Effects of agarwood at multiple stages of carcinogenesis: a systematic review
This systematic review sought to determine whether preclinical biological and mechanistic evidences of agarwood materials reported at multiple carcinogenic stages are significant to support plausibility of agarwood materials as potential therapeutics for cancer. Agarwood materials have been repor...
| Main Authors: | , , , , , |
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| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
2019
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/77208/ http://irep.iium.edu.my/77208/7/77208%20abstract.pdf |
| Summary: | This systematic review sought to determine whether preclinical biological and mechanistic
evidences of agarwood materials reported at multiple carcinogenic stages are significant to support
plausibility of agarwood materials as potential therapeutics for cancer. Agarwood materials have been
reported to have pre-clinical (in vitro and in vivo) evidences of anti-cancer effects in various types of
cancer, however the diverse range of types of agarwood species and materials as well as carcinogenesis
stage pose a challenge to discern the potential candidate or scheme for further work. More recent reports
on agarwood toxicity further complicates the search for the potential therapeutics. Study selection
criteria was determined based on framework outlined by the World Cancer Research Fund (WCRF)
International/University of Bristol (UoB). In addition, care was taken to follow PRISMA reporting
guidelines as closely as possible. Anti-cancer effect in the studies must be related to properties of
antigenotoxic, apoptosis, antioxidant, cytotoxic, anti-inflammatory, anti- attachment, anti-spreading,
anti-metastatic and anti-angiogenic. Papers that are published other than in English; review paper,
comments and opinions; short paper (less than 6 pages), poster keynote and abstract; and papers
published in 1900 and below are excluded. Search strategy was applied to selected electronic databases
including Scopus, Springerlink, Taylor & Francis Online, Cambridge Core, Pub MEDLINE, Oxford
Academic, Science Direct and Wiley Online Library. Number of 4473 studies were initially identified
and 860 studies were included following screening. After removing duplicates, 112 papers were further
analysed for eligibility.
Presently, 47 studies judged eligible. Interim findings showed several characteristic trends where
type of materials studied ranges from leaf, branch and essential oil; species studied are region/country
specific but types of cancer studied are not research group-specific. Initial conclusion from the
preclinical studies could be made where different species and types of agarwood material may have
effects at multiple carcinogenesis stage in various types of cancer. |
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