Development of alpha mangostin-PLGA nanoparticles as an anticancer agent

α-Mangostin, a xanthone which was isolated from Garcinia malaccensis has been documented to exhibit anticancer effects against many cancerous cell lines. Due its high cytotoxicity, this study had attempted to encapsulate the α-mangostin into biodegradable PLGA copolymer using colloidal-extraction so...

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Main Authors:	Aimen, Abdo, Mohamed, Farahidah, Bakhtiar, M. Taher
Format:	Conference or Workshop Item
Language:	English English
Published:	2011
Subjects:	RM300 Drugs and their action
Online Access:	http://irep.iium.edu.my/8785/ http://irep.iium.edu.my/8785/1/Abstract_Dr._Taher-IHCI2011_8785.pdf http://irep.iium.edu.my/8785/3/mangosteen-IHCI_poster_after_correct_.pdf

id	iium-8785
recordtype	eprints
spelling	iium-87852014-12-09T01:13:41Z http://irep.iium.edu.my/8785/ Development of alpha mangostin-PLGA nanoparticles as an anticancer agent Aimen, Abdo Mohamed, Farahidah Bakhtiar, M. Taher RM300 Drugs and their action α-Mangostin, a xanthone which was isolated from Garcinia malaccensis has been documented to exhibit anticancer effects against many cancerous cell lines. Due its high cytotoxicity, this study had attempted to encapsulate the α-mangostin into biodegradable PLGA copolymer using colloidal-extraction solvent evaporation method. Different emulsification process had been investigated. The resultant nanoparticles were characterized for their size distribution and external morphology by laser diffractometry and scanning electron microscope (SEM), respectively. The concentration of entrapped α-Mangostin was determined by HPLC. Our data demonstrated that the encapsulation efficiency was affected by the type of emulsification process. The in vitro anti-cancer activity of α-Mangostin-PLGA nanoparticles was evaluated using lung cancer cell line (A549) and was compared to the free α-Mangostin. Our data revealed that the PLGA nanoparticles loaded with α-Mangostin showed lower cytotoxic effect compared to free α-Mangostin. To conclude, PLGA nanoparticles may be used as a promising micro-carrier system to deliver α-Mangostin for passive targeting to tumors. 2011-12-07 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/8785/1/Abstract_Dr._Taher-IHCI2011_8785.pdf application/pdf en http://irep.iium.edu.my/8785/3/mangosteen-IHCI_poster_after_correct_.pdf Aimen, Abdo and Mohamed, Farahidah and Bakhtiar, M. Taher (2011) Development of alpha mangostin-PLGA nanoparticles as an anticancer agent. In: International Health Conference IIUM (IHCI 2011), 7-8 December 2011, Vistana Hotel, Kuantan. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RM300 Drugs and their action
spellingShingle	RM300 Drugs and their action Aimen, Abdo Mohamed, Farahidah Bakhtiar, M. Taher Development of alpha mangostin-PLGA nanoparticles as an anticancer agent
description	α-Mangostin, a xanthone which was isolated from Garcinia malaccensis has been documented to exhibit anticancer effects against many cancerous cell lines. Due its high cytotoxicity, this study had attempted to encapsulate the α-mangostin into biodegradable PLGA copolymer using colloidal-extraction solvent evaporation method. Different emulsification process had been investigated. The resultant nanoparticles were characterized for their size distribution and external morphology by laser diffractometry and scanning electron microscope (SEM), respectively. The concentration of entrapped α-Mangostin was determined by HPLC. Our data demonstrated that the encapsulation efficiency was affected by the type of emulsification process. The in vitro anti-cancer activity of α-Mangostin-PLGA nanoparticles was evaluated using lung cancer cell line (A549) and was compared to the free α-Mangostin. Our data revealed that the PLGA nanoparticles loaded with α-Mangostin showed lower cytotoxic effect compared to free α-Mangostin. To conclude, PLGA nanoparticles may be used as a promising micro-carrier system to deliver α-Mangostin for passive targeting to tumors.
format	Conference or Workshop Item
author	Aimen, Abdo Mohamed, Farahidah Bakhtiar, M. Taher
author_facet	Aimen, Abdo Mohamed, Farahidah Bakhtiar, M. Taher
author_sort	Aimen, Abdo
title	Development of alpha mangostin-PLGA nanoparticles as an anticancer agent
title_short	Development of alpha mangostin-PLGA nanoparticles as an anticancer agent
title_full	Development of alpha mangostin-PLGA nanoparticles as an anticancer agent
title_fullStr	Development of alpha mangostin-PLGA nanoparticles as an anticancer agent
title_full_unstemmed	Development of alpha mangostin-PLGA nanoparticles as an anticancer agent
title_sort	development of alpha mangostin-plga nanoparticles as an anticancer agent
publishDate	2011
url	http://irep.iium.edu.my/8785/ http://irep.iium.edu.my/8785/1/Abstract_Dr._Taher-IHCI2011_8785.pdf http://irep.iium.edu.my/8785/3/mangosteen-IHCI_poster_after_correct_.pdf
first_indexed	2023-09-18T20:18:36Z
last_indexed	2023-09-18T20:18:36Z
_version_	1777407955546669056

Development of alpha mangostin-PLGA nanoparticles as an anticancer agent

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