Application of metronidazole loaded membrane for periodontal disease: a brief review

Introduction: Periodontitis is the inflammation of periodontal tissues that support the teeth.86% of adults over the age of 70 suffers at least one case of moderate periodontitis leading to the 25% cases of teeth loss. Guided bone regeneration (GBR) is an effective technique used for periodontium r...

Full description

Bibliographic Details
Main Authors:	Mohd Zayi, Nora Azirah, Mohamed Halim, Muhammad Lutfi, Mohamad, Mohd Yusof
Format:	Conference or Workshop Item
Language:	English English
Published:	2020
Subjects:	Q Science (General) QP Physiology QR Microbiology
Online Access:	http://irep.iium.edu.my/77546/ http://irep.iium.edu.my/77546/1/Nora-Poster%20KRD.pdf http://irep.iium.edu.my/77546/2/KRD%20Abstract-Azirah.pdf

id	iium-77546
recordtype	eprints
spelling	iium-775462020-01-28T05:27:40Z http://irep.iium.edu.my/77546/ Application of metronidazole loaded membrane for periodontal disease: a brief review Mohd Zayi, Nora Azirah Mohamed Halim, Muhammad Lutfi Mohamad, Mohd Yusof Q Science (General) QP Physiology QR Microbiology Introduction: Periodontitis is the inflammation of periodontal tissues that support the teeth.86% of adults over the age of 70 suffers at least one case of moderate periodontitis leading to the 25% cases of teeth loss. Guided bone regeneration (GBR) is an effective technique used for periodontium reconstruction. This technique uses barrier membranes which prevent epithelial growth in the wound site and can be supplemented with antibiotics to protect the wound against opportunistic infections. Traditionally, the clinic therapy for anti-infection is to use antibiotics through injection or oral administration resulted in poor delivery of antibiotic to the defect site leading to cytotoxicity. Metronidazole (MNA), a commonly used antibiotics offers the benefits of a high degree of efficacy and with limited adverse side effects. Purpose: This paper aimed to systematically review the current use metronidazole loaded onto membranes in periodontitis treatment. Methodology: SCOPUS and PubMed databases were used to systematically search the articles. The search strategy performed using following keywords: “metronidazole”, “membrane” and “periodontal disease”. The inclusion criteria were all original studies published in English within 5 years. The exclusion criteria were any dissertations, unpublished documents, and review articles. Result: Initial screening of papers yielded 15 papers (Scopus=9 and Pubmed=6) but only 5 articles met the inclusion criteria dealing with MNA antibiotics delivery. Many of the papers reported MNA in forms of mucoadhesive tablet or gel loaded onto different types of membranes (poly 3-hydroxybutyrate, collagen, and chitosan) as topical application of sustained release of antibiotic. The drug delivery employed were able to deliver desired antibiotics dose to the infected site with an extended period whilst minimizing cytotoxicity. However, high amount of MNA delivered to the defect site leading to cytotoxicity. Conclusion: In conclusion, the use of MNA loaded membrane demonstrated promising results for periodontitis but improvement is needed in terms of drug delivery mechanism. 2020 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/77546/1/Nora-Poster%20KRD.pdf application/pdf en http://irep.iium.edu.my/77546/2/KRD%20Abstract-Azirah.pdf Mohd Zayi, Nora Azirah and Mohamed Halim, Muhammad Lutfi and Mohamad, Mohd Yusof (2020) Application of metronidazole loaded membrane for periodontal disease: a brief review. In: IIUM Kuantan Research Day 2019, 23rd October 2019, Grand Hall, OCD Building IIUM Kuantan Campus. (In Press)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	Q Science (General) QP Physiology QR Microbiology
spellingShingle	Q Science (General) QP Physiology QR Microbiology Mohd Zayi, Nora Azirah Mohamed Halim, Muhammad Lutfi Mohamad, Mohd Yusof Application of metronidazole loaded membrane for periodontal disease: a brief review
description	Introduction: Periodontitis is the inflammation of periodontal tissues that support the teeth.86% of adults over the age of 70 suffers at least one case of moderate periodontitis leading to the 25% cases of teeth loss. Guided bone regeneration (GBR) is an effective technique used for periodontium reconstruction. This technique uses barrier membranes which prevent epithelial growth in the wound site and can be supplemented with antibiotics to protect the wound against opportunistic infections. Traditionally, the clinic therapy for anti-infection is to use antibiotics through injection or oral administration resulted in poor delivery of antibiotic to the defect site leading to cytotoxicity. Metronidazole (MNA), a commonly used antibiotics offers the benefits of a high degree of efficacy and with limited adverse side effects. Purpose: This paper aimed to systematically review the current use metronidazole loaded onto membranes in periodontitis treatment. Methodology: SCOPUS and PubMed databases were used to systematically search the articles. The search strategy performed using following keywords: “metronidazole”, “membrane” and “periodontal disease”. The inclusion criteria were all original studies published in English within 5 years. The exclusion criteria were any dissertations, unpublished documents, and review articles. Result: Initial screening of papers yielded 15 papers (Scopus=9 and Pubmed=6) but only 5 articles met the inclusion criteria dealing with MNA antibiotics delivery. Many of the papers reported MNA in forms of mucoadhesive tablet or gel loaded onto different types of membranes (poly 3-hydroxybutyrate, collagen, and chitosan) as topical application of sustained release of antibiotic. The drug delivery employed were able to deliver desired antibiotics dose to the infected site with an extended period whilst minimizing cytotoxicity. However, high amount of MNA delivered to the defect site leading to cytotoxicity. Conclusion: In conclusion, the use of MNA loaded membrane demonstrated promising results for periodontitis but improvement is needed in terms of drug delivery mechanism.
format	Conference or Workshop Item
author	Mohd Zayi, Nora Azirah Mohamed Halim, Muhammad Lutfi Mohamad, Mohd Yusof
author_facet	Mohd Zayi, Nora Azirah Mohamed Halim, Muhammad Lutfi Mohamad, Mohd Yusof
author_sort	Mohd Zayi, Nora Azirah
title	Application of metronidazole loaded membrane for periodontal disease: a brief review
title_short	Application of metronidazole loaded membrane for periodontal disease: a brief review
title_full	Application of metronidazole loaded membrane for periodontal disease: a brief review
title_fullStr	Application of metronidazole loaded membrane for periodontal disease: a brief review
title_full_unstemmed	Application of metronidazole loaded membrane for periodontal disease: a brief review
title_sort	application of metronidazole loaded membrane for periodontal disease: a brief review
publishDate	2020
url	http://irep.iium.edu.my/77546/ http://irep.iium.edu.my/77546/1/Nora-Poster%20KRD.pdf http://irep.iium.edu.my/77546/2/KRD%20Abstract-Azirah.pdf
first_indexed	2023-09-18T21:49:22Z
last_indexed	2023-09-18T21:49:22Z
_version_	1777413665847246848

Application of metronidazole loaded membrane for periodontal disease: a brief review

Similar Items