Disseminated histoplasmosis mimicking an acute appendicitis

Introduction: Histoplasmosis can present in a myriad of clinical manifestations, which often makes its diagnosis difficult and occasionally, deceptive. Case Report: We describe a case of a 33 years old gentleman who was clinically diagnosed as acute appendicitis at initial presentation in view of...

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Main Authors:	Marzukie, Marsilla Mariaty, Ahmad Affandi, Khairunisa, Yahaya, Azyani, Periyasamy, Petrick
Format:	Article
Language:	English English
Published:	Malaysian Society of Pathologists 2019
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/77510/ http://irep.iium.edu.my/77510/ http://irep.iium.edu.my/77510/1/disseminated-histoplasmosis.pdf http://irep.iium.edu.my/77510/7/77510_Disseminated%20histoplasmosis%20mimicking%20an%20acute%20appendicitis.pdf

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spelling	iium-775102019-12-31T03:24:34Z http://irep.iium.edu.my/77510/ Disseminated histoplasmosis mimicking an acute appendicitis Marzukie, Marsilla Mariaty Ahmad Affandi, Khairunisa Yahaya, Azyani Periyasamy, Petrick R Medicine (General) Introduction: Histoplasmosis can present in a myriad of clinical manifestations, which often makes its diagnosis difficult and occasionally, deceptive. Case Report: We describe a case of a 33 years old gentleman who was clinically diagnosed as acute appendicitis at initial presentation in view of a one-week history of fever, right lower quadrant abdominal pain- and guarding at right iliac fossa. He had thrombocytopenia and lymphopenia on presentation. Mesenteric lymphadenitis and small bowel lesion were found intraoperatively, which was respectively biopsied and resected. Histopathological result confirms disseminated histoplasmosis. Retroviral screen was positive. He was treated with amphotericin B for one week, subsequently switched to oral itraconazole, followed by initiation of highly active antiretroviral therapy (HAART). Discussion: This case illustrates the various nature of histoplasmosis presentation. A high index of suspicion is needed to clinch the diagnosis and subsequently institute prompt treatment as disseminated disease can be fatal if left untreated in an immunosuppressed host. Malaysian Society of Pathologists 2019-08-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/77510/1/disseminated-histoplasmosis.pdf application/pdf en http://irep.iium.edu.my/77510/7/77510_Disseminated%20histoplasmosis%20mimicking%20an%20acute%20appendicitis.pdf Marzukie, Marsilla Mariaty and Ahmad Affandi, Khairunisa and Yahaya, Azyani and Periyasamy, Petrick (2019) Disseminated histoplasmosis mimicking an acute appendicitis. Malaysian Journal of Pathology, 41 (2). pp. 223-227. ISSN 0126-8635 http://www.mjpath.org.my/2019/v41n2/disseminated-histoplasmosis.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Marzukie, Marsilla Mariaty Ahmad Affandi, Khairunisa Yahaya, Azyani Periyasamy, Petrick Disseminated histoplasmosis mimicking an acute appendicitis
description	Introduction: Histoplasmosis can present in a myriad of clinical manifestations, which often makes its diagnosis difficult and occasionally, deceptive. Case Report: We describe a case of a 33 years old gentleman who was clinically diagnosed as acute appendicitis at initial presentation in view of a one-week history of fever, right lower quadrant abdominal pain- and guarding at right iliac fossa. He had thrombocytopenia and lymphopenia on presentation. Mesenteric lymphadenitis and small bowel lesion were found intraoperatively, which was respectively biopsied and resected. Histopathological result confirms disseminated histoplasmosis. Retroviral screen was positive. He was treated with amphotericin B for one week, subsequently switched to oral itraconazole, followed by initiation of highly active antiretroviral therapy (HAART). Discussion: This case illustrates the various nature of histoplasmosis presentation. A high index of suspicion is needed to clinch the diagnosis and subsequently institute prompt treatment as disseminated disease can be fatal if left untreated in an immunosuppressed host.
format	Article
author	Marzukie, Marsilla Mariaty Ahmad Affandi, Khairunisa Yahaya, Azyani Periyasamy, Petrick
author_facet	Marzukie, Marsilla Mariaty Ahmad Affandi, Khairunisa Yahaya, Azyani Periyasamy, Petrick
author_sort	Marzukie, Marsilla Mariaty
title	Disseminated histoplasmosis mimicking an acute appendicitis
title_short	Disseminated histoplasmosis mimicking an acute appendicitis
title_full	Disseminated histoplasmosis mimicking an acute appendicitis
title_fullStr	Disseminated histoplasmosis mimicking an acute appendicitis
title_full_unstemmed	Disseminated histoplasmosis mimicking an acute appendicitis
title_sort	disseminated histoplasmosis mimicking an acute appendicitis
publisher	Malaysian Society of Pathologists
publishDate	2019
url	http://irep.iium.edu.my/77510/ http://irep.iium.edu.my/77510/ http://irep.iium.edu.my/77510/1/disseminated-histoplasmosis.pdf http://irep.iium.edu.my/77510/7/77510_Disseminated%20histoplasmosis%20mimicking%20an%20acute%20appendicitis.pdf
first_indexed	2023-09-18T21:49:19Z
last_indexed	2023-09-18T21:49:19Z
_version_	1777413662784356352

Disseminated histoplasmosis mimicking an acute appendicitis

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