Time to treatment initiation (TTI) and retrospective analysis of antiretroviral therapy (ART) outcomes among HIV-positive Methadone Maintenance Therapy clients In primary health care centres, Kuantan, Pahang.

Introduction: Methadone Maintenance Therapy (MMT) program improves access to antiretroviral therapy (ART) among people who inject drugs (PWID) with HIV-positive status. However, the time to treatment initiation (TTI) and outcomes of ART intervention in this population has scarcely been analysed. Obj...

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Main Authors:	Ramlan, Aida Roziana, Mohamed Nazar, Nor Ilyani, Tumian, Afidalina, Ab Rahman, Norny Syafinaz, Mohamad, Dzawani, Abdul Talib, Mat Sharil, Zakaria, Mohd Khairul Faizan, Izuddin, Muhammad Azzim, Zainal Abidin, Nadia Akmal, Tunku Syed Manso, Syarifah Syafiqah, W Hassan, W N Khairiyah
Format:	Conference or Workshop Item
Language:	English English English
Published:	2019
Subjects:	RM147 Administration of Drugs and Other Therapeutic Agents
Online Access:	http://irep.iium.edu.my/78782/ http://irep.iium.edu.my/78782/3/ICPRP%20aida%20final%20edit%20for%20%20presentation.pdf http://irep.iium.edu.my/78782/4/abstract_2019.pdf http://irep.iium.edu.my/78782/5/Oral%20schedule.pdf

