Alpinia zerumbet (Pers.): Food and medicinal plant with potential in vitro and in vivo anti-cancer activities

Background/Aim: Plants play an important role in anti-cancer drug discovery, therefore, the current study aimed to evaluate the biological activity of Alpinia zerumbet (A. zerumbet) flowers. Methods: The phytochemical and biological criteria of A. zerumbet were in vitro investigated as well as in mo...

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Main Authors:	Hussein Zahra, Maram, Salem, Tarek A.R., El-Araag, Bishoy, Yosri, Nermeen, EL-Ghiban, Samah, Zaki, Kholoud, H. Marei, Amel, Abd El_Wahed, Aida, Saeed, Aamer, Khatib, Alfi, Alajmi, Mohamed Fahad, M. Shatili, Abdulrahman, Xiao, Jianbo, Khalifa, Shaden Ali M., El-Seedi, Hesham Rushdey
Format:	Article
Language:	English English
Published:	MDPI AG 2019
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/78882/ http://irep.iium.edu.my/78882/ http://irep.iium.edu.my/78882/ http://irep.iium.edu.my/78882/1/78882_Alpinia%20zerumbet%20%28Pers.%29.pdf http://irep.iium.edu.my/78882/2/78882_Alpinia%20zerumbet%20%28Pers.%29_SCOPUS.pdf

