Synthesis and characterization of orotic acid loaded chitosan inclusion complex

Background: Polymeric inclusion complex has been used frequently as a drug delivery system due to controlled release, non-toxic properties and high bioavailability. Objective: The current study aims to improve drug release properties of orotic acid loaded with chitosan inclusion complex (OA/CS). Mat...

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Main Authors:	Hassani, Abdelkader, Azad, Abul Kalam, Mia, Abdur Rashid, Helaluddin, Abul Bashar Mohammed
Format:	Conference or Workshop Item
Language:	English English
Published:	2019
Subjects:	QD Chemistry RS192 Materia Medica-Pharmaceutical Technology RS403 Materia Medica-Pharmaceutical Chemistry
Online Access:	http://irep.iium.edu.my/77755/ http://irep.iium.edu.my/77755/1/AIPC2019BookofAbstracts-1.pdf http://irep.iium.edu.my/77755/7/AIPC%202019%20helal.pdf

id	iium-77755
recordtype	eprints
spelling	iium-777552020-01-28T03:19:18Z http://irep.iium.edu.my/77755/ Synthesis and characterization of orotic acid loaded chitosan inclusion complex Hassani, Abdelkader Azad, Abul Kalam Mia, Abdur Rashid Helaluddin, Abul Bashar Mohammed QD Chemistry RS192 Materia Medica-Pharmaceutical Technology RS403 Materia Medica-Pharmaceutical Chemistry Background: Polymeric inclusion complex has been used frequently as a drug delivery system due to controlled release, non-toxic properties and high bioavailability. Objective: The current study aims to improve drug release properties of orotic acid loaded with chitosan inclusion complex (OA/CS). Material and methods: The OA/CS inclusion complex were synthesized using freeze drying technique. The characterization of inclusion OA/CS was carried out using Fourier Transform Infrared Spectroscopy (FTIR), X-ray Diffractometry (XRD), Differential Scanning Calorimetry (DSC), Zeta sizer, and Transmission Electron Microscopy (TEM). Results: The FTIR peaks of orotic acid have almost vanished in the OA/CS spectrum due to the restriction of OA vibration upon loading in CS cavity. The diffraction peaks of the OA/CS are completely diffused due to the amorphous state and the lack of crystallinity of inclusion complex. The DSC marked changes are indicative of the amorphous phase of solid dispersion, as well OA encapsulation into the nanocavity of CS. The size of OA/CS ranged between 58 nm and 200 nm and the zeta potential was 30 mV. In addition, transmission electron microscopy (TEM) showed that OA/CS sizes were ranged from 20 to 45 nm. Conclusion: Thus, this study indicates that OA/CS has promising future to further develop a carrier for drug delivery systems. 2019 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/77755/1/AIPC2019BookofAbstracts-1.pdf application/pdf en http://irep.iium.edu.my/77755/7/AIPC%202019%20helal.pdf Hassani, Abdelkader and Azad, Abul Kalam and Mia, Abdur Rashid and Helaluddin, Abul Bashar Mohammed (2019) Synthesis and characterization of orotic acid loaded chitosan inclusion complex. In: AIMST International Pharmacy Conference (AIPC) 2019: Challenges and Opportunities in Pharmaceutical Sciences, Technology and Practice, 30 November - 1 December 2019, Faculty of Pharmacy, AIMST University, Semeling, Kedah. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	QD Chemistry RS192 Materia Medica-Pharmaceutical Technology RS403 Materia Medica-Pharmaceutical Chemistry
spellingShingle	QD Chemistry RS192 Materia Medica-Pharmaceutical Technology RS403 Materia Medica-Pharmaceutical Chemistry Hassani, Abdelkader Azad, Abul Kalam Mia, Abdur Rashid Helaluddin, Abul Bashar Mohammed Synthesis and characterization of orotic acid loaded chitosan inclusion complex
description	Background: Polymeric inclusion complex has been used frequently as a drug delivery system due to controlled release, non-toxic properties and high bioavailability. Objective: The current study aims to improve drug release properties of orotic acid loaded with chitosan inclusion complex (OA/CS). Material and methods: The OA/CS inclusion complex were synthesized using freeze drying technique. The characterization of inclusion OA/CS was carried out using Fourier Transform Infrared Spectroscopy (FTIR), X-ray Diffractometry (XRD), Differential Scanning Calorimetry (DSC), Zeta sizer, and Transmission Electron Microscopy (TEM). Results: The FTIR peaks of orotic acid have almost vanished in the OA/CS spectrum due to the restriction of OA vibration upon loading in CS cavity. The diffraction peaks of the OA/CS are completely diffused due to the amorphous state and the lack of crystallinity of inclusion complex. The DSC marked changes are indicative of the amorphous phase of solid dispersion, as well OA encapsulation into the nanocavity of CS. The size of OA/CS ranged between 58 nm and 200 nm and the zeta potential was 30 mV. In addition, transmission electron microscopy (TEM) showed that OA/CS sizes were ranged from 20 to 45 nm. Conclusion: Thus, this study indicates that OA/CS has promising future to further develop a carrier for drug delivery systems.
format	Conference or Workshop Item
author	Hassani, Abdelkader Azad, Abul Kalam Mia, Abdur Rashid Helaluddin, Abul Bashar Mohammed
author_facet	Hassani, Abdelkader Azad, Abul Kalam Mia, Abdur Rashid Helaluddin, Abul Bashar Mohammed
author_sort	Hassani, Abdelkader
title	Synthesis and characterization of orotic acid loaded chitosan inclusion complex
title_short	Synthesis and characterization of orotic acid loaded chitosan inclusion complex
title_full	Synthesis and characterization of orotic acid loaded chitosan inclusion complex
title_fullStr	Synthesis and characterization of orotic acid loaded chitosan inclusion complex
title_full_unstemmed	Synthesis and characterization of orotic acid loaded chitosan inclusion complex
title_sort	synthesis and characterization of orotic acid loaded chitosan inclusion complex
publishDate	2019
url	http://irep.iium.edu.my/77755/ http://irep.iium.edu.my/77755/1/AIPC2019BookofAbstracts-1.pdf http://irep.iium.edu.my/77755/7/AIPC%202019%20helal.pdf
first_indexed	2023-09-18T21:49:39Z
last_indexed	2023-09-18T21:49:39Z
_version_	1777413682926452736

Synthesis and characterization of orotic acid loaded chitosan inclusion complex

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