Electrospun PVA-grapheneoxide-PEDOT:PSS nanofibers for wound healing

Nanotechnology has been broadly acknowledged in scaffold development for wound healing applications. Nanofibers-based scaffolds are highly valued for its mechanical and biological properties. Nonetheless, nanofibers composed of different nanofillers posed enormous challenge in emulating the architec...

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Main Authors:	Barthasarathy, Piravin Raj, Ahmad Shahizam, Zayd, Ihda Uswatun Shalihah, Shohibuddin, Wan Salim, Wan Wardatul Amani
Format:	Conference or Workshop Item
Language:	English English
Published:	2019
Subjects:	RD92 Wounds and injuries TP248.13 Biotechnology
Online Access:	http://irep.iium.edu.my/77686/ http://irep.iium.edu.my/77686/1/KRD%20Poster_piravin%20et%20al.pdf http://irep.iium.edu.my/77686/2/KRD%20acceptance%20Piravin%20et%20al.pdf

id	iium-77686
recordtype	eprints
spelling	iium-776862020-02-04T05:23:07Z http://irep.iium.edu.my/77686/ Electrospun PVA-grapheneoxide-PEDOT:PSS nanofibers for wound healing Barthasarathy, Piravin Raj Ahmad Shahizam, Zayd Ihda Uswatun Shalihah, Shohibuddin Wan Salim, Wan Wardatul Amani RD92 Wounds and injuries TP248.13 Biotechnology Nanotechnology has been broadly acknowledged in scaffold development for wound healing applications. Nanofibers-based scaffolds are highly valued for its mechanical and biological properties. Nonetheless, nanofibers composed of different nanofillers posed enormous challenge in emulating the architecture of extracellular matrix. In our study, we have capitalized the unique property of graphene oxide (GO) and poly(3,4- ethylenedioxythiophene)-poly(styrenesulfonate) (PEDOT:PSS) as nanofillers. Polyvinyl alcohol (PVA), PVA-GO and PVA-GO-PEDOT:PSS composites were electrospun into nanofibers of varying morphological, structural, and mechanical properties. The resulting nanofiber films were analysed using FESEM imaging, FTIR spectroscopy, and Raman spectroscopy. The morphology of resultant nanofibers revealed no evidence of beading and the nanofiber diameters were normally distributed with reasonably low variance (n = 50). The average diameter of PVA nanofibers was 248 ± 51 nm, which increased to 270 ± 94 nm when GO was added, and to 275 ± 140 nm when PEDOT:PSS was incorporated into the electrospun solution. Upon soaking in PBS, PVA nanofibers showed pores formation, while no pores were visible in PVA-GO and PVA-GO-PEDOT:PSS nanofibers. As for FTIR spectra, we observed the broadening of -OH bond and shift to higher wavelength in both solution and nanofibers. Additionally, Raman spectroscopy analysis showed splitting and shifting of D band (1362 and 1409 cm-1) and G band (1504 and 1586 cm-1) in PVA-GO-PEDOT:PSS nanofibers. As for PVAGO nanofibers, we observed shifting of D band (1311 cm-1) and G band (1593 cm-1), with no evidence of band splitting. Our study indicate that PVA-GO-PEDOT:PSS nanofiber has similar tensile strength measurement to native skin, while exhibiting a combination of unique property of PVA, GO and PEDOT:PSS. Hence, we deduce that PVA-GO-PEDOT:PSS nanofiber can serve as a initial template for further modifications and subsequently used to promote wound closure. 2019-10-23 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/77686/1/KRD%20Poster_piravin%20et%20al.pdf application/pdf en http://irep.iium.edu.my/77686/2/KRD%20acceptance%20Piravin%20et%20al.pdf Barthasarathy, Piravin Raj and Ahmad Shahizam, Zayd and Ihda Uswatun Shalihah, Shohibuddin and Wan Salim, Wan Wardatul Amani (2019) Electrospun PVA-grapheneoxide-PEDOT:PSS nanofibers for wound healing. In: IIUM Kuantan Research Day 2019, 19-23 Oct 2019, Grand Hall , Level 1, Office of the Campus, IIUM Bandar Indera Mahkota, 25200 Kuantan. (In Press)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RD92 Wounds and injuries TP248.13 Biotechnology