id	iium-78782
recordtype	eprints
spelling	iium-787822020-02-24T02:28:18Z http://irep.iium.edu.my/78782/ Time to treatment initiation (TTI) and retrospective analysis of antiretroviral therapy (ART) outcomes among HIV-positive Methadone Maintenance Therapy clients In primary health care centres, Kuantan, Pahang. Ramlan, Aida Roziana Mohamed Nazar, Nor Ilyani Tumian, Afidalina Ab Rahman, Norny Syafinaz Mohamad, Dzawani Abdul Talib, Mat Sharil Zakaria, Mohd Khairul Faizan Izuddin, Muhammad Azzim Zainal Abidin, Nadia Akmal Tunku Syed Manso, Syarifah Syafiqah W Hassan, W N Khairiyah RM147 Administration of Drugs and Other Therapeutic Agents Introduction: Methadone Maintenance Therapy (MMT) program improves access to antiretroviral therapy (ART) among people who inject drugs (PWID) with HIV-positive status. However, the time to treatment initiation (TTI) and outcomes of ART intervention in this population has scarcely been analysed. Objectives: This study aimed to analyse the TTI and outcomes of ART among MMT clients in primary health care centres in Kuantan, Pahang. Materials and Methods: This is a retrospective evaluation of MMT clients’ records from the year 2006 to 2019. The TTI was calculated from the day of diagnosis to ART initiation. The trends of CD4 counts and viral loads were descriptively evaluated. Cox proportional hazard model was used to analyse the survival and treatment retention rate. Results: A total of 67 MMT clients from six primary health care centres were HIV-positive with 37 clients were started on ART. The mean TTI of ART was 27 months. The clients who were given ART had a median CD4 count of 119 cells/mm3 at baseline and increased to 219 cells/mm3 after six months of ART. Only two patients (5.4%) in the ART group had an unsuppressed viral load. The initiation of ART had reduced the risk of death by 72.8% (hazard ratio = 0.27, p=0.024), and they are 13.1 times more likely to retain in treatment (p<0.01). Conclusion: The TTI of ART was delayed in this population. MMT clients who were given ART have better CD4 and viral loads outcomes, helped reduced death risk and showed higher retention rates in the MMT program. 2019-10-20 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/78782/3/ICPRP%20aida%20final%20edit%20for%20%20presentation.pdf application/pdf en http://irep.iium.edu.my/78782/4/abstract_2019.pdf application/pdf en http://irep.iium.edu.my/78782/5/Oral%20schedule.pdf Ramlan, Aida Roziana and Mohamed Nazar, Nor Ilyani and Tumian, Afidalina and Ab Rahman, Norny Syafinaz and Mohamad, Dzawani and Abdul Talib, Mat Sharil and Zakaria, Mohd Khairul Faizan and Izuddin, Muhammad Azzim and Zainal Abidin, Nadia Akmal and Tunku Syed Manso, Syarifah Syafiqah and W Hassan, W N Khairiyah (2019) Time to treatment initiation (TTI) and retrospective analysis of antiretroviral therapy (ART) outcomes among HIV-positive Methadone Maintenance Therapy clients In primary health care centres, Kuantan, Pahang. In: International Conference on Pharmaceutical Research and Pharmacy Practice cum 14th IIUM-MPS Pharmacy Scientific Conference (ICPRP 2019), 19-20th October 2019, Hotel Istana Kuala Lumpur. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	RM147 Administration of Drugs and Other Therapeutic Agents
spellingShingle	RM147 Administration of Drugs and Other Therapeutic Agents Ramlan, Aida Roziana Mohamed Nazar, Nor Ilyani Tumian, Afidalina Ab Rahman, Norny Syafinaz Mohamad, Dzawani Abdul Talib, Mat Sharil Zakaria, Mohd Khairul Faizan Izuddin, Muhammad Azzim Zainal Abidin, Nadia Akmal Tunku Syed Manso, Syarifah Syafiqah W Hassan, W N Khairiyah Time to treatment initiation (TTI) and retrospective analysis of antiretroviral therapy (ART) outcomes among HIV-positive Methadone Maintenance Therapy clients In primary health care centres, Kuantan, Pahang.
description	Introduction: Methadone Maintenance Therapy (MMT) program improves access to antiretroviral therapy (ART) among people who inject drugs (PWID) with HIV-positive status. However, the time to treatment initiation (TTI) and outcomes of ART intervention in this population has scarcely been analysed. Objectives: This study aimed to analyse the TTI and outcomes of ART among MMT clients in primary health care centres in Kuantan, Pahang. Materials and Methods: This is a retrospective evaluation of MMT clients’ records from the year 2006 to 2019. The TTI was calculated from the day of diagnosis to ART initiation. The trends of CD4 counts and viral loads were descriptively evaluated. Cox proportional hazard model was used to analyse the survival and treatment retention rate. Results: A total of 67 MMT clients from six primary health care centres were HIV-positive with 37 clients were started on ART. The mean TTI of ART was 27 months. The clients who were given ART had a median CD4 count of 119 cells/mm3 at baseline and increased to 219 cells/mm3 after six months of ART. Only two patients (5.4%) in the ART group had an unsuppressed viral load. The initiation of ART had reduced the risk of death by 72.8% (hazard ratio = 0.27, p=0.024), and they are 13.1 times more likely to retain in treatment (p<0.01). Conclusion: The TTI of ART was delayed in this population. MMT clients who were given ART have better CD4 and viral loads outcomes, helped reduced death risk and showed higher retention rates in the MMT program.
format	Conference or Workshop Item
author	Ramlan, Aida Roziana Mohamed Nazar, Nor Ilyani Tumian, Afidalina Ab Rahman, Norny Syafinaz Mohamad, Dzawani Abdul Talib, Mat Sharil Zakaria, Mohd Khairul Faizan Izuddin, Muhammad Azzim Zainal Abidin, Nadia Akmal Tunku Syed Manso, Syarifah Syafiqah W Hassan, W N Khairiyah
author_facet	Ramlan, Aida Roziana Mohamed Nazar, Nor Ilyani Tumian, Afidalina Ab Rahman, Norny Syafinaz Mohamad, Dzawani Abdul Talib, Mat Sharil Zakaria, Mohd Khairul Faizan Izuddin, Muhammad Azzim Zainal Abidin, Nadia Akmal Tunku Syed Manso, Syarifah Syafiqah W Hassan, W N Khairiyah
author_sort	Ramlan, Aida Roziana
title	Time to treatment initiation (TTI) and retrospective analysis of antiretroviral therapy (ART) outcomes among HIV-positive Methadone Maintenance Therapy clients In primary health care centres, Kuantan, Pahang.
title_short	Time to treatment initiation (TTI) and retrospective analysis of antiretroviral therapy (ART) outcomes among HIV-positive Methadone Maintenance Therapy clients In primary health care centres, Kuantan, Pahang.
title_full	Time to treatment initiation (TTI) and retrospective analysis of antiretroviral therapy (ART) outcomes among HIV-positive Methadone Maintenance Therapy clients In primary health care centres, Kuantan, Pahang.
title_fullStr	Time to treatment initiation (TTI) and retrospective analysis of antiretroviral therapy (ART) outcomes among HIV-positive Methadone Maintenance Therapy clients In primary health care centres, Kuantan, Pahang.
title_full_unstemmed	Time to treatment initiation (TTI) and retrospective analysis of antiretroviral therapy (ART) outcomes among HIV-positive Methadone Maintenance Therapy clients In primary health care centres, Kuantan, Pahang.
title_sort	time to treatment initiation (tti) and retrospective analysis of antiretroviral therapy (art) outcomes among hiv-positive methadone maintenance therapy clients in primary health care centres, kuantan, pahang.
publishDate	2019
url	http://irep.iium.edu.my/78782/ http://irep.iium.edu.my/78782/3/ICPRP%20aida%20final%20edit%20for%20%20presentation.pdf http://irep.iium.edu.my/78782/4/abstract_2019.pdf http://irep.iium.edu.my/78782/5/Oral%20schedule.pdf
first_indexed	2023-09-18T21:50:55Z
last_indexed	2023-09-18T21:50:55Z
_version_	1777413762609840128

Time to treatment initiation (TTI) and retrospective analysis of antiretroviral therapy (ART) outcomes among HIV-positive Methadone Maintenance Therapy clients In primary health care centres, Kuantan, Pahang.

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