A novel antibacterial compound from an untapped plant: Stereospermum fimbriatum

Background: Stereospermum fimbriatum or locally known as “Chicha” is traditionally used for itchy skin, earache, stomachache and postpartum treatments. Objective: This study was designed to evaluate the antimicrobial potential of S. fimbriatum’s stem bark against 11 pathogens and isolate its bioacti...

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Main Authors:	Sarker, Md. Zaidul Islam, Awang, Anis Fadhlina Izyani, Ahmed, Qamar Uddin, Md. Jaffri, Juliana
Format:	Conference or Workshop Item
Language:	English English
Published:	2019
Subjects:	RS192 Materia Medica-Pharmaceutical Technology
Online Access:	http://irep.iium.edu.my/76986/ http://irep.iium.edu.my/76986/1/Abstract.pdf http://irep.iium.edu.my/76986/7/ID-76986-Oral%20slide.pdf

id	iium-76986
recordtype	eprints
spelling	iium-769862019-12-18T01:41:27Z http://irep.iium.edu.my/76986/ A novel antibacterial compound from an untapped plant: Stereospermum fimbriatum Sarker, Md. Zaidul Islam Awang, Anis Fadhlina Izyani Ahmed, Qamar Uddin Md. Jaffri, Juliana RS192 Materia Medica-Pharmaceutical Technology Background: Stereospermum fimbriatum or locally known as “Chicha” is traditionally used for itchy skin, earache, stomachache and postpartum treatments. Objective: This study was designed to evaluate the antimicrobial potential of S. fimbriatum’s stem bark against 11 pathogens and isolate its bioactive compound. Material and methods: Successive soxhlet extraction was conducted using n-hexane, dichloromethane (DCM) and methanol. Disc diffusion, minimum inhibitory and bactericidal concentration (MIC & MBC) assays were done to examine the antimicrobial activity. Bioassay-guided isolation was conducted on S. fimbriatum’s extract. Results: The DCM extract of stem bark (DS) was the most potent extract followed by n-hexane extract of the stem bark (NS). A novel compound was isolated and coded as C1 which demonstrated potent antibacterial effects with the MIC values as low as 3.13 μg/mL to 6.25 μg/mL, against S. epidermidis, MRSA and S. aureus. Conclusion: S. fimbriatum could be a potential source of antimicrobial agents for the treatment of skin infections, specifically, MRSA. 2019-11-30 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/76986/1/Abstract.pdf application/pdf en http://irep.iium.edu.my/76986/7/ID-76986-Oral%20slide.pdf Sarker, Md. Zaidul Islam and Awang, Anis Fadhlina Izyani and Ahmed, Qamar Uddin and Md. Jaffri, Juliana (2019) A novel antibacterial compound from an untapped plant: Stereospermum fimbriatum. In: AIMST International Pharmacy Conference (AIPC) 2019: Challenges and Opportunities in Pharmaceutical Sciences, Technology and Practice, 30 November - 1 December 2019, Faculty of Pharmacy, AIMST University, Semeling, Kedah. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RS192 Materia Medica-Pharmaceutical Technology
spellingShingle	RS192 Materia Medica-Pharmaceutical Technology Sarker, Md. Zaidul Islam Awang, Anis Fadhlina Izyani Ahmed, Qamar Uddin Md. Jaffri, Juliana A novel antibacterial compound from an untapped plant: Stereospermum fimbriatum
description	Background: Stereospermum fimbriatum or locally known as “Chicha” is traditionally used for itchy skin, earache, stomachache and postpartum treatments. Objective: This study was designed to evaluate the antimicrobial potential of S. fimbriatum’s stem bark against 11 pathogens and isolate its bioactive compound. Material and methods: Successive soxhlet extraction was conducted using n-hexane, dichloromethane (DCM) and methanol. Disc diffusion, minimum inhibitory and bactericidal concentration (MIC & MBC) assays were done to examine the antimicrobial activity. Bioassay-guided isolation was conducted on S. fimbriatum’s extract. Results: The DCM extract of stem bark (DS) was the most potent extract followed by n-hexane extract of the stem bark (NS). A novel compound was isolated and coded as C1 which demonstrated potent antibacterial effects with the MIC values as low as 3.13 μg/mL to 6.25 μg/mL, against S. epidermidis, MRSA and S. aureus. Conclusion: S. fimbriatum could be a potential source of antimicrobial agents for the treatment of skin infections, specifically, MRSA.
format	Conference or Workshop Item
author	Sarker, Md. Zaidul Islam Awang, Anis Fadhlina Izyani Ahmed, Qamar Uddin Md. Jaffri, Juliana
author_facet	Sarker, Md. Zaidul Islam Awang, Anis Fadhlina Izyani Ahmed, Qamar Uddin Md. Jaffri, Juliana
author_sort	Sarker, Md. Zaidul Islam
title	A novel antibacterial compound from an untapped plant: Stereospermum fimbriatum
title_short	A novel antibacterial compound from an untapped plant: Stereospermum fimbriatum
title_full	A novel antibacterial compound from an untapped plant: Stereospermum fimbriatum
title_fullStr	A novel antibacterial compound from an untapped plant: Stereospermum fimbriatum
title_full_unstemmed	A novel antibacterial compound from an untapped plant: Stereospermum fimbriatum
title_sort	novel antibacterial compound from an untapped plant: stereospermum fimbriatum
publishDate	2019
url	http://irep.iium.edu.my/76986/ http://irep.iium.edu.my/76986/1/Abstract.pdf http://irep.iium.edu.my/76986/7/ID-76986-Oral%20slide.pdf
first_indexed	2023-09-18T21:48:41Z
last_indexed	2023-09-18T21:48:41Z
_version_	1777413622530572288

A novel antibacterial compound from an untapped plant: Stereospermum fimbriatum

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