity guided fractionation led to the isolation of C-glycosyl bioflavonoids namely,vitexin (78) and isovitexin (79). Oral administration of 1 mg/kg of either vitexin or isovitexin significantly (p<0.05) reduced the postprandial blood glucose level in sucrose loaded normoglycemic mice at 30 min. The percentage of postprandial blood glucose reduction was highest in sucrose loaded induced diabetic rats administered orally with 200 mg/kg of vitexin or 100 mg/kg of isovitexin. Both vitexin and isovitexin did not exert any signs of toxicity at the highest dose of 2 g/kg administered orally to normoglycemic mice and induced diabetic rats. Both the C-glycosyl bioflavonoids, namely, vitexin and isovitexin exhibited in vivo a-glucosidase inhibition. 2014 Thesis NonPeerReviewed text en http://ir.uitm.edu.my/id/eprint/14099/1/TM_NOR%20AKMAL%20YATI%20SULONG%20PH%2014_5.pdf Sulong, Nor Akmal Yati (2014) Bioflavonoids from the leaves of ficus deltoidea jack with a-glucosidase inhibition / Nor Akmal Yati Sulong. Masters thesis, Universiti Teknologi MARA.
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Teknologi MARA
building	UiTM Institutional Repository
collection	Online Access
language	English
topic	Medical botany (General) Bioflavonoids. Vitamin P Herbs. Herbal teas
spellingShingle	Medical botany (General) Bioflavonoids. Vitamin P Herbs. Herbal teas Sulong, Nor Akmal Yati Bioflavonoids from the leaves of ficus deltoidea jack with a-glucosidase inhibition / Nor Akmal Yati Sulong
description	The leaves of Ficus deltoidea are used as a traditional medicine by diabetes patients in Malaysia. The objective of the study is to identify and evaluate bioactive constituents with in vivo a-glucosidase inhibition. The partitioned extracts, subfractions and pure bioactive constituents were subjected to the in vitro and in vivo a-glucosidase inhibition assay. The identified bioactive constituents were administered orally to sucrose loaded normoglycemic mice and induced diabetic rats. The postprandial blood glucose levels were monitored at 30 min interval. Acute toxicity was evaluated in both normoglycemic mice and induced diabetic rats. Bioactivity guided fractionation led to the isolation of C-glycosyl bioflavonoids namely,vitexin (78) and isovitexin (79). Oral administration of 1 mg/kg of either vitexin or isovitexin significantly (p<0.05) reduced the postprandial blood glucose level in sucrose loaded normoglycemic mice at 30 min. The percentage of postprandial blood glucose reduction was highest in sucrose loaded induced diabetic rats administered orally with 200 mg/kg of vitexin or 100 mg/kg of isovitexin. Both vitexin and isovitexin did not exert any signs of toxicity at the highest dose of 2 g/kg administered orally to normoglycemic mice and induced diabetic rats. Both the C-glycosyl bioflavonoids, namely, vitexin and isovitexin exhibited in vivo a-glucosidase inhibition.
format	Thesis
author	Sulong, Nor Akmal Yati
author_facet	Sulong, Nor Akmal Yati
author_sort	Sulong, Nor Akmal Yati
title	Bioflavonoids from the leaves of ficus deltoidea jack with a-glucosidase inhibition / Nor Akmal Yati Sulong
title_short	Bioflavonoids from the leaves of ficus deltoidea jack with a-glucosidase inhibition / Nor Akmal Yati Sulong
title_full	Bioflavonoids from the leaves of ficus deltoidea jack with a-glucosidase inhibition / Nor Akmal Yati Sulong
title_fullStr	Bioflavonoids from the leaves of ficus deltoidea jack with a-glucosidase inhibition / Nor Akmal Yati Sulong
title_full_unstemmed	Bioflavonoids from the leaves of ficus deltoidea jack with a-glucosidase inhibition / Nor Akmal Yati Sulong
title_sort	bioflavonoids from the leaves of ficus deltoidea jack with a-glucosidase inhibition / nor akmal yati sulong
publishDate	2014
url	http://ir.uitm.edu.my/id/eprint/14099/ http://ir.uitm.edu.my/id/eprint/14099/1/TM_NOR%20AKMAL%20YATI%20SULONG%20PH%2014_5.pdf
first_indexed	2023-09-18T22:50:52Z
last_indexed	2023-09-18T22:50:52Z
_version_	1777417534806425600

Bioflavonoids from the leaves of ficus deltoidea jack with a-glucosidase inhibition / Nor Akmal Yati Sulong

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