The crystal structure and cytotoxicity of Centrosymmetric Copper(II) complex derived from S-methyldithiocarbazate with isatin

The crystal structure and cytotoxicity of Centrosymmetric Copper(II) complex derived from S-methyldithiocarbazate with isatin

Copper(II) complex of S-methyldithiocarbazate with isatin has been prepared and screened for their cytotoxic activities against MCF-7 (Human non-metastatic mammary gland adenocarcinoma cell line) and MDA-MB- 231 (Human metastatic mammary gland adenocarcinoma cell line). The compound crystallized in...

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Main Authors: Abdul Manan, Mohd Abdul Fatah, Mohamed Tahir, Mohamed Ibrahim, Crouse, Karen Anne, Rosli, Rozita, How, Fiona Ni Foong, Watkins, David J.
Format: Article
Language:English
Published: Springer New York LLC 2011
Subjects:
QD Chemistry
Online Access:http://irep.iium.edu.my/7867/
http://irep.iium.edu.my/7867/
http://irep.iium.edu.my/7867/
http://irep.iium.edu.my/7867/1/JOCC_41_1866-1871.pdf
id iium-7867
recordtype eprints
spelling iium-78672013-06-25T02:59:40Z http://irep.iium.edu.my/7867/ The crystal structure and cytotoxicity of Centrosymmetric Copper(II) complex derived from S-methyldithiocarbazate with isatin Abdul Manan, Mohd Abdul Fatah Mohamed Tahir, Mohamed Ibrahim Crouse, Karen Anne Rosli, Rozita How, Fiona Ni Foong Watkins, David J. QD Chemistry Copper(II) complex of S-methyldithiocarbazate with isatin has been prepared and screened for their cytotoxic activities against MCF-7 (Human non-metastatic mammary gland adenocarcinoma cell line) and MDA-MB- 231 (Human metastatic mammary gland adenocarcinoma cell line). The compound crystallized in an orthorhombic crystal system with a space group C 2cb and was found to be selectively active against MCF-7 cell line (Human nonmetastatic mammary gland adenocarcinoma cell line with an IC50 value 0.45 lg/mL. The crystal structure of this centrosymmetric Cu(SMISA)2 complex (SMISA = Schiff base formed by condensation reaction of S-methyldithiocarbazate with isatin) showed that the copper atom has a distorted square-planar geometry with the Schiff base coordinated to the metal ion as a uninegatively charged bidentate ligand through the azomethine nitrogen and thiolate sulfur. Springer New York LLC 2011-10-11 Article PeerReviewed application/pdf en http://irep.iium.edu.my/7867/1/JOCC_41_1866-1871.pdf Abdul Manan, Mohd Abdul Fatah and Mohamed Tahir, Mohamed Ibrahim and Crouse, Karen Anne and Rosli, Rozita and How, Fiona Ni Foong and Watkins, David J. (2011) The crystal structure and cytotoxicity of Centrosymmetric Copper(II) complex derived from S-methyldithiocarbazate with isatin. Journal of Chemical Crystallography, 41 (12). pp. 1866-1871. ISSN 1074-1542 http://www.springerlink.com/content/05mt681765j6w7qg/ 10.1007/s10870-011-0190-8
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
topic QD Chemistry
spellingShingle QD Chemistry
Abdul Manan, Mohd Abdul Fatah
Mohamed Tahir, Mohamed Ibrahim
Crouse, Karen Anne
Rosli, Rozita
How, Fiona Ni Foong
Watkins, David J.
The crystal structure and cytotoxicity of Centrosymmetric Copper(II) complex derived from S-methyldithiocarbazate with isatin
description Copper(II) complex of S-methyldithiocarbazate with isatin has been prepared and screened for their cytotoxic activities against MCF-7 (Human non-metastatic mammary gland adenocarcinoma cell line) and MDA-MB- 231 (Human metastatic mammary gland adenocarcinoma cell line). The compound crystallized in an orthorhombic crystal system with a space group C 2cb and was found to be selectively active against MCF-7 cell line (Human nonmetastatic mammary gland adenocarcinoma cell line with an IC50 value 0.45 lg/mL. The crystal structure of this centrosymmetric Cu(SMISA)2 complex (SMISA = Schiff base formed by condensation reaction of S-methyldithiocarbazate with isatin) showed that the copper atom has a distorted square-planar geometry with the Schiff base coordinated to the metal ion as a uninegatively charged bidentate ligand through the azomethine nitrogen and thiolate sulfur.
format Article
author Abdul Manan, Mohd Abdul Fatah
Mohamed Tahir, Mohamed Ibrahim
Crouse, Karen Anne
Rosli, Rozita
How, Fiona Ni Foong
Watkins, David J.
author_facet Abdul Manan, Mohd Abdul Fatah
Mohamed Tahir, Mohamed Ibrahim
Crouse, Karen Anne
Rosli, Rozita
How, Fiona Ni Foong
Watkins, David J.
author_sort Abdul Manan, Mohd Abdul Fatah
title The crystal structure and cytotoxicity of Centrosymmetric Copper(II) complex derived from S-methyldithiocarbazate with isatin
title_short The crystal structure and cytotoxicity of Centrosymmetric Copper(II) complex derived from S-methyldithiocarbazate with isatin
title_full The crystal structure and cytotoxicity of Centrosymmetric Copper(II) complex derived from S-methyldithiocarbazate with isatin
title_fullStr The crystal structure and cytotoxicity of Centrosymmetric Copper(II) complex derived from S-methyldithiocarbazate with isatin
title_full_unstemmed The crystal structure and cytotoxicity of Centrosymmetric Copper(II) complex derived from S-methyldithiocarbazate with isatin
title_sort crystal structure and cytotoxicity of centrosymmetric copper(ii) complex derived from s-methyldithiocarbazate with isatin
publisher Springer New York LLC
publishDate 2011
url http://irep.iium.edu.my/7867/
http://irep.iium.edu.my/7867/
http://irep.iium.edu.my/7867/
http://irep.iium.edu.my/7867/1/JOCC_41_1866-1871.pdf
first_indexed 2023-09-18T20:17:25Z
last_indexed 2023-09-18T20:17:25Z
_version_ 1777407880489598976

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