Potential bioactivities of -mangostin from garcinia malaccensis Hk.f

Guttiferae family is well-known to have a wide range of phytochemical constituents and bioactivities. A phytochemical investigation of Garcinia malaccensis lead isolation of -mangostin, -mangostin and a triterpenoid. α-Mangostin, a xanthone has a lot of health benefits. Many studies have been repo...

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Main Authors:	Bakhtiar, M. Taher, Darnis, Deny Susanti, Solachuddin Jauhari, Arief Ichwan, Ahmad Zohri, Farah Syahidah, Nakazibwe, Sauba
Format:	Conference or Workshop Item
Language:	English
Published:	2011
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/8796/ http://irep.iium.edu.my/8796/ http://irep.iium.edu.my/8796/1/IRIE11-Registration_form-M.Taher-Mangostin-2.pdf

id	iium-8796
recordtype	eprints
spelling	iium-87962014-12-09T01:30:29Z http://irep.iium.edu.my/8796/ Potential bioactivities of -mangostin from garcinia malaccensis Hk.f Bakhtiar, M. Taher Darnis, Deny Susanti Solachuddin Jauhari, Arief Ichwan Ahmad Zohri, Farah Syahidah Nakazibwe, Sauba RS Pharmacy and materia medica Guttiferae family is well-known to have a wide range of phytochemical constituents and bioactivities. A phytochemical investigation of Garcinia malaccensis lead isolation of -mangostin, -mangostin and a triterpenoid. α-Mangostin, a xanthone has a lot of health benefits. Many studies have been reported to investigate the biological activities of α-mangostin. The present study was carried out to evaluate the antimicrobial, antioxidant and anticancer activities of α-mangostin. Its structural determination was done based on its spectroscopic analysis. α-Mangostin was tested for antimicrobial sensitivity via disc diffusion method against 4 bacteria. Results showed that S. aureus culture formed a clear inhibition zone. The diameter of zone of inhibition observed was 8 mm and minimum inhibition concentration (MIC) value was 0.025 mg/mL and minimum bactericidal concentration (MBC) value was 0.1 mg/mL, indicated that α-mangostin is a bacteriostatic and bactericidal agent which correlates to presence of hydroxyl group in its structure. In antioxidant properties tests, dot-blot DPPH staining showed a positive antioxidant activity of α-mangostin. In FTC method, α-mangostin was proved to be a good lipid peroxidation inhibitor, whereas in DPPH free radical scavenging activity method, it has very weak scavenging effects on free radicals. In antiproliferative assay, -mangostin exhibited activity against K562 and showed different activity against HSC3 and H1299 cell lines. Against K562, it exerted the value of IC50 20 µg/mL. This study can form a foundation for future studies in investigating of biological activities of α-mangostin and developing the natural abundant in improving a healthy community. 2011-02 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/8796/1/IRIE11-Registration_form-M.Taher-Mangostin-2.pdf Bakhtiar, M. Taher and Darnis, Deny Susanti and Solachuddin Jauhari, Arief Ichwan and Ahmad Zohri, Farah Syahidah and Nakazibwe, Sauba (2011) Potential bioactivities of -mangostin from garcinia malaccensis Hk.f. In: IIUM Research, Invention and Innovation Exhibition (IRIIE) 2011, 9-10 February 2011, Cultural Activity Centre (CAC) and KAED Gallery IIUM. http://www.iium.edu.my/irie/11/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Bakhtiar, M. Taher Darnis, Deny Susanti Solachuddin Jauhari, Arief Ichwan Ahmad Zohri, Farah Syahidah Nakazibwe, Sauba Potential bioactivities of -mangostin from garcinia malaccensis Hk.f
description	Guttiferae family is well-known to have a wide range of phytochemical constituents and bioactivities. A phytochemical investigation of Garcinia malaccensis lead isolation of -mangostin, -mangostin and a triterpenoid. α-Mangostin, a xanthone has a lot of health benefits. Many studies have been reported to investigate the biological activities of α-mangostin. The present study was carried out to evaluate the antimicrobial, antioxidant and anticancer activities of α-mangostin. Its structural determination was done based on its spectroscopic analysis. α-Mangostin was tested for antimicrobial sensitivity via disc diffusion method against 4 bacteria. Results showed that S. aureus culture formed a clear inhibition zone. The diameter of zone of inhibition observed was 8 mm and minimum inhibition concentration (MIC) value was 0.025 mg/mL and minimum bactericidal concentration (MBC) value was 0.1 mg/mL, indicated that α-mangostin is a bacteriostatic and bactericidal agent which correlates to presence of hydroxyl group in its structure. In antioxidant properties tests, dot-blot DPPH staining showed a positive antioxidant activity of α-mangostin. In FTC method, α-mangostin was proved to be a good lipid peroxidation inhibitor, whereas in DPPH free radical scavenging activity method, it has very weak scavenging effects on free radicals. In antiproliferative assay, -mangostin exhibited activity against K562 and showed different activity against HSC3 and H1299 cell lines. Against K562, it exerted the value of IC50 20 µg/mL. This study can form a foundation for future studies in investigating of biological activities of α-mangostin and developing the natural abundant in improving a healthy community.
format	Conference or Workshop Item
author	Bakhtiar, M. Taher Darnis, Deny Susanti Solachuddin Jauhari, Arief Ichwan Ahmad Zohri, Farah Syahidah Nakazibwe, Sauba
author_facet	Bakhtiar, M. Taher Darnis, Deny Susanti Solachuddin Jauhari, Arief Ichwan Ahmad Zohri, Farah Syahidah Nakazibwe, Sauba
author_sort	Bakhtiar, M. Taher
title	Potential bioactivities of -mangostin from garcinia malaccensis Hk.f
title_short	Potential bioactivities of -mangostin from garcinia malaccensis Hk.f
title_full	Potential bioactivities of -mangostin from garcinia malaccensis Hk.f
title_fullStr	Potential bioactivities of -mangostin from garcinia malaccensis Hk.f
title_full_unstemmed	Potential bioactivities of -mangostin from garcinia malaccensis Hk.f
title_sort	potential bioactivities of -mangostin from garcinia malaccensis hk.f
publishDate	2011
url	http://irep.iium.edu.my/8796/ http://irep.iium.edu.my/8796/ http://irep.iium.edu.my/8796/1/IRIE11-Registration_form-M.Taher-Mangostin-2.pdf
first_indexed	2023-09-18T20:18:37Z
last_indexed	2023-09-18T20:18:37Z
_version_	1777407956410695680

Potential bioactivities of -mangostin from garcinia malaccensis Hk.f

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