Palm-tocotrienol rich fraction has hypohomocysteinemic effect in rats fed high methionine diet

Palm-tocotrienol rich fraction has hypohomocysteinemic effect in rats fed high methionine diet

Hyperhomocysteinemia is associated with increased risk of cardiovascular disease (1). It is associated with elevation of oxidative stress (2). The aim of this study was to determine the effects of palm-tocotrienol rich fraction (TRF), a known anti-oxidant, at various doses on plasma total homocystei...

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Main Authors: Ku Zaifah, Norsidah, Yusuf, Kamisah, Yusuf, Ahmad Asmadi, Ayob, Azizi
Format: Conference or Workshop Item
Language:English
Published: 2011
Subjects:
RM214 Diet therapy. Diet and dietectics in disease
Online Access:http://irep.iium.edu.my/9966/
http://irep.iium.edu.my/9966/1/IIREE_12__Dr.Norsidah_Poster.ppt
id iium-9966
recordtype eprints
spelling iium-99662015-04-07T03:31:53Z http://irep.iium.edu.my/9966/ Palm-tocotrienol rich fraction has hypohomocysteinemic effect in rats fed high methionine diet Ku Zaifah, Norsidah Yusuf, Kamisah Yusuf, Ahmad Asmadi Ayob, Azizi RM214 Diet therapy. Diet and dietectics in disease Hyperhomocysteinemia is associated with increased risk of cardiovascular disease (1). It is associated with elevation of oxidative stress (2). The aim of this study was to determine the effects of palm-tocotrienol rich fraction (TRF), a known anti-oxidant, at various doses on plasma total homocysteine level (tHcy) and activity of hepatic cystathionine-β-synthase (CBS) in rats fed high methionine diet, as compared to folate. Forty-two male Wistar rats were divided into six groups. Group 1 was the control. Groups 2 to 6 were fed 1% methionine diet for 10 weeks. From week 6 onward, folate (8 mg/kg diet) or palm TRF (30, 60 or 150 mg/kg diet) were added into the diet of groups 3, 4, 5 and 6. Body weights were recorded weekly. The rats were then sacrificed and plasma tHcy at week 0, 5 and 10, and the activity of liver cystathionine-β-synthase were determined. Statistical Package for Social Sciences (SPSS) 11.5 was used. Data is presented as Mean ± SEM. P < 0.05 is considered significant. High methionine diet did not affect body weight. It raised plasma total homocysteine (tHcy) but was prevented by palm TRF at various doses, as well as folate. However, unlike folate, palm TRF significantly caused reduction of liver CBS activity. 2011-02 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/9966/1/IIREE_12__Dr.Norsidah_Poster.ppt Ku Zaifah, Norsidah and Yusuf, Kamisah and Yusuf, Ahmad Asmadi and Ayob, Azizi (2011) Palm-tocotrienol rich fraction has hypohomocysteinemic effect in rats fed high methionine diet. In: IIUM Research, Invention and Innovation Exhibition (IRIIE) 2011, 9-10 Feb 2011, Cultural Activity Centre (CAC) and KAED Gallery IIUM.
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
topic RM214 Diet therapy. Diet and dietectics in disease
spellingShingle RM214 Diet therapy. Diet and dietectics in disease
Ku Zaifah, Norsidah
Yusuf, Kamisah
Yusuf, Ahmad Asmadi
Ayob, Azizi
Palm-tocotrienol rich fraction has hypohomocysteinemic effect in rats fed high methionine diet
description Hyperhomocysteinemia is associated with increased risk of cardiovascular disease (1). It is associated with elevation of oxidative stress (2). The aim of this study was to determine the effects of palm-tocotrienol rich fraction (TRF), a known anti-oxidant, at various doses on plasma total homocysteine level (tHcy) and activity of hepatic cystathionine-β-synthase (CBS) in rats fed high methionine diet, as compared to folate. Forty-two male Wistar rats were divided into six groups. Group 1 was the control. Groups 2 to 6 were fed 1% methionine diet for 10 weeks. From week 6 onward, folate (8 mg/kg diet) or palm TRF (30, 60 or 150 mg/kg diet) were added into the diet of groups 3, 4, 5 and 6. Body weights were recorded weekly. The rats were then sacrificed and plasma tHcy at week 0, 5 and 10, and the activity of liver cystathionine-β-synthase were determined. Statistical Package for Social Sciences (SPSS) 11.5 was used. Data is presented as Mean ± SEM. P < 0.05 is considered significant. High methionine diet did not affect body weight. It raised plasma total homocysteine (tHcy) but was prevented by palm TRF at various doses, as well as folate. However, unlike folate, palm TRF significantly caused reduction of liver CBS activity.
format Conference or Workshop Item
author Ku Zaifah, Norsidah
Yusuf, Kamisah
Yusuf, Ahmad Asmadi
Ayob, Azizi
author_facet Ku Zaifah, Norsidah
Yusuf, Kamisah
Yusuf, Ahmad Asmadi
Ayob, Azizi
author_sort Ku Zaifah, Norsidah
title Palm-tocotrienol rich fraction has hypohomocysteinemic effect in rats fed high methionine diet
title_short Palm-tocotrienol rich fraction has hypohomocysteinemic effect in rats fed high methionine diet
title_full Palm-tocotrienol rich fraction has hypohomocysteinemic effect in rats fed high methionine diet
title_fullStr Palm-tocotrienol rich fraction has hypohomocysteinemic effect in rats fed high methionine diet
title_full_unstemmed Palm-tocotrienol rich fraction has hypohomocysteinemic effect in rats fed high methionine diet
title_sort palm-tocotrienol rich fraction has hypohomocysteinemic effect in rats fed high methionine diet
publishDate 2011
url http://irep.iium.edu.my/9966/
http://irep.iium.edu.my/9966/1/IIREE_12__Dr.Norsidah_Poster.ppt
first_indexed 2023-09-18T20:19:43Z
last_indexed 2023-09-18T20:19:43Z
_version_ 1777408025351421952

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