The TDR Tuberculosis Specimen Bank : A Resource for Diagnostic Test Developers

BACKGROUND: The Special Programme for Research and Training in Tropical Diseases established a specimen bank in 1999 to support the development and evaluation of new tuberculosis (TB) diagnostic tools. OBJECTIVE: To provide a narrative of the bank's development and discuss lessons learned, the...

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Main Authors: Nathanson, C. M., Cuevas, L. E., Cunningham, J., Perkins, M. D., Peeling, R. W., Guillerm, M., Moussy, F., Ramsay, A.
Format: Journal Article
Language:EN
Published: 2012
Subjects:
Online Access:http://hdl.handle.net/10986/5114
id okr-10986-5114
recordtype oai_dc
spelling okr-10986-51142021-04-23T14:02:21Z The TDR Tuberculosis Specimen Bank : A Resource for Diagnostic Test Developers Nathanson, C. M. Cuevas, L. E. Cunningham, J. Perkins, M. D. Peeling, R. W. Guillerm, M. Moussy, F. Ramsay, A. Biological Specimen Banks Humans Specimen Handling Sputum Tropical Medicine Tuberculosis BACKGROUND: The Special Programme for Research and Training in Tropical Diseases established a specimen bank in 1999 to support the development and evaluation of new tuberculosis (TB) diagnostic tools. OBJECTIVE: To provide a narrative of the bank's development and discuss lessons learned, the bank's limitations and potential future applications. RESULTS: Collection sites were selected in high- and low-prevalence settings. Patients with TB symptoms, consenting to participate and to undergo human immunodeficiency virus testing were enrolled and diagnosed. Serum, sputum, saliva and urine samples were collected and sent to the bank's repositories. The bank has stocked 41,437 samples from 2524 patients at 11 sites worldwide. Ninety-five requests for specimens have been reviewed and 67 sets have been approved. Approved applicants have received sets of 20 or 200 samples. The bank allowed an evaluation of 19 commercial lateral flow tests and showed that none of them had broad global utility for TB diagnosis. CONCLUSIONS: The establishment and development of the specimen bank have provided a wealth of experience. It is fulfilling a need to provide quality specimens, but the type and number of samples may not fulfil the demands of future end-users. Plans are underway to review the mechanisms of specimen collection and distribution to maximise their impact on product development. 2012-03-30T07:31:21Z 2012-03-30T07:31:21Z 2010 Journal Article Int J Tuberc Lung Dis 1815-7920 (Electronic) 1027-3719 (Linking) http://hdl.handle.net/10986/5114 EN http://creativecommons.org/licenses/by-nc-nd/3.0/igo World Bank Journal Article
repository_type Digital Repository
institution_category Foreign Institution
institution Digital Repositories
building World Bank Open Knowledge Repository
collection World Bank
language EN
topic Biological Specimen Banks
Humans
Specimen Handling
Sputum
Tropical Medicine
Tuberculosis
spellingShingle Biological Specimen Banks
Humans
Specimen Handling
Sputum
Tropical Medicine
Tuberculosis
Nathanson, C. M.
Cuevas, L. E.
Cunningham, J.
Perkins, M. D.
Peeling, R. W.
Guillerm, M.
Moussy, F.
Ramsay, A.
The TDR Tuberculosis Specimen Bank : A Resource for Diagnostic Test Developers
relation http://creativecommons.org/licenses/by-nc-nd/3.0/igo
description BACKGROUND: The Special Programme for Research and Training in Tropical Diseases established a specimen bank in 1999 to support the development and evaluation of new tuberculosis (TB) diagnostic tools. OBJECTIVE: To provide a narrative of the bank's development and discuss lessons learned, the bank's limitations and potential future applications. RESULTS: Collection sites were selected in high- and low-prevalence settings. Patients with TB symptoms, consenting to participate and to undergo human immunodeficiency virus testing were enrolled and diagnosed. Serum, sputum, saliva and urine samples were collected and sent to the bank's repositories. The bank has stocked 41,437 samples from 2524 patients at 11 sites worldwide. Ninety-five requests for specimens have been reviewed and 67 sets have been approved. Approved applicants have received sets of 20 or 200 samples. The bank allowed an evaluation of 19 commercial lateral flow tests and showed that none of them had broad global utility for TB diagnosis. CONCLUSIONS: The establishment and development of the specimen bank have provided a wealth of experience. It is fulfilling a need to provide quality specimens, but the type and number of samples may not fulfil the demands of future end-users. Plans are underway to review the mechanisms of specimen collection and distribution to maximise their impact on product development.
format Journal Article
author Nathanson, C. M.
Cuevas, L. E.
Cunningham, J.
Perkins, M. D.
Peeling, R. W.
Guillerm, M.
Moussy, F.
Ramsay, A.
author_facet Nathanson, C. M.
Cuevas, L. E.
Cunningham, J.
Perkins, M. D.
Peeling, R. W.
Guillerm, M.
Moussy, F.
Ramsay, A.
author_sort Nathanson, C. M.
title The TDR Tuberculosis Specimen Bank : A Resource for Diagnostic Test Developers
title_short The TDR Tuberculosis Specimen Bank : A Resource for Diagnostic Test Developers
title_full The TDR Tuberculosis Specimen Bank : A Resource for Diagnostic Test Developers
title_fullStr The TDR Tuberculosis Specimen Bank : A Resource for Diagnostic Test Developers
title_full_unstemmed The TDR Tuberculosis Specimen Bank : A Resource for Diagnostic Test Developers
title_sort tdr tuberculosis specimen bank : a resource for diagnostic test developers
publishDate 2012
url http://hdl.handle.net/10986/5114
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