Co-expression of Leptin and Leptin Receptor in Adenocarcinoma of the Colon in Malay Population

Objectives: To assess the role of leptin in human colonic adenocarcinoma and to establish its expression in Malay population patients by using immunohistochemistry study. Methodology: Immunohistochemical study (IHC) using antibodies against leptin and its receptor was applied to assess the expressio...

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Main Authors:	Abdulrazzaq, Saad Mohammed, Harun, Norra, Al-Kubaisi, Muna Khaleel Dheyab
Format:	Article
Language:	English
Published:	2020
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/79503/ http://irep.iium.edu.my/79503/ http://irep.iium.edu.my/79503/1/IJIRMS%202020%20Coexpresion%20of%20leptin%20and%20leptin%20rceptor%20in%20Adenocarcinoma%20of%20the%20colon%20in%20Malay%20population%20%281%29.pdf

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spelling	iium-795032020-03-16T03:20:40Z http://irep.iium.edu.my/79503/ Co-expression of Leptin and Leptin Receptor in Adenocarcinoma of the Colon in Malay Population Abdulrazzaq, Saad Mohammed Harun, Norra Al-Kubaisi, Muna Khaleel Dheyab R Medicine (General) Objectives: To assess the role of leptin in human colonic adenocarcinoma and to establish its expression in Malay population patients by using immunohistochemistry study. Methodology: Immunohistochemical study (IHC) using antibodies against leptin and its receptor was applied to assess the expression of leptin and its receptor in 38 samples of adenocarcinoma of the colon among Malay population and compare this expression with that of the adjacent normal colon tissue. Results: All the 38 colon adenocarcinoma samples stained strongly (100%) for leptin and 36 out of 38 also stained strongly for leptin receptor (95%). The other 2 (5%) stained weak (1+). However, the whole specimens of the normal adjacent colon tissue stained weakly (1+) for both leptin and leptin receptor. The expression of both hormones in cancer and normal tissue is significantly different (p<0.01). There was significant co-expression of both hormones in colonic cancerous tissue. Conclusions: Leptin/leptin receptor system may have a tumorigenic effect on the colon tissue, most likely by an autocrine process. Inhibition of leptin/leptin receptor system might be helpful in the prevention and management of colon cancer. Keywords: Leptin, Leptin receptor, Expression, Adenocarcinoma, Colon, Malay 2020-02-21 Article PeerReviewed application/pdf en http://irep.iium.edu.my/79503/1/IJIRMS%202020%20Coexpresion%20of%20leptin%20and%20leptin%20rceptor%20in%20Adenocarcinoma%20of%20the%20colon%20in%20Malay%20population%20%281%29.pdf Abdulrazzaq, Saad Mohammed and Harun, Norra and Al-Kubaisi, Muna Khaleel Dheyab (2020) Co-expression of Leptin and Leptin Receptor in Adenocarcinoma of the Colon in Malay Population. International Journal of Innovative Research in Medical Science (IJIRMS), 5 (2). pp. 71-77. ISSN 2455-8737 https://ijirms.in/index.php/ijirms/article/view/849
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Abdulrazzaq, Saad Mohammed Harun, Norra Al-Kubaisi, Muna Khaleel Dheyab Co-expression of Leptin and Leptin Receptor in Adenocarcinoma of the Colon in Malay Population
description	Objectives: To assess the role of leptin in human colonic adenocarcinoma and to establish its expression in Malay population patients by using immunohistochemistry study. Methodology: Immunohistochemical study (IHC) using antibodies against leptin and its receptor was applied to assess the expression of leptin and its receptor in 38 samples of adenocarcinoma of the colon among Malay population and compare this expression with that of the adjacent normal colon tissue. Results: All the 38 colon adenocarcinoma samples stained strongly (100%) for leptin and 36 out of 38 also stained strongly for leptin receptor (95%). The other 2 (5%) stained weak (1+). However, the whole specimens of the normal adjacent colon tissue stained weakly (1+) for both leptin and leptin receptor. The expression of both hormones in cancer and normal tissue is significantly different (p<0.01). There was significant co-expression of both hormones in colonic cancerous tissue. Conclusions: Leptin/leptin receptor system may have a tumorigenic effect on the colon tissue, most likely by an autocrine process. Inhibition of leptin/leptin receptor system might be helpful in the prevention and management of colon cancer. Keywords: Leptin, Leptin receptor, Expression, Adenocarcinoma, Colon, Malay
format	Article
author	Abdulrazzaq, Saad Mohammed Harun, Norra Al-Kubaisi, Muna Khaleel Dheyab
author_facet	Abdulrazzaq, Saad Mohammed Harun, Norra Al-Kubaisi, Muna Khaleel Dheyab
author_sort	Abdulrazzaq, Saad Mohammed
title	Co-expression of Leptin and Leptin Receptor in Adenocarcinoma of the Colon in Malay Population
title_short	Co-expression of Leptin and Leptin Receptor in Adenocarcinoma of the Colon in Malay Population
title_full	Co-expression of Leptin and Leptin Receptor in Adenocarcinoma of the Colon in Malay Population
title_fullStr	Co-expression of Leptin and Leptin Receptor in Adenocarcinoma of the Colon in Malay Population
title_full_unstemmed	Co-expression of Leptin and Leptin Receptor in Adenocarcinoma of the Colon in Malay Population
title_sort	co-expression of leptin and leptin receptor in adenocarcinoma of the colon in malay population
publishDate	2020
url	http://irep.iium.edu.my/79503/ http://irep.iium.edu.my/79503/ http://irep.iium.edu.my/79503/1/IJIRMS%202020%20Coexpresion%20of%20leptin%20and%20leptin%20rceptor%20in%20Adenocarcinoma%20of%20the%20colon%20in%20Malay%20population%20%281%29.pdf
first_indexed	2023-09-18T21:51:32Z
last_indexed	2023-09-18T21:51:32Z
_version_	1777413802201972736

Co-expression of Leptin and Leptin Receptor in Adenocarcinoma of the Colon in Malay Population

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