The promise of zebrafish as a model of metabolic syndrome

Metabolic syndrome is a cluster including hyperglycaemia, obesity, hypertension, and hypertriglyceridaemia as a result of biochemical and physiological alterations and can increase the risk of cardiovascular disease and diabetes. Fundamental research on this disease requires validated animal models....

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Main Authors:	Benchoula, Khaled, Khatib, Alfi, Jaffar, Ashika, Ahmed, Qamar Uddin, Wan Sulaiman, Wan Mohd. Azizi, Abdul Wahab, Ridhwan, El-Seedi, Hesham
Format:	Article
Language:	English English
Published:	International Press Editing Centre Incorporation 2019
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/79119/ http://irep.iium.edu.my/79119/ http://irep.iium.edu.my/79119/ http://irep.iium.edu.my/79119/1/benchoula%20et%20al%202019-EA.pdf http://irep.iium.edu.my/79119/7/Scopus%20-%20promise%20of%20zebrafish.pdf

id	iium-79119
recordtype	eprints
spelling	iium-791192020-02-26T04:37:06Z http://irep.iium.edu.my/79119/ The promise of zebrafish as a model of metabolic syndrome Benchoula, Khaled Khatib, Alfi Jaffar, Ashika Ahmed, Qamar Uddin Wan Sulaiman, Wan Mohd. Azizi Abdul Wahab, Ridhwan El-Seedi, Hesham R Medicine (General) Metabolic syndrome is a cluster including hyperglycaemia, obesity, hypertension, and hypertriglyceridaemia as a result of biochemical and physiological alterations and can increase the risk of cardiovascular disease and diabetes. Fundamental research on this disease requires validated animal models. One potential animal model that is rapidly gaining in popularity is zebrafish (Danio rerio). The use of zebrafish as an animal model conveys several advantages, including high human genetic homology, transparent embryos and larvae that allow easier visualization. This review discusses how zebrafish models contribute to the development of metabolic syndrome studies. Different diseases in the cluster of metabolic syndrome, such as hyperglycaemia, obesity, diabetes, and hypertriglyceridaemia, have been successfully studied using zebrafish; and the model is promising for hypertension and cardiovascular metabolic-related diseases due to its genetic similarity to mammals. Genetic mutation, chemical induction, and dietary alteration are among the tools used to improve zebrafish models. This field is expanding, and thus, more effective and efficient techniques are currently developed to fulfil the increasing demand for thorough investigations. Key words: diabetes, hypertension, metabolic syndrome, obesity, zebrafish International Press Editing Centre Incorporation 2019-05-21 Article PeerReviewed application/pdf en http://irep.iium.edu.my/79119/1/benchoula%20et%20al%202019-EA.pdf application/pdf en http://irep.iium.edu.my/79119/7/Scopus%20-%20promise%20of%20zebrafish.pdf Benchoula, Khaled and Khatib, Alfi and Jaffar, Ashika and Ahmed, Qamar Uddin and Wan Sulaiman, Wan Mohd. Azizi and Abdul Wahab, Ridhwan and El-Seedi, Hesham (2019) The promise of zebrafish as a model of metabolic syndrome. Experimental Animals, 68 (4). pp. 407-416. ISSN 13411357 https://www.jstage.jst.go.jp/article/expanim/68/4/68_18-0168/_article 10.1538/expanim.18-0168
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Benchoula, Khaled Khatib, Alfi Jaffar, Ashika Ahmed, Qamar Uddin Wan Sulaiman, Wan Mohd. Azizi Abdul Wahab, Ridhwan El-Seedi, Hesham The promise of zebrafish as a model of metabolic syndrome
description	Metabolic syndrome is a cluster including hyperglycaemia, obesity, hypertension, and hypertriglyceridaemia as a result of biochemical and physiological alterations and can increase the risk of cardiovascular disease and diabetes. Fundamental research on this disease requires validated animal models. One potential animal model that is rapidly gaining in popularity is zebrafish (Danio rerio). The use of zebrafish as an animal model conveys several advantages, including high human genetic homology, transparent embryos and larvae that allow easier visualization. This review discusses how zebrafish models contribute to the development of metabolic syndrome studies. Different diseases in the cluster of metabolic syndrome, such as hyperglycaemia, obesity, diabetes, and hypertriglyceridaemia, have been successfully studied using zebrafish; and the model is promising for hypertension and cardiovascular metabolic-related diseases due to its genetic similarity to mammals. Genetic mutation, chemical induction, and dietary alteration are among the tools used to improve zebrafish models. This field is expanding, and thus, more effective and efficient techniques are currently developed to fulfil the increasing demand for thorough investigations. Key words: diabetes, hypertension, metabolic syndrome, obesity, zebrafish
format	Article
author	Benchoula, Khaled Khatib, Alfi Jaffar, Ashika Ahmed, Qamar Uddin Wan Sulaiman, Wan Mohd. Azizi Abdul Wahab, Ridhwan El-Seedi, Hesham
author_facet	Benchoula, Khaled Khatib, Alfi Jaffar, Ashika Ahmed, Qamar Uddin Wan Sulaiman, Wan Mohd. Azizi Abdul Wahab, Ridhwan El-Seedi, Hesham
author_sort	Benchoula, Khaled
title	The promise of zebrafish as a model of metabolic syndrome
title_short	The promise of zebrafish as a model of metabolic syndrome
title_full	The promise of zebrafish as a model of metabolic syndrome
title_fullStr	The promise of zebrafish as a model of metabolic syndrome
title_full_unstemmed	The promise of zebrafish as a model of metabolic syndrome
title_sort	promise of zebrafish as a model of metabolic syndrome
publisher	International Press Editing Centre Incorporation
publishDate	2019
url	http://irep.iium.edu.my/79119/ http://irep.iium.edu.my/79119/ http://irep.iium.edu.my/79119/ http://irep.iium.edu.my/79119/1/benchoula%20et%20al%202019-EA.pdf http://irep.iium.edu.my/79119/7/Scopus%20-%20promise%20of%20zebrafish.pdf
first_indexed	2023-09-18T21:51:16Z
last_indexed	2023-09-18T21:51:16Z
_version_	1777413784690753536

The promise of zebrafish as a model of metabolic syndrome

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