Anticancer potential and chemical profile of agarwood hydrosol

This is the first report discussing the chemical profile of agarwood hydrosol and its potential anticancer effects. Agarwood hydrosols, from two batches, obtained from Negeri Sembilan, Malaysia, were used in this study. Calu-3 cancer cells were used as a model cell line for lung cancer. The cells...

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Main Authors:	Mohamed Gameil, Abeir Hussein, Hashim, Yumi Zuhanis Has-Yun, Zainurin, Nur Aimi Aliah, Mohd Salleh, Hamzah, Syed Abdullah, Nadiah
Format:	Article
Language:	English
Published:	UTM Press 2019
Subjects:	Q Science (General)
Online Access:	http://irep.iium.edu.my/77247/ http://irep.iium.edu.my/77247/ http://irep.iium.edu.my/77247/ http://irep.iium.edu.my/77247/1/77247_%20Anticancer%20potential%20and%20chemical.pdf

id	iium-77247
recordtype	eprints
spelling	iium-772472020-01-23T07:08:04Z http://irep.iium.edu.my/77247/ Anticancer potential and chemical profile of agarwood hydrosol Mohamed Gameil, Abeir Hussein Hashim, Yumi Zuhanis Has-Yun Zainurin, Nur Aimi Aliah Mohd Salleh, Hamzah Syed Abdullah, Nadiah Q Science (General) This is the first report discussing the chemical profile of agarwood hydrosol and its potential anticancer effects. Agarwood hydrosols, from two batches, obtained from Negeri Sembilan, Malaysia, were used in this study. Calu-3 cancer cells were used as a model cell line for lung cancer. The cells were cultured in Eagle’s minimum essential medium (EMEM) supplemented with 10% (v/v) fetal bovine serum (FBS). The study was carried out in two phases, namely the anticancer study via an attachment (AT) assay and cell viability (CV) assay, and then profiling the hydrosol from the two batches via GCMS and hSPME-GCMS. Design Expert software’s two-factor face-centered central composite design (FCCCD) was used to study the effects of agarwood hydrosol amount and time of exposure on cell attachment (AT) and viability (CV). The findings suggest that agarwood hydrosols of Aquilaria malaccensis possess both anti-attachment and cytotoxic effects on Calu-3 lung cancer cells. A linear model was developed for anti-attachment effects and a quadratic model for the cytotoxic effects with exposure duration being significant in both cases. From the profiling data, 1- tricosene and 16-hentriacontanone were identified as potential contributors to the anti-attachment and/or cytotoxic activity observed. In conclusion, agarwood hydrosol holds a potential to be further investigated as a source of anti-cancer compounds. UTM Press 2019-09 Article PeerReviewed application/pdf en http://irep.iium.edu.my/77247/1/77247_%20Anticancer%20potential%20and%20chemical.pdf Mohamed Gameil, Abeir Hussein and Hashim, Yumi Zuhanis Has-Yun and Zainurin, Nur Aimi Aliah and Mohd Salleh, Hamzah and Syed Abdullah, Nadiah (2019) Anticancer potential and chemical profile of agarwood hydrosol. Malaysian Journal of Fundamental and Applied Sciences, 15 (5 (September-October)). pp. 761-766. ISSN 2289-5981 E-ISSN 2289-599X https://mjfas.utm.my/index.php/mjfas/article/view/1586/pdf 10.11113/mjfas.v15n5.1586
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	Q Science (General)
spellingShingle	Q Science (General) Mohamed Gameil, Abeir Hussein Hashim, Yumi Zuhanis Has-Yun Zainurin, Nur Aimi Aliah Mohd Salleh, Hamzah Syed Abdullah, Nadiah Anticancer potential and chemical profile of agarwood hydrosol
description	This is the first report discussing the chemical profile of agarwood hydrosol and its potential anticancer effects. Agarwood hydrosols, from two batches, obtained from Negeri Sembilan, Malaysia, were used in this study. Calu-3 cancer cells were used as a model cell line for lung cancer. The cells were cultured in Eagle’s minimum essential medium (EMEM) supplemented with 10% (v/v) fetal bovine serum (FBS). The study was carried out in two phases, namely the anticancer study via an attachment (AT) assay and cell viability (CV) assay, and then profiling the hydrosol from the two batches via GCMS and hSPME-GCMS. Design Expert software’s two-factor face-centered central composite design (FCCCD) was used to study the effects of agarwood hydrosol amount and time of exposure on cell attachment (AT) and viability (CV). The findings suggest that agarwood hydrosols of Aquilaria malaccensis possess both anti-attachment and cytotoxic effects on Calu-3 lung cancer cells. A linear model was developed for anti-attachment effects and a quadratic model for the cytotoxic effects with exposure duration being significant in both cases. From the profiling data, 1- tricosene and 16-hentriacontanone were identified as potential contributors to the anti-attachment and/or cytotoxic activity observed. In conclusion, agarwood hydrosol holds a potential to be further investigated as a source of anti-cancer compounds.
format	Article
author	Mohamed Gameil, Abeir Hussein Hashim, Yumi Zuhanis Has-Yun Zainurin, Nur Aimi Aliah Mohd Salleh, Hamzah Syed Abdullah, Nadiah
author_facet	Mohamed Gameil, Abeir Hussein Hashim, Yumi Zuhanis Has-Yun Zainurin, Nur Aimi Aliah Mohd Salleh, Hamzah Syed Abdullah, Nadiah
author_sort	Mohamed Gameil, Abeir Hussein
title	Anticancer potential and chemical profile of agarwood hydrosol
title_short	Anticancer potential and chemical profile of agarwood hydrosol
title_full	Anticancer potential and chemical profile of agarwood hydrosol
title_fullStr	Anticancer potential and chemical profile of agarwood hydrosol
title_full_unstemmed	Anticancer potential and chemical profile of agarwood hydrosol
title_sort	anticancer potential and chemical profile of agarwood hydrosol
publisher	UTM Press
publishDate	2019
url	http://irep.iium.edu.my/77247/ http://irep.iium.edu.my/77247/ http://irep.iium.edu.my/77247/ http://irep.iium.edu.my/77247/1/77247_%20Anticancer%20potential%20and%20chemical.pdf
first_indexed	2023-09-18T21:48:57Z
last_indexed	2023-09-18T21:48:57Z
_version_	1777413639755530240

Anticancer potential and chemical profile of agarwood hydrosol

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