Lipase catalyzed betulinic acid derivatives and its cytotoxic activity / Yamin Yasin and Faujan Ahmad

Lipase catalyzed betulinic acid derivatives and its cytotoxic activity / Yamin Yasin and Faujan Ahmad

Betulinic acid, a triterpenoid found in many plant species, has attracted attention due to its important pharmacological properties, such as anti-cancer and anti-HIV activities. In order to obtain derivatives potentially useful for detailed pharmacological studies, derivatives were synthesized throu...

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Main Author: Ahmad, Faujan
Format: Article
Language:English
Published: Research Management Institute (RMI) 2010
Subjects:
Enzymes
Online Access:http://ir.uitm.edu.my/id/eprint/12932/
http://ir.uitm.edu.my/id/eprint/12932/1/AJ_YAMIN%20YASIN%20SRJ%2010%20%282%29.pdf
id uitm-12932
recordtype eprints
spelling uitm-129322019-03-28T02:45:20Z http://ir.uitm.edu.my/id/eprint/12932/ Lipase catalyzed betulinic acid derivatives and its cytotoxic activity / Yamin Yasin and Faujan Ahmad Ahmad, Faujan Enzymes Betulinic acid, a triterpenoid found in many plant species, has attracted attention due to its important pharmacological properties, such as anti-cancer and anti-HIV activities. In order to obtain derivatives potentially useful for detailed pharmacological studies, derivatives were synthesized through the reaction of betulinic acid with benzoyl chloride and acetic anhydride using a lipase catalyst. Enzyme-catalyzed reaction of betulinic acid with benzoyl chloride yielded 3B-benzoil-lup-20(29)-ene-28-oic acid ester (BCL), whereas the acetic anhydride reaction yielded 3B-acetoxy-lup-20(29)-ene-28-oic acid ester (BAA). The BAA underwent further reaction with l-decanol to produce 3B-acetoxy-lup-20(29)-ene-28 decanoate (BAAD). The prepared betulinic acid derivatives were tested for cytotoxic activity on three callcer cell lines in vitro: all tested compunds showed greater activity than betulinic acid. Research Management Institute (RMI) 2010 Article PeerReviewed text en http://ir.uitm.edu.my/id/eprint/12932/1/AJ_YAMIN%20YASIN%20SRJ%2010%20%282%29.pdf Ahmad, Faujan (2010) Lipase catalyzed betulinic acid derivatives and its cytotoxic activity / Yamin Yasin and Faujan Ahmad. Scientific Research Journal, 7 (1). pp. 65-76. ISSN 1675-7009
repository_type Digital Repository
institution_category Local University
institution Universiti Teknologi MARA
building UiTM Institutional Repository
collection Online Access
language English
topic Enzymes
spellingShingle Enzymes
Ahmad, Faujan
Lipase catalyzed betulinic acid derivatives and its cytotoxic activity / Yamin Yasin and Faujan Ahmad
description Betulinic acid, a triterpenoid found in many plant species, has attracted attention due to its important pharmacological properties, such as anti-cancer and anti-HIV activities. In order to obtain derivatives potentially useful for detailed pharmacological studies, derivatives were synthesized through the reaction of betulinic acid with benzoyl chloride and acetic anhydride using a lipase catalyst. Enzyme-catalyzed reaction of betulinic acid with benzoyl chloride yielded 3B-benzoil-lup-20(29)-ene-28-oic acid ester (BCL), whereas the acetic anhydride reaction yielded 3B-acetoxy-lup-20(29)-ene-28-oic acid ester (BAA). The BAA underwent further reaction with l-decanol to produce 3B-acetoxy-lup-20(29)-ene-28 decanoate (BAAD). The prepared betulinic acid derivatives were tested for cytotoxic activity on three callcer cell lines in vitro: all tested compunds showed greater activity than betulinic acid.
format Article
author Ahmad, Faujan
author_facet Ahmad, Faujan
author_sort Ahmad, Faujan
title Lipase catalyzed betulinic acid derivatives and its cytotoxic activity / Yamin Yasin and Faujan Ahmad
title_short Lipase catalyzed betulinic acid derivatives and its cytotoxic activity / Yamin Yasin and Faujan Ahmad
title_full Lipase catalyzed betulinic acid derivatives and its cytotoxic activity / Yamin Yasin and Faujan Ahmad
title_fullStr Lipase catalyzed betulinic acid derivatives and its cytotoxic activity / Yamin Yasin and Faujan Ahmad
title_full_unstemmed Lipase catalyzed betulinic acid derivatives and its cytotoxic activity / Yamin Yasin and Faujan Ahmad
title_sort lipase catalyzed betulinic acid derivatives and its cytotoxic activity / yamin yasin and faujan ahmad
publisher Research Management Institute (RMI)
publishDate 2010
url http://ir.uitm.edu.my/id/eprint/12932/
http://ir.uitm.edu.my/id/eprint/12932/1/AJ_YAMIN%20YASIN%20SRJ%2010%20%282%29.pdf
first_indexed 2023-09-18T22:49:34Z
last_indexed 2023-09-18T22:49:34Z
_version_ 1777417453569048576

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