id	iium-78882
recordtype	eprints
spelling	iium-788822020-02-20T08:30:36Z http://irep.iium.edu.my/78882/ Alpinia zerumbet (Pers.): Food and medicinal plant with potential in vitro and in vivo anti-cancer activities Hussein Zahra, Maram Salem, Tarek A.R. El-Araag, Bishoy Yosri, Nermeen EL-Ghiban, Samah Zaki, Kholoud H. Marei, Amel Abd El_Wahed, Aida Saeed, Aamer Khatib, Alfi Alajmi, Mohamed Fahad M. Shatili, Abdulrahman Xiao, Jianbo Khalifa, Shaden Ali M. El-Seedi, Hesham Rushdey RS Pharmacy and materia medica Background/Aim: Plants play an important role in anti-cancer drug discovery, therefore, the current study aimed to evaluate the biological activity of Alpinia zerumbet (A. zerumbet) flowers. Methods: The phytochemical and biological criteria of A. zerumbet were in vitro investigated as well as in mouse xenograft model. Results: A. zerumbet extracts, specially CH2Cl2 and MeOH extracts, exhibited the highest potent anti-tumor activity against Ehrlich ascites carcinoma (EAC) cells. The most active CH2Cl2 extract was subjected to bioassay-guided fractionation leading to isolatation of the naturally occurring 5,6-dehydrokawain (DK) which was characterized by IR, MS, 1H-NMR and 13C-NMR. A. zerumbet extracts, specially MeOH and CH2Cl2 extracts, exhibited significant inhibitory activity towards tumor volume (TV). Furthermore, A. zerumbet extracts declined the high level of malonaldehyde (MDA) as well as elevated the levels of superoxide dismutase (SOD) and catalase (CAT) in liver tissue homogenate. Moreover, DK showed anti-proliferative action on different human cancer cell lines. The recorded IC50 values against breast carcinoma (MCF-7), liver carcinoma (Hep-G2) and larynx carcinoma cells (HEP-2) were 3.08, 6.8, and 8.7 µg/mL, respectively. Conclusion: Taken together, these findings open the door for further investigations in order to explore the potential medicinal properties of A. zerumbet. MDPI AG 2019 Article PeerReviewed application/pdf en http://irep.iium.edu.my/78882/1/78882_Alpinia%20zerumbet%20%28Pers.%29.pdf application/pdf en http://irep.iium.edu.my/78882/2/78882_Alpinia%20zerumbet%20%28Pers.%29_SCOPUS.pdf Hussein Zahra, Maram and Salem, Tarek A.R. and El-Araag, Bishoy and Yosri, Nermeen and EL-Ghiban, Samah and Zaki, Kholoud and H. Marei, Amel and Abd El_Wahed, Aida and Saeed, Aamer and Khatib, Alfi and Alajmi, Mohamed Fahad and M. Shatili, Abdulrahman and Xiao, Jianbo and Khalifa, Shaden Ali M. and El-Seedi, Hesham Rushdey (2019) Alpinia zerumbet (Pers.): Food and medicinal plant with potential in vitro and in vivo anti-cancer activities. Molecules, 24 (13). pp. 1-14. ISSN 14203049 https://www.mdpi.com/1420-3049/24/13/2495 https://doi.org/10.3390/molecules24132495
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Hussein Zahra, Maram Salem, Tarek A.R. El-Araag, Bishoy Yosri, Nermeen EL-Ghiban, Samah Zaki, Kholoud H. Marei, Amel Abd El_Wahed, Aida Saeed, Aamer Khatib, Alfi Alajmi, Mohamed Fahad M. Shatili, Abdulrahman Xiao, Jianbo Khalifa, Shaden Ali M. El-Seedi, Hesham Rushdey Alpinia zerumbet (Pers.): Food and medicinal plant with potential in vitro and in vivo anti-cancer activities
description	Background/Aim: Plants play an important role in anti-cancer drug discovery, therefore, the current study aimed to evaluate the biological activity of Alpinia zerumbet (A. zerumbet) flowers. Methods: The phytochemical and biological criteria of A. zerumbet were in vitro investigated as well as in mouse xenograft model. Results: A. zerumbet extracts, specially CH2Cl2 and MeOH extracts, exhibited the highest potent anti-tumor activity against Ehrlich ascites carcinoma (EAC) cells. The most active CH2Cl2 extract was subjected to bioassay-guided fractionation leading to isolatation of the naturally occurring 5,6-dehydrokawain (DK) which was characterized by IR, MS, 1H-NMR and 13C-NMR. A. zerumbet extracts, specially MeOH and CH2Cl2 extracts, exhibited significant inhibitory activity towards tumor volume (TV). Furthermore, A. zerumbet extracts declined the high level of malonaldehyde (MDA) as well as elevated the levels of superoxide dismutase (SOD) and catalase (CAT) in liver tissue homogenate. Moreover, DK showed anti-proliferative action on different human cancer cell lines. The recorded IC50 values against breast carcinoma (MCF-7), liver carcinoma (Hep-G2) and larynx carcinoma cells (HEP-2) were 3.08, 6.8, and 8.7 µg/mL, respectively. Conclusion: Taken together, these findings open the door for further investigations in order to explore the potential medicinal properties of A. zerumbet.
format	Article
author	Hussein Zahra, Maram Salem, Tarek A.R. El-Araag, Bishoy Yosri, Nermeen EL-Ghiban, Samah Zaki, Kholoud H. Marei, Amel Abd El_Wahed, Aida Saeed, Aamer Khatib, Alfi Alajmi, Mohamed Fahad M. Shatili, Abdulrahman Xiao, Jianbo Khalifa, Shaden Ali M. El-Seedi, Hesham Rushdey
author_facet	Hussein Zahra, Maram Salem, Tarek A.R. El-Araag, Bishoy Yosri, Nermeen EL-Ghiban, Samah Zaki, Kholoud H. Marei, Amel Abd El_Wahed, Aida Saeed, Aamer Khatib, Alfi Alajmi, Mohamed Fahad M. Shatili, Abdulrahman Xiao, Jianbo Khalifa, Shaden Ali M. El-Seedi, Hesham Rushdey
author_sort	Hussein Zahra, Maram
title	Alpinia zerumbet (Pers.): Food and medicinal plant with potential in vitro and in vivo anti-cancer activities
title_short	Alpinia zerumbet (Pers.): Food and medicinal plant with potential in vitro and in vivo anti-cancer activities
title_full	Alpinia zerumbet (Pers.): Food and medicinal plant with potential in vitro and in vivo anti-cancer activities
title_fullStr	Alpinia zerumbet (Pers.): Food and medicinal plant with potential in vitro and in vivo anti-cancer activities
title_full_unstemmed	Alpinia zerumbet (Pers.): Food and medicinal plant with potential in vitro and in vivo anti-cancer activities
title_sort	alpinia zerumbet (pers.): food and medicinal plant with potential in vitro and in vivo anti-cancer activities
publisher	MDPI AG
publishDate	2019
url	http://irep.iium.edu.my/78882/ http://irep.iium.edu.my/78882/ http://irep.iium.edu.my/78882/ http://irep.iium.edu.my/78882/1/78882_Alpinia%20zerumbet%20%28Pers.%29.pdf http://irep.iium.edu.my/78882/2/78882_Alpinia%20zerumbet%20%28Pers.%29_SCOPUS.pdf
first_indexed	2023-09-18T21:51:02Z
last_indexed	2023-09-18T21:51:02Z
_version_	1777413770566434816

Alpinia zerumbet (Pers.): Food and medicinal plant with potential in vitro and in vivo anti-cancer activities

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