Neurotoxicity and neuroprotective effects of Polyimides (PI) and Polyphenylenevinylene (PPV) against Hydrogen Peroxide (H2O2) / Norfaezah Mazalan ... [et al.]

Recently, research and development in the field of drug delivery systems (DDS) facilitating site-specific therapy has reached significant progression. DDS based on polymer micelles, coated micro- and nanoparticles, and various prodrug systems including water-soluble polymer have been prepared and ex...

Full description

Bibliographic Details
Main Authors:	Mazalan, Norfaezah, Mat Zain, Mazatulikhma, Jumali, Nor Saliyana, Mohalid, Norhanim, Shameri, Zurina, Hamzah, Ahmad Sazali
Format:	Article
Language:	English
Published:	Research Management Institute (RMI) 2011
Subjects:	Hydrogen peroxide Neuroprotective agents Neurotoxicology Polyimides
Online Access:	http://ir.uitm.edu.my/id/eprint/12948/ http://ir.uitm.edu.my/id/eprint/12948/1/AJ_NORFAEZAH%20MAZALAN%20SRJ%2011%201.pdf

id	uitm-12948
recordtype	eprints
spelling	uitm-129482016-05-30T02:41:00Z http://ir.uitm.edu.my/id/eprint/12948/ Neurotoxicity and neuroprotective effects of Polyimides (PI) and Polyphenylenevinylene (PPV) against Hydrogen Peroxide (H2O2) / Norfaezah Mazalan ... [et al.] Mazalan, Norfaezah Mat Zain, Mazatulikhma Jumali, Nor Saliyana Mohalid, Norhanim Shameri, Zurina Hamzah, Ahmad Sazali Hydrogen peroxide Neuroprotective agents Neurotoxicology Polyimides Recently, research and development in the field of drug delivery systems (DDS) facilitating site-specific therapy has reached significant progression. DDS based on polymer micelles, coated micro- and nanoparticles, and various prodrug systems including water-soluble polymer have been prepared and extensively studied as novel drugs designed for cancer chemotherapy and brain delivery. Since polymers are going to be used in human, this study has the interest of testing two types of polymer, polyimides (PI) and polyphenylenevinylene (PPV) on neuronal cells. The objective of this study was to determine the possible neurotoxicity and potential neuroprotective effects of PI and PPV towards SH-SY5Y neuronal cells challenged by hydrogen peroxide (H2O2) as an oxidant. Cells were pretreated with either PI or PPV for 1 hour followed by incubation for 24 hour with 100 μM of H2O2. MTS assay was used to assess cell viability. Results show that PI and PPV are not harmful within the concentration up to 10 μM and 100 μM, respectively. However, PI and PPV do not protect neuronal cells against toxicity induced by H2O2 or further up the cell death. Research Management Institute (RMI) 2011 Article PeerReviewed text en http://ir.uitm.edu.my/id/eprint/12948/1/AJ_NORFAEZAH%20MAZALAN%20SRJ%2011%201.pdf Mazalan, Norfaezah and Mat Zain, Mazatulikhma and Jumali, Nor Saliyana and Mohalid, Norhanim and Shameri, Zurina and Hamzah, Ahmad Sazali (2011) Neurotoxicity and neuroprotective effects of Polyimides (PI) and Polyphenylenevinylene (PPV) against Hydrogen Peroxide (H2O2) / Norfaezah Mazalan ... [et al.]. Scientific Research Journal, 8 (2). pp. 33-47. ISSN 1675-7009
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Teknologi MARA
building	UiTM Institutional Repository
collection	Online Access
language	English
topic	Hydrogen peroxide Neuroprotective agents Neurotoxicology Polyimides
spellingShingle	Hydrogen peroxide Neuroprotective agents Neurotoxicology Polyimides Mazalan, Norfaezah Mat Zain, Mazatulikhma Jumali, Nor Saliyana Mohalid, Norhanim Shameri, Zurina Hamzah, Ahmad Sazali Neurotoxicity and neuroprotective effects of Polyimides (PI) and Polyphenylenevinylene (PPV) against Hydrogen Peroxide (H2O2) / Norfaezah Mazalan ... [et al.]
description	Recently, research and development in the field of drug delivery systems (DDS) facilitating site-specific therapy has reached significant progression. DDS based on polymer micelles, coated micro- and nanoparticles, and various prodrug systems including water-soluble polymer have been prepared and extensively studied as novel drugs designed for cancer chemotherapy and brain delivery. Since polymers are going to be used in human, this study has the interest of testing two types of polymer, polyimides (PI) and polyphenylenevinylene (PPV) on neuronal cells. The objective of this study was to determine the possible neurotoxicity and potential neuroprotective effects of PI and PPV towards SH-SY5Y neuronal cells challenged by hydrogen peroxide (H2O2) as an oxidant. Cells were pretreated with either PI or PPV for 1 hour followed by incubation for 24 hour with 100 μM of H2O2. MTS assay was used to assess cell viability. Results show that PI and PPV are not harmful within the concentration up to 10 μM and 100 μM, respectively. However, PI and PPV do not protect neuronal cells against toxicity induced by H2O2 or further up the cell death.
format	Article
author	Mazalan, Norfaezah Mat Zain, Mazatulikhma Jumali, Nor Saliyana Mohalid, Norhanim Shameri, Zurina Hamzah, Ahmad Sazali
author_facet	Mazalan, Norfaezah Mat Zain, Mazatulikhma Jumali, Nor Saliyana Mohalid, Norhanim Shameri, Zurina Hamzah, Ahmad Sazali
author_sort	Mazalan, Norfaezah
title	Neurotoxicity and neuroprotective effects of Polyimides (PI) and Polyphenylenevinylene (PPV) against Hydrogen Peroxide (H2O2) / Norfaezah Mazalan ... [et al.]
title_short	Neurotoxicity and neuroprotective effects of Polyimides (PI) and Polyphenylenevinylene (PPV) against Hydrogen Peroxide (H2O2) / Norfaezah Mazalan ... [et al.]
title_full	Neurotoxicity and neuroprotective effects of Polyimides (PI) and Polyphenylenevinylene (PPV) against Hydrogen Peroxide (H2O2) / Norfaezah Mazalan ... [et al.]
title_fullStr	Neurotoxicity and neuroprotective effects of Polyimides (PI) and Polyphenylenevinylene (PPV) against Hydrogen Peroxide (H2O2) / Norfaezah Mazalan ... [et al.]
title_full_unstemmed	Neurotoxicity and neuroprotective effects of Polyimides (PI) and Polyphenylenevinylene (PPV) against Hydrogen Peroxide (H2O2) / Norfaezah Mazalan ... [et al.]
title_sort	neurotoxicity and neuroprotective effects of polyimides (pi) and polyphenylenevinylene (ppv) against hydrogen peroxide (h2o2) / norfaezah mazalan ... [et al.]
publisher	Research Management Institute (RMI)
publishDate	2011
url	http://ir.uitm.edu.my/id/eprint/12948/ http://ir.uitm.edu.my/id/eprint/12948/1/AJ_NORFAEZAH%20MAZALAN%20SRJ%2011%201.pdf
first_indexed	2023-09-18T22:49:36Z
last_indexed	2023-09-18T22:49:36Z
_version_	1777417455441805312

Neurotoxicity and neuroprotective effects of Polyimides (PI) and Polyphenylenevinylene (PPV) against Hydrogen Peroxide (H2O2) / Norfaezah Mazalan ... [et al.]

Similar Items