The effect of process parameters in extruding scaffold design using synthetic biomaterials

Open-source 3D printers have become a popular technology for inexpensively and rapidly fabricating threedimensional products, including those for medical use. We developed and tested a nozzle for extruding synthetic biomaterials for fabricating scaffold structures that can be used as a medium for ce...

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Main Authors:	Mohd Ariffin, Khairul Anuar, Sukindar, Nor Aiman, Baharudin, B.T. Hang Tuah, Jaafar, Che Nor Aiza, Ismail, Mohd Idris Shah
Format:	Article
Language:	English English
Published:	ModTech Publishing House 2019
Subjects:	T Technology (General) T175 Industrial research. Research and development
Online Access:	http://irep.iium.edu.my/77162/ http://irep.iium.edu.my/77162/1/05-%20Mohd%20Khairol%20Anuar%20Mohd%20Ariffin%20%282%29.pdf http://irep.iium.edu.my/77162/7/77162_The%20effect%20of%20process%20parameters%20in%20extruding%20scaffold%20design%20using%20synthetic%20biomaterials_Scopus.pdf

id	iium-77162
recordtype	eprints
spelling	iium-771622020-02-24T04:33:00Z http://irep.iium.edu.my/77162/ The effect of process parameters in extruding scaffold design using synthetic biomaterials Mohd Ariffin, Khairul Anuar Sukindar, Nor Aiman Baharudin, B.T. Hang Tuah Jaafar, Che Nor Aiza Ismail, Mohd Idris Shah T Technology (General) T175 Industrial research. Research and development Open-source 3D printers have become a popular technology for inexpensively and rapidly fabricating threedimensional products, including those for medical use. We developed and tested a nozzle for extruding synthetic biomaterials for fabricating scaffold structures that can be used as a medium for cell growth in, for instance, orthopedic replacements. The nozzle was designed iteratively to optimise the die angle, nozzle diameter, and liquefier shape for extruding bioresorbable polymers, and a thermal insulator was installed to maintain consistent temperature in the liquefier chamber. We then fabricated a range of scaffold structure parts with varying percentages of infill material and infill patterns. Analysis of variance tests show that the percentage of infill is a dominant factor affecting the porosity as well as the mechanical properties of the samples. Samples with 10%–30% of infill with a combination of lined infill patterns exhibited 50%–70% porosity with 12–20 MPa compressive strengths. These specifications are well-suited for cell growth. To demonstrate the feasibility of fabricating structures with consistent porosity with open-source printers, a humerus bone was 3D printed using both Polylactic acid (PLA) and polymethylmethacrylate (PMMA) filament, and the porosity was controllable. This study suggests that opensource 3D printers may be used for printing bone replacements in the near future. ModTech Publishing House 2019 Article PeerReviewed application/pdf en http://irep.iium.edu.my/77162/1/05-%20Mohd%20Khairol%20Anuar%20Mohd%20Ariffin%20%282%29.pdf application/pdf en http://irep.iium.edu.my/77162/7/77162_The%20effect%20of%20process%20parameters%20in%20extruding%20scaffold%20design%20using%20synthetic%20biomaterials_Scopus.pdf Mohd Ariffin, Khairul Anuar and Sukindar, Nor Aiman and Baharudin, B.T. Hang Tuah and Jaafar, Che Nor Aiza and Ismail, Mohd Idris Shah (2019) The effect of process parameters in extruding scaffold design using synthetic biomaterials. International Journal of Modern Manufacturing Technologies, XI (3). pp. 35-46. ISSN 2067–3604
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	T Technology (General) T175 Industrial research. Research and development
spellingShingle	T Technology (General) T175 Industrial research. Research and development Mohd Ariffin, Khairul Anuar Sukindar, Nor Aiman Baharudin, B.T. Hang Tuah Jaafar, Che Nor Aiza Ismail, Mohd Idris Shah The effect of process parameters in extruding scaffold design using synthetic biomaterials
description	Open-source 3D printers have become a popular technology for inexpensively and rapidly fabricating threedimensional products, including those for medical use. We developed and tested a nozzle for extruding synthetic biomaterials for fabricating scaffold structures that can be used as a medium for cell growth in, for instance, orthopedic replacements. The nozzle was designed iteratively to optimise the die angle, nozzle diameter, and liquefier shape for extruding bioresorbable polymers, and a thermal insulator was installed to maintain consistent temperature in the liquefier chamber. We then fabricated a range of scaffold structure parts with varying percentages of infill material and infill patterns. Analysis of variance tests show that the percentage of infill is a dominant factor affecting the porosity as well as the mechanical properties of the samples. Samples with 10%–30% of infill with a combination of lined infill patterns exhibited 50%–70% porosity with 12–20 MPa compressive strengths. These specifications are well-suited for cell growth. To demonstrate the feasibility of fabricating structures with consistent porosity with open-source printers, a humerus bone was 3D printed using both Polylactic acid (PLA) and polymethylmethacrylate (PMMA) filament, and the porosity was controllable. This study suggests that opensource 3D printers may be used for printing bone replacements in the near future.
format	Article
author	Mohd Ariffin, Khairul Anuar Sukindar, Nor Aiman Baharudin, B.T. Hang Tuah Jaafar, Che Nor Aiza Ismail, Mohd Idris Shah
author_facet	Mohd Ariffin, Khairul Anuar Sukindar, Nor Aiman Baharudin, B.T. Hang Tuah Jaafar, Che Nor Aiza Ismail, Mohd Idris Shah
author_sort	Mohd Ariffin, Khairul Anuar
title	The effect of process parameters in extruding scaffold design using synthetic biomaterials
title_short	The effect of process parameters in extruding scaffold design using synthetic biomaterials
title_full	The effect of process parameters in extruding scaffold design using synthetic biomaterials
title_fullStr	The effect of process parameters in extruding scaffold design using synthetic biomaterials
title_full_unstemmed	The effect of process parameters in extruding scaffold design using synthetic biomaterials
title_sort	effect of process parameters in extruding scaffold design using synthetic biomaterials
publisher	ModTech Publishing House
publishDate	2019
url	http://irep.iium.edu.my/77162/ http://irep.iium.edu.my/77162/1/05-%20Mohd%20Khairol%20Anuar%20Mohd%20Ariffin%20%282%29.pdf http://irep.iium.edu.my/77162/7/77162_The%20effect%20of%20process%20parameters%20in%20extruding%20scaffold%20design%20using%20synthetic%20biomaterials_Scopus.pdf
first_indexed	2023-09-18T21:48:53Z
last_indexed	2023-09-18T21:48:53Z
_version_	1777413634791571456

The effect of process parameters in extruding scaffold design using synthetic biomaterials

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