Lipid peroxidation in chronic cerebral hypoperfusion- induced neurodegeneration in rats

Introduction: Reduced cerebral blood fl ow is associated with neurodegenerative disorders and dementia, in particular. Experimental evidence has demonstrated the initiating role of chronic cerebral hypoperfusion in neuronal damage to the hippocampus, the cerebral cortex, the white matter areas and...

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Main Authors:	Saxena, Anil Kumar, Abdul Majeed, Saif Saad, Oothuman, Pakeer, Mustafa Mahmoud, Mohammed Imad Al-Deen
Format:	Article
Language:	English
Published:	Faculty of Medicine, International Islamic University Malaysia 2011
Subjects:	RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Online Access:	http://irep.iium.edu.my/9981/ http://irep.iium.edu.my/9981/ http://irep.iium.edu.my/9981/1/download.pdf

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recordtype	eprints
spelling	iium-99812013-04-11T03:17:38Z http://irep.iium.edu.my/9981/ Lipid peroxidation in chronic cerebral hypoperfusion- induced neurodegeneration in rats Saxena, Anil Kumar Abdul Majeed, Saif Saad Oothuman, Pakeer Mustafa Mahmoud, Mohammed Imad Al-Deen RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry Introduction: Reduced cerebral blood fl ow is associated with neurodegenerative disorders and dementia, in particular. Experimental evidence has demonstrated the initiating role of chronic cerebral hypoperfusion in neuronal damage to the hippocampus, the cerebral cortex, the white matter areas and the visual system. Permanent, bilateral occlusion of the common carotid arteries of rats (two vessel occlusion - 2VO) has been introduced for the reproduction of chronic cerebral hypoperfusion as it occurs in Alzheimer’s disease and human aging. Increased generation of free radicals through lipid peroxidation can damage neuronal cell membrane. Markers of lipid peroxidation have been found to be elevated in brain tissues and body fluids in neurodegenerative diseases, including Alzheimer’s disease, Parkinson disease and amyotrophic lateral sclerosis. Materials and Methods: Malondialdehyde (MDA), final product of lipid peroxidation, was estimated by thiobarbituric acid-reactive substances (TBARS) assay kit at eight weeks after induction of 2VO in the rats and control group. Results: Our study revealed a highly signifi cant (p<0.001) increase in the mean MDA concentration (12.296 ± 1.113 ìM) in 2VO rats as compared to the control group (5.286 ± 0.363 ìM) rats. Conclusion: Therapeutic strategies to modulate lipid peroxidation early throughout the course of the disease may be promising in slowing or possibly preventing neurodegenerative disorders. Faculty of Medicine, International Islamic University Malaysia 2011-12 Article PeerReviewed application/pdf en http://irep.iium.edu.my/9981/1/download.pdf Saxena, Anil Kumar and Abdul Majeed, Saif Saad and Oothuman, Pakeer and Mustafa Mahmoud, Mohammed Imad Al-Deen (2011) Lipid peroxidation in chronic cerebral hypoperfusion- induced neurodegeneration in rats. International Medical Journal Malaysia, 10 (2). pp. 3-6. ISSN 1823-4631 http://www.e-imj.com/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
spellingShingle	RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry Saxena, Anil Kumar Abdul Majeed, Saif Saad Oothuman, Pakeer Mustafa Mahmoud, Mohammed Imad Al-Deen Lipid peroxidation in chronic cerebral hypoperfusion- induced neurodegeneration in rats
description	Introduction: Reduced cerebral blood fl ow is associated with neurodegenerative disorders and dementia, in particular. Experimental evidence has demonstrated the initiating role of chronic cerebral hypoperfusion in neuronal damage to the hippocampus, the cerebral cortex, the white matter areas and the visual system. Permanent, bilateral occlusion of the common carotid arteries of rats (two vessel occlusion - 2VO) has been introduced for the reproduction of chronic cerebral hypoperfusion as it occurs in Alzheimer’s disease and human aging. Increased generation of free radicals through lipid peroxidation can damage neuronal cell membrane. Markers of lipid peroxidation have been found to be elevated in brain tissues and body fluids in neurodegenerative diseases, including Alzheimer’s disease, Parkinson disease and amyotrophic lateral sclerosis. Materials and Methods: Malondialdehyde (MDA), final product of lipid peroxidation, was estimated by thiobarbituric acid-reactive substances (TBARS) assay kit at eight weeks after induction of 2VO in the rats and control group. Results: Our study revealed a highly signifi cant (p<0.001) increase in the mean MDA concentration (12.296 ± 1.113 ìM) in 2VO rats as compared to the control group (5.286 ± 0.363 ìM) rats. Conclusion: Therapeutic strategies to modulate lipid peroxidation early throughout the course of the disease may be promising in slowing or possibly preventing neurodegenerative disorders.
format	Article
author	Saxena, Anil Kumar Abdul Majeed, Saif Saad Oothuman, Pakeer Mustafa Mahmoud, Mohammed Imad Al-Deen
author_facet	Saxena, Anil Kumar Abdul Majeed, Saif Saad Oothuman, Pakeer Mustafa Mahmoud, Mohammed Imad Al-Deen
author_sort	Saxena, Anil Kumar
title	Lipid peroxidation in chronic cerebral hypoperfusion- induced neurodegeneration in rats
title_short	Lipid peroxidation in chronic cerebral hypoperfusion- induced neurodegeneration in rats
title_full	Lipid peroxidation in chronic cerebral hypoperfusion- induced neurodegeneration in rats
title_fullStr	Lipid peroxidation in chronic cerebral hypoperfusion- induced neurodegeneration in rats
title_full_unstemmed	Lipid peroxidation in chronic cerebral hypoperfusion- induced neurodegeneration in rats
title_sort	lipid peroxidation in chronic cerebral hypoperfusion- induced neurodegeneration in rats
publisher	Faculty of Medicine, International Islamic University Malaysia
publishDate	2011
url	http://irep.iium.edu.my/9981/ http://irep.iium.edu.my/9981/ http://irep.iium.edu.my/9981/1/download.pdf
first_indexed	2023-09-18T20:19:44Z
last_indexed	2023-09-18T20:19:44Z
_version_	1777408025923944448

Lipid peroxidation in chronic cerebral hypoperfusion- induced neurodegeneration in rats

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