p40 immunohistochemistry is an excellent marker in primary lung squamous cell carcinoma

Background Lung cancer is the third most common cancer worldwide. With major advances in the molecular testing of lung cancers and the introduction of targeted therapies, the distinction between adenocarcinoma and squamous cell carcinoma as well as pathologic subtyping has become important. Recent...

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Main Authors:	Ahmad Affandi, Khairunisa, Tizen, Nur Maya Sabrina, Mustangin, Muaatamarulain, Md Zain, Reena Rahayu
Format:	Article
Language:	English
Published:	The Korean Society of Pathologists and the Korean Society for Cytopathology 2018
Subjects:	RB Pathology
Online Access:	http://irep.iium.edu.my/77508/ http://irep.iium.edu.my/77508/ http://irep.iium.edu.my/77508/ http://irep.iium.edu.my/77508/1/jptm-2018-08-14.pdf

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spelling	iium-775082020-02-14T02:12:37Z http://irep.iium.edu.my/77508/ p40 immunohistochemistry is an excellent marker in primary lung squamous cell carcinoma Ahmad Affandi, Khairunisa Tizen, Nur Maya Sabrina Mustangin, Muaatamarulain Md Zain, Reena Rahayu RB Pathology Background Lung cancer is the third most common cancer worldwide. With major advances in the molecular testing of lung cancers and the introduction of targeted therapies, the distinction between adenocarcinoma and squamous cell carcinoma as well as pathologic subtyping has become important. Recent studies showed that p40 is highly specific for squamous and basal cells and is superior to p63 for diagnosing lung squamous cell carcinoma. The aim of this study was to evaluate the use of p40 immunohistochemical stain in the diagnosis of non-small cell lung carcinoma and its potential to replace current p63 antibody as the best immunohistochemical squamous marker. Methods Seventy formalin-fixed paraffin-embedded cases previously diagnosed as primary lung squamous cell carcinoma (n = 35) and lung adenocarcinoma (n = 35) from January 2008 to December 2016 were retrieved. The results of tumour cell immunoreactivity for p40 and p63 antibodies in lung squamous cell carcinoma and lung adenocarcinoma were compared. Results p40 was expressed in 27 cases of lung squamous cell carcinoma (77.1%). All cases of lung adenocarcinoma (35/35, 100%) were negative for p40. p63 expression was positive in 30 cases of lung squamous cell carcinoma (85.7%) and 13 cases of lung adenocarcinoma (37.1%). Reactivity for both p40 and p63 in lung squamous cell carcinoma was strong and diffuse, whereas variable reactivity was observed in lung adenocarcinoma. Conclusions p40 is an excellent marker for distinguishing lung squamous cell carcinoma from adenocarcinoma, and p40 expression is equivalent to p63 expression in lung squamous cell carcinoma. The Korean Society of Pathologists and the Korean Society for Cytopathology 2018-09 Article PeerReviewed application/pdf en http://irep.iium.edu.my/77508/1/jptm-2018-08-14.pdf Ahmad Affandi, Khairunisa and Tizen, Nur Maya Sabrina and Mustangin, Muaatamarulain and Md Zain, Reena Rahayu (2018) p40 immunohistochemistry is an excellent marker in primary lung squamous cell carcinoma. Journal of Pathology and Translational Medicine, 52 (5). pp. 283-289. ISSN 2383-7837 E-ISSN 2383-7845 https://www.jpatholtm.org/upload/pdf/jptm-2018-08-14.pdf 10.4132/jptm.2018.08.14
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RB Pathology
spellingShingle	RB Pathology Ahmad Affandi, Khairunisa Tizen, Nur Maya Sabrina Mustangin, Muaatamarulain Md Zain, Reena Rahayu p40 immunohistochemistry is an excellent marker in primary lung squamous cell carcinoma
description	Background Lung cancer is the third most common cancer worldwide. With major advances in the molecular testing of lung cancers and the introduction of targeted therapies, the distinction between adenocarcinoma and squamous cell carcinoma as well as pathologic subtyping has become important. Recent studies showed that p40 is highly specific for squamous and basal cells and is superior to p63 for diagnosing lung squamous cell carcinoma. The aim of this study was to evaluate the use of p40 immunohistochemical stain in the diagnosis of non-small cell lung carcinoma and its potential to replace current p63 antibody as the best immunohistochemical squamous marker. Methods Seventy formalin-fixed paraffin-embedded cases previously diagnosed as primary lung squamous cell carcinoma (n = 35) and lung adenocarcinoma (n = 35) from January 2008 to December 2016 were retrieved. The results of tumour cell immunoreactivity for p40 and p63 antibodies in lung squamous cell carcinoma and lung adenocarcinoma were compared. Results p40 was expressed in 27 cases of lung squamous cell carcinoma (77.1%). All cases of lung adenocarcinoma (35/35, 100%) were negative for p40. p63 expression was positive in 30 cases of lung squamous cell carcinoma (85.7%) and 13 cases of lung adenocarcinoma (37.1%). Reactivity for both p40 and p63 in lung squamous cell carcinoma was strong and diffuse, whereas variable reactivity was observed in lung adenocarcinoma. Conclusions p40 is an excellent marker for distinguishing lung squamous cell carcinoma from adenocarcinoma, and p40 expression is equivalent to p63 expression in lung squamous cell carcinoma.
format	Article
author	Ahmad Affandi, Khairunisa Tizen, Nur Maya Sabrina Mustangin, Muaatamarulain Md Zain, Reena Rahayu
author_facet	Ahmad Affandi, Khairunisa Tizen, Nur Maya Sabrina Mustangin, Muaatamarulain Md Zain, Reena Rahayu
author_sort	Ahmad Affandi, Khairunisa
title	p40 immunohistochemistry is an excellent marker in primary lung squamous cell carcinoma
title_short	p40 immunohistochemistry is an excellent marker in primary lung squamous cell carcinoma
title_full	p40 immunohistochemistry is an excellent marker in primary lung squamous cell carcinoma
title_fullStr	p40 immunohistochemistry is an excellent marker in primary lung squamous cell carcinoma
title_full_unstemmed	p40 immunohistochemistry is an excellent marker in primary lung squamous cell carcinoma
title_sort	p40 immunohistochemistry is an excellent marker in primary lung squamous cell carcinoma
publisher	The Korean Society of Pathologists and the Korean Society for Cytopathology
publishDate	2018
url	http://irep.iium.edu.my/77508/ http://irep.iium.edu.my/77508/ http://irep.iium.edu.my/77508/ http://irep.iium.edu.my/77508/1/jptm-2018-08-14.pdf
first_indexed	2023-09-18T21:49:19Z
last_indexed	2023-09-18T21:49:19Z
_version_	1777413662638604288

p40 immunohistochemistry is an excellent marker in primary lung squamous cell carcinoma

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