GCMS-based profiling revealed bioactive compounds from Aquilaria malaccensis leaf extract

Bioactive compounds from plants have been shown to possess therapeutic values which are being used as medicine as well as ingredients for functional foods and nutraceuticals. While qualitative and quantitative studies on the bioactive compounds of plant extract are important to establish their cla...

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Main Authors:	Zainurin, Nur Aimi Aliah, Hashim, Yumi Zuhanis Has-Yun, Mohamed Azmin, Nor Fadhillah, Al-Khatib, Maan Fahmi Rashid
Format:	Conference or Workshop Item
Language:	English
Published:	2019
Subjects:	Q Science (General)
Online Access:	http://irep.iium.edu.my/77253/ http://irep.iium.edu.my/77253/7/77253%20GCMS-based%20Profiling%20Revealed.pdf

id	iium-77253
recordtype	eprints
spelling	iium-772532020-01-23T07:31:59Z http://irep.iium.edu.my/77253/ GCMS-based profiling revealed bioactive compounds from Aquilaria malaccensis leaf extract Zainurin, Nur Aimi Aliah Hashim, Yumi Zuhanis Has-Yun Mohamed Azmin, Nor Fadhillah Al-Khatib, Maan Fahmi Rashid Q Science (General) Bioactive compounds from plants have been shown to possess therapeutic values which are being used as medicine as well as ingredients for functional foods and nutraceuticals. While qualitative and quantitative studies on the bioactive compounds of plant extract are important to establish their claimed therapeutic properties; less is focused on effects and interrelationship of process (extraction) conditions used to obtain the desired bioactive compounds. As such, this study intends to determine the effects of different parameters on the extraction of Aquilaria malaccensis leaf extract (ALEX) bioactive compounds. Metabolite profiling of bioactive compounds of ALEX samples were conducted using gas chromatography-mass spectrometry (GCMS) with subsequent multivariate statistical analysis through principal component analysis (PCA) with the aid of MATLAB software. The GCMS analysis detected diverse potential bioactive compounds in ALEX samples with hydrocarbon, terpenes and esters being the primary groups. n-hexadecanoic acid and hexadecanoic acid, 2-hydroxy-1-(hydroxymethyl)ethyl ester were found to be present in most of the ALEX samples. PCA showed that same Soxhlet extraction parameters were able to cluster the samples together and separate samples extracted with different extraction parameters based on the relative abundance of the particular compounds. In conclusion, it is notable that the samples were significantly separated based on Soxhlet extraction time as compared to the solid to solvent ratio.The findings from this study would facilitate in extraction and purification of the desired bioactive compounds from agarwood leaf that could be further used in development of functional foods and nutraceuticals. 2019 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/77253/7/77253%20GCMS-based%20Profiling%20Revealed.pdf Zainurin, Nur Aimi Aliah and Hashim, Yumi Zuhanis Has-Yun and Mohamed Azmin, Nor Fadhillah and Al-Khatib, Maan Fahmi Rashid (2019) GCMS-based profiling revealed bioactive compounds from Aquilaria malaccensis leaf extract. In: Global Halal Sphere Conference 2019 (GloHaS 2019), 21st-22nd August 2019, Kuala Lumpur, Malaysia. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	Q Science (General)
spellingShingle	Q Science (General) Zainurin, Nur Aimi Aliah Hashim, Yumi Zuhanis Has-Yun Mohamed Azmin, Nor Fadhillah Al-Khatib, Maan Fahmi Rashid GCMS-based profiling revealed bioactive compounds from Aquilaria malaccensis leaf extract
description	Bioactive compounds from plants have been shown to possess therapeutic values which are being used as medicine as well as ingredients for functional foods and nutraceuticals. While qualitative and quantitative studies on the bioactive compounds of plant extract are important to establish their claimed therapeutic properties; less is focused on effects and interrelationship of process (extraction) conditions used to obtain the desired bioactive compounds. As such, this study intends to determine the effects of different parameters on the extraction of Aquilaria malaccensis leaf extract (ALEX) bioactive compounds. Metabolite profiling of bioactive compounds of ALEX samples were conducted using gas chromatography-mass spectrometry (GCMS) with subsequent multivariate statistical analysis through principal component analysis (PCA) with the aid of MATLAB software. The GCMS analysis detected diverse potential bioactive compounds in ALEX samples with hydrocarbon, terpenes and esters being the primary groups. n-hexadecanoic acid and hexadecanoic acid, 2-hydroxy-1-(hydroxymethyl)ethyl ester were found to be present in most of the ALEX samples. PCA showed that same Soxhlet extraction parameters were able to cluster the samples together and separate samples extracted with different extraction parameters based on the relative abundance of the particular compounds. In conclusion, it is notable that the samples were significantly separated based on Soxhlet extraction time as compared to the solid to solvent ratio.The findings from this study would facilitate in extraction and purification of the desired bioactive compounds from agarwood leaf that could be further used in development of functional foods and nutraceuticals.
format	Conference or Workshop Item
author	Zainurin, Nur Aimi Aliah Hashim, Yumi Zuhanis Has-Yun Mohamed Azmin, Nor Fadhillah Al-Khatib, Maan Fahmi Rashid
author_facet	Zainurin, Nur Aimi Aliah Hashim, Yumi Zuhanis Has-Yun Mohamed Azmin, Nor Fadhillah Al-Khatib, Maan Fahmi Rashid
author_sort	Zainurin, Nur Aimi Aliah
title	GCMS-based profiling revealed bioactive compounds from Aquilaria malaccensis leaf extract
title_short	GCMS-based profiling revealed bioactive compounds from Aquilaria malaccensis leaf extract
title_full	GCMS-based profiling revealed bioactive compounds from Aquilaria malaccensis leaf extract
title_fullStr	GCMS-based profiling revealed bioactive compounds from Aquilaria malaccensis leaf extract
title_full_unstemmed	GCMS-based profiling revealed bioactive compounds from Aquilaria malaccensis leaf extract
title_sort	gcms-based profiling revealed bioactive compounds from aquilaria malaccensis leaf extract
publishDate	2019
url	http://irep.iium.edu.my/77253/ http://irep.iium.edu.my/77253/7/77253%20GCMS-based%20Profiling%20Revealed.pdf
first_indexed	2023-09-18T21:48:58Z
last_indexed	2023-09-18T21:48:58Z
_version_	1777413640480096256

GCMS-based profiling revealed bioactive compounds from Aquilaria malaccensis leaf extract

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