Potentiation of testicular cytotoxicity by the alkyltransferase inhibitor O6 benzylguanine and the 5-fluorouracil/N-(2-chloroethyl)-N-nitrosourea molecular combination, B.4152
Alkylating agents are a group of compounds that have a cytotoxic effect due to their ability to form adducts with DNA. Cells possess the ability to repair this damage via an enzyme, O6-alkylguanine-DNA alkyltransferase (AGT). To study the effect of inhibiting this repair mechanism upon testicular cy...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
1996
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/8409/ http://irep.iium.edu.my/8409/ http://irep.iium.edu.my/8409/ http://irep.iium.edu.my/8409/1/Reprod_Tox_1996_Suzanah.pdf |