spellingShingle	RD92 Wounds and injuries TP248.13 Biotechnology Barthasarathy, Piravin Raj Ahmad Shahizam, Zayd Ihda Uswatun Shalihah, Shohibuddin Wan Salim, Wan Wardatul Amani Electrospun PVA-grapheneoxide-PEDOT:PSS nanofibers for wound healing
description	Nanotechnology has been broadly acknowledged in scaffold development for wound healing applications. Nanofibers-based scaffolds are highly valued for its mechanical and biological properties. Nonetheless, nanofibers composed of different nanofillers posed enormous challenge in emulating the architecture of extracellular matrix. In our study, we have capitalized the unique property of graphene oxide (GO) and poly(3,4- ethylenedioxythiophene)-poly(styrenesulfonate) (PEDOT:PSS) as nanofillers. Polyvinyl alcohol (PVA), PVA-GO and PVA-GO-PEDOT:PSS composites were electrospun into nanofibers of varying morphological, structural, and mechanical properties. The resulting nanofiber films were analysed using FESEM imaging, FTIR spectroscopy, and Raman spectroscopy. The morphology of resultant nanofibers revealed no evidence of beading and the nanofiber diameters were normally distributed with reasonably low variance (n = 50). The average diameter of PVA nanofibers was 248 ± 51 nm, which increased to 270 ± 94 nm when GO was added, and to 275 ± 140 nm when PEDOT:PSS was incorporated into the electrospun solution. Upon soaking in PBS, PVA nanofibers showed pores formation, while no pores were visible in PVA-GO and PVA-GO-PEDOT:PSS nanofibers. As for FTIR spectra, we observed the broadening of -OH bond and shift to higher wavelength in both solution and nanofibers. Additionally, Raman spectroscopy analysis showed splitting and shifting of D band (1362 and 1409 cm-1) and G band (1504 and 1586 cm-1) in PVA-GO-PEDOT:PSS nanofibers. As for PVAGO nanofibers, we observed shifting of D band (1311 cm-1) and G band (1593 cm-1), with no evidence of band splitting. Our study indicate that PVA-GO-PEDOT:PSS nanofiber has similar tensile strength measurement to native skin, while exhibiting a combination of unique property of PVA, GO and PEDOT:PSS. Hence, we deduce that PVA-GO-PEDOT:PSS nanofiber can serve as a initial template for further modifications and subsequently used to promote wound closure.
format	Conference or Workshop Item
author	Barthasarathy, Piravin Raj Ahmad Shahizam, Zayd Ihda Uswatun Shalihah, Shohibuddin Wan Salim, Wan Wardatul Amani
author_facet	Barthasarathy, Piravin Raj Ahmad Shahizam, Zayd Ihda Uswatun Shalihah, Shohibuddin Wan Salim, Wan Wardatul Amani
author_sort	Barthasarathy, Piravin Raj
title	Electrospun PVA-grapheneoxide-PEDOT:PSS nanofibers for wound healing
title_short	Electrospun PVA-grapheneoxide-PEDOT:PSS nanofibers for wound healing
title_full	Electrospun PVA-grapheneoxide-PEDOT:PSS nanofibers for wound healing
title_fullStr	Electrospun PVA-grapheneoxide-PEDOT:PSS nanofibers for wound healing
title_full_unstemmed	Electrospun PVA-grapheneoxide-PEDOT:PSS nanofibers for wound healing
title_sort	electrospun pva-grapheneoxide-pedot:pss nanofibers for wound healing
publishDate	2019
url	http://irep.iium.edu.my/77686/ http://irep.iium.edu.my/77686/1/KRD%20Poster_piravin%20et%20al.pdf http://irep.iium.edu.my/77686/2/KRD%20acceptance%20Piravin%20et%20al.pdf
first_indexed	2023-09-18T21:49:35Z
last_indexed	2023-09-18T21:49:35Z
_version_	1777413679179890688

Electrospun PVA-grapheneoxide-PEDOT:PSS nanofibers for wound healing

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